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• W4281660132 endingPage "802" @default.
• W4281660132 startingPage "802" @default.
• W4281660132 abstract "The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell proliferation and growth in response to insulin, amino acids, energy levels, and oxygen. mTOR can coordinate upstream signals with downstream effectors, including transcriptional and translational apparatuses to regulate fundamental cellular processes such as energy utilization, protein synthesis, autophagy, cell growth, and proliferation. Of the above, protein synthesis is highly energy-consuming; thus, mRNA translation is under the tight and immediate control of mTOR signaling. The translational regulation driven by mTOR signaling mainly relies on eukaryotic translation initiation factor 4E (eIF4E)-binding protein (4E-BP), ribosomal protein S6 kinase (S6K), and its downstream players, which are significant in rapid cellular response to environmental change. mTOR signaling not only controls the general mRNA translation, but preferential mRNA translation as well. This means that mTOR signaling shows the stronger selectivity to particular target mRNAs. Some evidence has supported the contribution of 4E-BP and La-related proteins 1 (LARP1) to such translational regulation. In this review, we summarize the mTOR pathway and mainly focus on mTOR-mediated mRNA translational regulation. We introduce the major components of mTOR signaling and their functions in translational control in a general or particular manner, and describe how the specificity of regulation is coordinated. Furthermore, we summarize recent research progress and propose additional ideas for reference. Because the mTOR pathway is on the center of cell growth and metabolism, comprehensively understanding this pathway will contribute to the therapy of related diseases, including cancers, type 2 diabetes, obesity, and neurodegeneration." @default.
• W4281660132 created "2022-06-13" @default.
• W4281660132 creator A5006232552 @default.
• W4281660132 creator A5017770794 @default.
• W4281660132 creator A5030979574 @default.
• W4281660132 creator A5085371500 @default.
• W4281660132 date "2022-06-08" @default.
• W4281660132 modified "2023-09-30" @default.
• W4281660132 title "The Translational Regulation in mTOR Pathway" @default.
• W4281660132 cites W1523304533 @default.
• W4281660132 cites W1523693806 @default.
• W4281660132 cites W1589421810 @default.
• W4281660132 cites W169736967 @default.
• W4281660132 cites W1859240609 @default.
• W4281660132 cites W1933156045 @default.
• W4281660132 cites W1941339056 @default.
• W4281660132 cites W1963688091 @default.
• W4281660132 cites W1963807140 @default.
• W4281660132 cites W1965980060 @default.
• W4281660132 cites W1966714311 @default.
• W4281660132 cites W1970111367 @default.
• W4281660132 cites W1970637701 @default.
• W4281660132 cites W1980396381 @default.
• W4281660132 cites W1981001162 @default.
• W4281660132 cites W1983612365 @default.
• W4281660132 cites W1986301677 @default.
• W4281660132 cites W1992170852 @default.
• W4281660132 cites W1992631886 @default.
• W4281660132 cites W1993879781 @default.
• W4281660132 cites W1999999605 @default.
• W4281660132 cites W2002226709 @default.
• W4281660132 cites W2004451132 @default.
• W4281660132 cites W2004526658 @default.
• W4281660132 cites W2004688803 @default.
• W4281660132 cites W2005066107 @default.
• W4281660132 cites W2006980279 @default.
• W4281660132 cites W2007086793 @default.
• W4281660132 cites W2008102952 @default.
• W4281660132 cites W2008825756 @default.
• W4281660132 cites W2012142261 @default.
• W4281660132 cites W2013385077 @default.
• W4281660132 cites W2018274938 @default.
• W4281660132 cites W2020401706 @default.
• W4281660132 cites W2034752843 @default.
• W4281660132 cites W2035521247 @default.
• W4281660132 cites W2038874082 @default.
• W4281660132 cites W2048646626 @default.
• W4281660132 cites W2050696207 @default.
• W4281660132 cites W2050988292 @default.
• W4281660132 cites W2056772716 @default.
• W4281660132 cites W2057106513 @default.
• W4281660132 cites W2060905299 @default.
• W4281660132 cites W2063013559 @default.
• W4281660132 cites W2065232971 @default.
• W4281660132 cites W2065887259 @default.
• W4281660132 cites W2066659565 @default.
• W4281660132 cites W2078184757 @default.
• W4281660132 cites W2082564115 @default.
• W4281660132 cites W2086239621 @default.
• W4281660132 cites W2087136249 @default.
• W4281660132 cites W2089668045 @default.
• W4281660132 cites W2089738145 @default.
• W4281660132 cites W2093431913 @default.
• W4281660132 cites W2094853437 @default.
• W4281660132 cites W2098912234 @default.
• W4281660132 cites W2101083009 @default.
• W4281660132 cites W2114859236 @default.
• W4281660132 cites W2117028091 @default.
• W4281660132 cites W2120356140 @default.
• W4281660132 cites W2125666085 @default.
• W4281660132 cites W2127063807 @default.
• W4281660132 cites W2136272779 @default.
• W4281660132 cites W2136676465 @default.
• W4281660132 cites W2137238711 @default.
• W4281660132 cites W2138044466 @default.
• W4281660132 cites W2139856846 @default.
• W4281660132 cites W2139948451 @default.
• W4281660132 cites W2145323463 @default.
• W4281660132 cites W2150351516 @default.
• W4281660132 cites W2152289580 @default.
• W4281660132 cites W2153188271 @default.
• W4281660132 cites W2153607816 @default.
• W4281660132 cites W2158612356 @default.
• W4281660132 cites W2164462432 @default.
• W4281660132 cites W2168180694 @default.
• W4281660132 cites W2169784061 @default.
• W4281660132 cites W2175514210 @default.
• W4281660132 cites W2207318443 @default.
• W4281660132 cites W2231236206 @default.
• W4281660132 cites W2240434829 @default.
• W4281660132 cites W2297165574 @default.
• W4281660132 cites W2312282875 @default.
• W4281660132 cites W2316850457 @default.
• W4281660132 cites W2322618593 @default.
• W4281660132 cites W2407198816 @default.
• W4281660132 cites W2415974789 @default.
• W4281660132 cites W2485377503 @default.
• W4281660132 cites W2517175971 @default.

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