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- W4281657514 abstract "An alternative model that reliably predicts human-specific toxicity is necessary because the translatability of effects on animal models for human disease is limited to context. Previously, we developed a method that accurately predicts developmental toxicity based on the gene networks of undifferentiated human embryonic stem (ES) cells. Here, we advanced this method to predict adult toxicities of 24 chemicals in six categories (neurotoxins, cardiotoxins, hepatotoxins, two types of nephrotoxins, and non-genotoxic carcinogens) and achieved high predictability (AUC = 0.90–1.00) in all categories. Moreover, we screened for an induced pluripotent stem (iPS) cell line to predict the toxicities based on the gene networks of iPS cells using transfer learning of the gene networks of ES cells, and predicted toxicities in four categories (neurotoxins, hepatotoxins, glomerular nephrotoxins, and non-genotoxic carcinogens) with high performance (AUC = 0.82–0.99). This method holds promise for tailor-made safety evaluations using personalized iPS cells." @default.
- W4281657514 created "2022-06-13" @default.
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- W4281657514 date "2022-07-01" @default.
- W4281657514 modified "2023-10-18" @default.
- W4281657514 title "StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells" @default.
- W4281657514 cites W101039434 @default.
- W4281657514 cites W1821797507 @default.
- W4281657514 cites W1975819262 @default.
- W4281657514 cites W1979583522 @default.
- W4281657514 cites W1985800918 @default.
- W4281657514 cites W1986813124 @default.
- W4281657514 cites W1988139353 @default.
- W4281657514 cites W1995262155 @default.
- W4281657514 cites W1996189501 @default.
- W4281657514 cites W2013188129 @default.
- W4281657514 cites W2025574029 @default.
- W4281657514 cites W2028134495 @default.
- W4281657514 cites W2035282461 @default.
- W4281657514 cites W2035603380 @default.
- W4281657514 cites W2037247915 @default.
- W4281657514 cites W2043703220 @default.
- W4281657514 cites W2045700441 @default.
- W4281657514 cites W2048687317 @default.
- W4281657514 cites W2049448933 @default.
- W4281657514 cites W2051598816 @default.
- W4281657514 cites W2051624959 @default.
- W4281657514 cites W2052418175 @default.
- W4281657514 cites W2053708844 @default.
- W4281657514 cites W2060421432 @default.
- W4281657514 cites W2070202276 @default.
- W4281657514 cites W2077375481 @default.
- W4281657514 cites W2082427958 @default.
- W4281657514 cites W2090133854 @default.
- W4281657514 cites W2097383958 @default.
- W4281657514 cites W2098288169 @default.
- W4281657514 cites W2098844173 @default.
- W4281657514 cites W2103856481 @default.
- W4281657514 cites W2109628662 @default.
- W4281657514 cites W2109823050 @default.
- W4281657514 cites W2110566790 @default.
- W4281657514 cites W2112326873 @default.
- W4281657514 cites W2114104545 @default.
- W4281657514 cites W2114889530 @default.
- W4281657514 cites W2116847459 @default.
- W4281657514 cites W2123308898 @default.
- W4281657514 cites W2132119775 @default.
- W4281657514 cites W2134430464 @default.
- W4281657514 cites W2137855409 @default.
- W4281657514 cites W2138092501 @default.
- W4281657514 cites W2146512944 @default.
- W4281657514 cites W2156801000 @default.
- W4281657514 cites W2157815908 @default.
- W4281657514 cites W2166334080 @default.
- W4281657514 cites W2167930585 @default.
- W4281657514 cites W2200202420 @default.
- W4281657514 cites W2279950965 @default.
- W4281657514 cites W2398989175 @default.
- W4281657514 cites W2400926507 @default.
- W4281657514 cites W2401429675 @default.
- W4281657514 cites W2401817087 @default.
- W4281657514 cites W2402318050 @default.
- W4281657514 cites W2407727408 @default.
- W4281657514 cites W2410638096 @default.
- W4281657514 cites W2412233936 @default.
- W4281657514 cites W2462099493 @default.
- W4281657514 cites W2538173180 @default.
- W4281657514 cites W2552806728 @default.
- W4281657514 cites W2626957623 @default.
- W4281657514 cites W2726905986 @default.
- W4281657514 cites W2809523596 @default.
- W4281657514 cites W2811329289 @default.
- W4281657514 cites W2925970523 @default.
- W4281657514 cites W2944454606 @default.
- W4281657514 cites W2973820246 @default.
- W4281657514 cites W3006339909 @default.
- W4281657514 cites W3015092648 @default.
- W4281657514 cites W3021575798 @default.
- W4281657514 cites W3084374992 @default.
- W4281657514 cites W3085738785 @default.
- W4281657514 cites W3121495924 @default.
- W4281657514 cites W3129933668 @default.
- W4281657514 cites W4205563404 @default.
- W4281657514 cites W4239510810 @default.
- W4281657514 cites W4252816724 @default.