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- W4281667327 abstract "Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by repetitive and stereotyped behaviors as well as difficulties with social interaction and communication. According to reports for prevalence rates of ASD, approximately 1~2% of children worldwide have been diagnosed with ASD. Although there are a couple of FDA (Food and Drug Administration)-approved drugs for ASD treatment such as aripiprazole and risperidone, they are efficient for alleviating aggression, hyperactivity, and self-injury but not the core symptoms. Serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter plays a crucial role in the early neurodevelopmental stage. In particular, 5-HT has been known to regulate a variety of neurobiological processes including neurite outgrowth, dendritic spine morphology, shaping neuronal circuits, synaptic transmission, and synaptic plasticity. Given the roles of serotonergic systems, the 5-HT receptors (5-HTRs) become emerging as potential therapeutic targets in the ASD. In this review, we will focus on the recent development of small molecule modulators of 5-HTRs as therapeutic targets for the ASD treatment." @default.
- W4281667327 created "2022-06-13" @default.
- W4281667327 creator A5025724304 @default.
- W4281667327 creator A5054674828 @default.
- W4281667327 creator A5088817362 @default.
- W4281667327 date "2022-06-10" @default.
- W4281667327 modified "2023-10-14" @default.
- W4281667327 title "Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment" @default.
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