Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281666183> ?p ?o ?g. }
- W4281666183 endingPage "146644" @default.
- W4281666183 startingPage "146644" @default.
- W4281666183 abstract "Bacillus velezensis has recently received increasing attention as a biological fungicide and a potential probiotic agent because of its broad spectrum of antibacterial and antifungal activities. Here, we evaluated the beneficial traits of a newly isolated B. velezensis strain LOH112 using comprehensive bioinformatics and comparative genomic analyses and in vitro experimental approaches. Whole genome sequencing and assembly results showed that the genome of LOH112 consists of a circular chromosome and a circular plasmid, which encodes proteins involved in important biological processes such as sporulation, quorum sensing, and antibiotic synthesis. LOH112 contains 13 secondary metabolism gene clusters responsible for the production of antimicrobial compounds. In vitro experiments showed that LOH112 effectively inhibits several fungi and Gram-positive pathogenic bacteria, hydrolyzes protein and cellulose, and is capable of forming strong adhesive biofilms. Furthermore, comparative genomics revealed that LOH112 contains 34 strain-specific orthologous gene clusters, including two caseinolytic protease P (clpP) genes responsible for proteomic homeostasis. Selective pressure analysis indicated that the transmembrane transporter and ATP-dependent alanine/valine adenylase genes were strongly positively selected, which may endow LOH112 with better biocontrol ability and potential probiotic properties. Collectively, these results not only provide insights into a deeper understanding of the genomic characterization of LOH112 but also imply the potential application of LOH112 as biocontrol and probiotic agents." @default.
- W4281666183 created "2022-06-13" @default.
- W4281666183 creator A5007920592 @default.
- W4281666183 creator A5047636176 @default.
- W4281666183 creator A5055755533 @default.
- W4281666183 creator A5062316797 @default.
- W4281666183 creator A5067887136 @default.
- W4281666183 creator A5072071140 @default.
- W4281666183 creator A5091638985 @default.
- W4281666183 date "2022-08-01" @default.
- W4281666183 modified "2023-09-23" @default.
- W4281666183 title "Comparative genomics analysis of Bacillus velezensis LOH112 isolated from a nonagenarian provides insights into its biocontrol and probiotic traits" @default.
- W4281666183 cites W1798218047 @default.
- W4281666183 cites W1800540606 @default.
- W4281666183 cites W1981473578 @default.
- W4281666183 cites W1982855075 @default.
- W4281666183 cites W1983475495 @default.
- W4281666183 cites W1983549218 @default.
- W4281666183 cites W1988172134 @default.
- W4281666183 cites W1988584796 @default.
- W4281666183 cites W1991619536 @default.
- W4281666183 cites W2004548026 @default.
- W4281666183 cites W2031353057 @default.
- W4281666183 cites W2048840381 @default.
- W4281666183 cites W2069511429 @default.
- W4281666183 cites W2079353889 @default.
- W4281666183 cites W2079513009 @default.
- W4281666183 cites W2083327670 @default.
- W4281666183 cites W2094201044 @default.
- W4281666183 cites W2105999876 @default.
- W4281666183 cites W2108230379 @default.
- W4281666183 cites W2108787198 @default.
- W4281666183 cites W2118095913 @default.
- W4281666183 cites W2120902911 @default.
- W4281666183 cites W2124513219 @default.
- W4281666183 cites W2127391962 @default.
- W4281666183 cites W2129211910 @default.
- W4281666183 cites W2129978006 @default.
- W4281666183 cites W2130124027 @default.
- W4281666183 cites W2130263042 @default.
- W4281666183 cites W2133371096 @default.
- W4281666183 cites W2143485490 @default.
- W4281666183 cites W2149429041 @default.
- W4281666183 cites W2149665569 @default.
- W4281666183 cites W2151529778 @default.
- W4281666183 cites W2151831732 @default.
- W4281666183 cites W2158804744 @default.
- W4281666183 cites W2160440240 @default.
- W4281666183 cites W2163941254 @default.
- W4281666183 cites W2164154943 @default.
- W4281666183 cites W2178894447 @default.
- W4281666183 cites W2237264682 @default.
- W4281666183 cites W2306404099 @default.
- W4281666183 cites W2346680365 @default.
- W4281666183 cites W2417593230 @default.
- W4281666183 cites W2418895622 @default.
- W4281666183 cites W2507811370 @default.
- W4281666183 cites W2569153326 @default.
- W4281666183 cites W2589453726 @default.
- W4281666183 cites W2596914435 @default.
- W4281666183 cites W2614368068 @default.
- W4281666183 cites W2783129095 @default.
- W4281666183 cites W2784332818 @default.
- W4281666183 cites W2790367768 @default.
- W4281666183 cites W2791785912 @default.
- W4281666183 cites W2799524357 @default.
- W4281666183 cites W2803535702 @default.
- W4281666183 cites W2886333926 @default.
- W4281666183 cites W2903704142 @default.
- W4281666183 cites W2921298371 @default.
- W4281666183 cites W2924766970 @default.
- W4281666183 cites W2942829220 @default.
- W4281666183 cites W2950354111 @default.
- W4281666183 cites W2969955212 @default.
- W4281666183 cites W2983252652 @default.
- W4281666183 cites W2996907738 @default.
- W4281666183 cites W3007240613 @default.
- W4281666183 cites W3034477559 @default.
- W4281666183 cites W3036319615 @default.
- W4281666183 cites W3039887200 @default.
- W4281666183 cites W3039899542 @default.
- W4281666183 cites W3042057078 @default.
- W4281666183 cites W3048202740 @default.
- W4281666183 cites W3087980391 @default.
- W4281666183 cites W3092438348 @default.
- W4281666183 cites W3093785157 @default.
- W4281666183 cites W3132637251 @default.
- W4281666183 cites W3138552287 @default.
- W4281666183 cites W3156458251 @default.
- W4281666183 cites W3160086298 @default.
- W4281666183 cites W3175523976 @default.
- W4281666183 cites W3181705716 @default.
- W4281666183 cites W4239954008 @default.
- W4281666183 doi "https://doi.org/10.1016/j.gene.2022.146644" @default.
- W4281666183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35680027" @default.
- W4281666183 hasPublicationYear "2022" @default.
- W4281666183 type Work @default.
- W4281666183 citedByCount "3" @default.