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- W4281650791 abstract "Cyclin-dependent kinase 1 (CDK1) is essential for cell division by regulating the G2/M phase and mitosis. CDK1 overexpression can also promote the development and progression of a variety of cancers. However, the significance of CDK1 in the formation, progression, and prognosis of human pan-cancer remains unclear. In the present study, we used The Cancer Genome Atlas database, Clinical Proteomic Tumor Analysis Consortium, Human Protein Atlas, Genotype-Tissue Expression, and other well-established databases to comprehensively examine CDK1 genetic alterations and gene/protein expression in various cancers and their relationships with the prognosis, immune reactivities, and clinical outcomes for 33 tumor types. Gene set enrichment analysis was also conducted to examine the potential mechanisms of CDK1 in tumorigenesis. The data showed that CDK1 mutation was frequently present in multiple tumors. CDK1 expression was significantly increased in various types of tumors as compared with normal tissues and was associated with poor overall and disease-free survival. In addition, CDK1 expression was significantly correlated with oncogenic genes, proteins, cellular components, myeloid-derived suppressor cell infiltration, ESTMATEScore, and signaling pathways associated with tumor development and progression and tumor microenvironments. These data indicate that CDK1 could serve as a promising biomarker for predicting tumor prognosis and a potential target for cancer treatment." @default.
- W4281650791 created "2022-06-13" @default.
- W4281650791 creator A5031058383 @default.
- W4281650791 creator A5053261559 @default.
- W4281650791 creator A5081428042 @default.
- W4281650791 date "2022-05-27" @default.
- W4281650791 modified "2023-10-18" @default.
- W4281650791 title "An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)" @default.
- W4281650791 cites W1966107523 @default.
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- W4281650791 cites W2004150448 @default.
- W4281650791 cites W2014946189 @default.
- W4281650791 cites W2021536610 @default.
- W4281650791 cites W2035618305 @default.
- W4281650791 cites W2046024621 @default.
- W4281650791 cites W2055222724 @default.
- W4281650791 cites W2067786443 @default.
- W4281650791 cites W2079019214 @default.
- W4281650791 cites W2080918762 @default.
- W4281650791 cites W2085961976 @default.
- W4281650791 cites W2089353165 @default.
- W4281650791 cites W2101930901 @default.
- W4281650791 cites W2114843025 @default.
- W4281650791 cites W2118629005 @default.
- W4281650791 cites W2130430382 @default.
- W4281650791 cites W2144776283 @default.
- W4281650791 cites W2158485828 @default.
- W4281650791 cites W2159707944 @default.
- W4281650791 cites W2166466732 @default.
- W4281650791 cites W2169143409 @default.
- W4281650791 cites W2177646046 @default.
- W4281650791 cites W2254274444 @default.
- W4281650791 cites W2523929848 @default.
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- W4281650791 cites W2792787855 @default.
- W4281650791 cites W2795989238 @default.
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- W4281650791 cites W2886911223 @default.
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- W4281650791 cites W2906684347 @default.
- W4281650791 cites W2912438236 @default.
- W4281650791 cites W2922400209 @default.
- W4281650791 cites W2942592603 @default.
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- W4281650791 cites W2996050529 @default.
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- W4281650791 cites W3133546985 @default.
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- W4281650791 doi "https://doi.org/10.3390/cancers14112658" @default.
- W4281650791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35681641" @default.
- W4281650791 hasPublicationYear "2022" @default.
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