FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281656534> ?p ?o ?g. }

• W4281656534 abstract "Abstract Anti-tumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial location of CD8 + T cells, within the tumor. Our earlier work demonstrated immunosuppressive effects of NOS2/ COX2 tumor expression. Here, we show that NOS2/COX2 levels influence the polarization and spatial location of lymphoid cells including CD8 + T cells. Importantly, elevated tumor NOS2/COX2 correlated with exclusion of CD8 + T cells from the tumor epithelium. In contrast, tumors expressing low NOS2/COX2 had increased CD8 + T cell penetration into the tumor epithelium. Consistent with a causative relationship between these observations, pharmacological inhibition of COX2 with indomethacin dramatically reduced tumor growth of the 4T1 model of TNBC in both WT and Nos2 -/- mice. This regimen led to complete tumor regression in ∼20% of tumor-bearing Nos2 -/- mice, and these animals were resistant to tumor rechallenge. Th1 cytokines were elevated in the blood of treated mice and intratumoral CD4 + and CD8 + T cells were higher in mice that received indomethacin when compared to control untreated mice. Multiplex immunofluorescence imaging confirmed our phenotyping results and demonstrated that targeted Nos2/Cox2 blockade improved CD8 + T cell penetration into the 4T1 tumor core. These findings are consistent with our observations in low NOS2/COX2 expressing breast tumors` proving that COX2 activity is responsible for limiting the spatial distribution of effector T cells in TNBC. Together these results suggest that clinically available NSAID’s may provide a cost-effective, novel immunotherapeutic approach for treatment of aggressive tumors including triple negative breast cancer." @default.
• W4281656534 created "2022-06-13" @default.
• W4281656534 creator A5002365439 @default.
• W4281656534 creator A5011055578 @default.
• W4281656534 creator A5013163732 @default.
• W4281656534 creator A5014732423 @default.
• W4281656534 creator A5015077092 @default.
• W4281656534 creator A5017672961 @default.
• W4281656534 creator A5027170042 @default.
• W4281656534 creator A5034056143 @default.
• W4281656534 creator A5037323622 @default.
• W4281656534 creator A5044559156 @default.
• W4281656534 creator A5044929543 @default.
• W4281656534 creator A5050561177 @default.
• W4281656534 creator A5052710405 @default.
• W4281656534 creator A5053591052 @default.
• W4281656534 creator A5056213840 @default.
• W4281656534 creator A5057465231 @default.
• W4281656534 creator A5058744784 @default.
• W4281656534 creator A5058844905 @default.
• W4281656534 creator A5067560793 @default.
• W4281656534 creator A5071454234 @default.
• W4281656534 creator A5077721978 @default.
• W4281656534 creator A5078106346 @default.
• W4281656534 creator A5081193554 @default.
• W4281656534 creator A5083934494 @default.
• W4281656534 creator A5090223620 @default.
• W4281656534 creator A5090468019 @default.
• W4281656534 date "2022-06-04" @default.
• W4281656534 modified "2023-10-02" @default.
• W4281656534 title "NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8⁺T Cell Spatial Orientation and Density" @default.
• W4281656534 cites W1530421518 @default.
• W4281656534 cites W1576287037 @default.
• W4281656534 cites W1964480573 @default.
• W4281656534 cites W1964909390 @default.
• W4281656534 cites W1992920273 @default.
• W4281656534 cites W2004552325 @default.
• W4281656534 cites W2031830523 @default.
• W4281656534 cites W2051348486 @default.
• W4281656534 cites W2069706769 @default.
• W4281656534 cites W2071119950 @default.
• W4281656534 cites W2101743784 @default.
• W4281656534 cites W2128149258 @default.
• W4281656534 cites W2141240574 @default.
• W4281656534 cites W2141865234 @default.
• W4281656534 cites W2142530756 @default.
• W4281656534 cites W2164810943 @default.
• W4281656534 cites W2168472227 @default.
• W4281656534 cites W2173069051 @default.
• W4281656534 cites W2234923158 @default.
• W4281656534 cites W2323415421 @default.
• W4281656534 cites W2344051158 @default.
• W4281656534 cites W2580657336 @default.
• W4281656534 cites W2583366335 @default.
• W4281656534 cites W2762285338 @default.
• W4281656534 cites W2767056523 @default.
• W4281656534 cites W2769545617 @default.
• W4281656534 cites W2781749016 @default.
• W4281656534 cites W2785396374 @default.
• W4281656534 cites W2803157002 @default.
• W4281656534 cites W2914282788 @default.
• W4281656534 cites W2928674156 @default.
• W4281656534 cites W2936541063 @default.
• W4281656534 cites W2949633340 @default.
• W4281656534 cites W2972545480 @default.
• W4281656534 cites W2980005092 @default.
• W4281656534 cites W2987914285 @default.
• W4281656534 cites W3001895421 @default.
• W4281656534 cites W3005410912 @default.
• W4281656534 cites W3126518591 @default.
• W4281656534 cites W3154548649 @default.
• W4281656534 cites W3207912452 @default.
• W4281656534 cites W4200007466 @default.
• W4281656534 doi "https://doi.org/10.1101/2022.06.03.494733" @default.
• W4281656534 hasPublicationYear "2022" @default.
• W4281656534 type Work @default.
• W4281656534 citedByCount "0" @default.
• W4281656534 crossrefType "posted-content" @default.
• W4281656534 hasAuthorship W4281656534A5002365439 @default.
• W4281656534 hasAuthorship W4281656534A5011055578 @default.
• W4281656534 hasAuthorship W4281656534A5013163732 @default.
• W4281656534 hasAuthorship W4281656534A5014732423 @default.
• W4281656534 hasAuthorship W4281656534A5015077092 @default.
• W4281656534 hasAuthorship W4281656534A5017672961 @default.
• W4281656534 hasAuthorship W4281656534A5027170042 @default.
• W4281656534 hasAuthorship W4281656534A5034056143 @default.
• W4281656534 hasAuthorship W4281656534A5037323622 @default.
• W4281656534 hasAuthorship W4281656534A5044559156 @default.
• W4281656534 hasAuthorship W4281656534A5044929543 @default.
• W4281656534 hasAuthorship W4281656534A5050561177 @default.
• W4281656534 hasAuthorship W4281656534A5052710405 @default.
• W4281656534 hasAuthorship W4281656534A5053591052 @default.
• W4281656534 hasAuthorship W4281656534A5056213840 @default.
• W4281656534 hasAuthorship W4281656534A5057465231 @default.
• W4281656534 hasAuthorship W4281656534A5058744784 @default.
• W4281656534 hasAuthorship W4281656534A5058844905 @default.
• W4281656534 hasAuthorship W4281656534A5067560793 @default.
• W4281656534 hasAuthorship W4281656534A5071454234 @default.
• W4281656534 hasAuthorship W4281656534A5077721978 @default.
• W4281656534 hasAuthorship W4281656534A5078106346 @default.

• next