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• W4281664851 endingPage "137333" @default.
• W4281664851 startingPage "137333" @default.
• W4281664851 abstract "• A nanoplatform integrated by fluorescent metal–organic frameworks and nanozyme. • Obtained nanoplatform with excellent fluorescence imaging and anti-tumor ability. • Real-time monitoring of intracellular singlet oxygen during photodynamic therapy. • Enhanced photodynamic therapy by alleviating the tumor hypoxia. Singlet oxygen ( 1 O 2 ) is one of the primary reactive oxygen species (ROS) during photodynamic therapy (PDT), so monitoring the generation of 1 O 2 is of tremendous help for evaluating the PDT efficacy and further adjusting the treatment regimens. However, of particular note, the PDT efficacy is restricted by the intrinsic hypoxic problem of tumor microenvironment. Herein, anthracene-based fluorescent MOFs decorated by platinum (Pt) nanozymes (TCPP@DPA-MOF-Pt, TDMP) as a multifunctional therapeutic and sensing nanoplatform was fabricated to achieve the integration of PDT effect, O 2 self-sufficiency, and intracellular 1 O 2 self-monitoring. The Pt-decorated fluorescent nanoplatform displayed sustained H 2 O 2 catalytic ability and superior 1 O 2 sensing performance in solution. At the cellular level, it exhibited satisfactory biocompatibility and enabled be efficiently internalized into the cells on account of an appropriate particle size (∼100 nm). More importantly, in the hypoxic environment, the surface-decorated Pt NPs served as catalase-mimicking nanozymes and were able to effectively achieve O 2 self-sufficiency, thereby greatly improving the efficacy of PDT. Simultaneously, the anthracene ligand DPA could real-time monitor intracellular 1 O 2 during PDT through self-fluorescence quenching, thus realizing a self-feedback function for PDT efficacy tracking. This study offers an innovative strategy to integrate fluorescent MOFs and nanozymes into a nanoplatform for achieving enhanced PDT efficacy and intracellular 1 O 2 self-monitoring during PDT." @default.
• W4281664851 created "2022-06-13" @default.
• W4281664851 creator A5023370965 @default.
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• W4281664851 date "2022-10-01" @default.
• W4281664851 modified "2023-10-12" @default.
• W4281664851 title "Anthracene-based fluorescent MOFs decorated by platinum nanozymes as a multifunctional nanoplatform for enhanced photodynamic therapy and self-monitoring of real-time singlet oxygen" @default.
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• W4281664851 doi "https://doi.org/10.1016/j.cej.2022.137333" @default.
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