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• W4281667616 endingPage "1934578X2211020" @default.
• W4281667616 startingPage "1934578X2211020" @default.
• W4281667616 abstract "Liver cancer, otherwise known as hepatocellular carcinoma, is a chronic disease condition with an excessive deposition and growth of malignant cells in the body. The high incidence and prevalence rates of liver cancer continue to be problems, as well as its poor prognosis and therapeutic limitations involving severe drug adverse reactions linked to the use of synthetic chemotherapeutic compounds. Continuous experimental studies, as well as utilization of pure herbal-based compounds, are essential towards finding more potent cures for liver cancer. Natural bioactive compounds, particularly alkaloids (eg, berberine), have been shown to be highly beneficial in the treatment of various diseases. Berberine (BBR), an isoquinoline alkaloid, is obtained from stem, bark, roots, rhizomes, and leaves of several medicinal plants, including Berberis species. It is commonly synthesized from the benzyltetrahydroisoquinoline system with the incorporation of an additional carbon atom as a bridge. The multiple attributes of BBR involving effective inhibitory and cytotoxic actions against the proliferation of cancer cells have been demonstrated. The use of BBR in experimental studies (in vivo and in vitro) for over a decade for liver cancer treatment has proven to be highly effective, safe, and potent. Until now, the poor solubility of BBR remains one of the contributing factors leading to its minimal clinical bioavailability. Therefore, BBR could serve as a prospective drug candidate in the future towards drug formulation for liver cancer treatment. The relevant information regarding this review was obtained electronically through the use of databases such as PubMed, Google Scholar, Springer, Hindawi, Embase, Web of Science, and China National Knowledge Infrastructure. All the aforementioned databases were searched from 1981 to 2020. This literature represents an update of previous review papers discussing the various positive pharmacological and mechanistic effects (oxidative stress regulation, inflammation reduction, apoptosis activation, overcoming drug resistance, and metastasis inhibition) of BBR for liver cancer treatment, which would be of great significance to drug development and clinical research." @default.
• W4281667616 created "2022-06-13" @default.
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• W4281667616 date "2022-05-01" @default.
• W4281667616 modified "2023-09-26" @default.
• W4281667616 title "Effects of Berberine on Liver Cancer" @default.
• W4281667616 cites W1569168257 @default.
• W4281667616 cites W1684275107 @default.
• W4281667616 cites W1774024527 @default.
• W4281667616 cites W1896464242 @default.
• W4281667616 cites W1961881993 @default.
• W4281667616 cites W1965308849 @default.
• W4281667616 cites W1976281740 @default.
• W4281667616 cites W1981389898 @default.
• W4281667616 cites W1985618656 @default.
• W4281667616 cites W1990642243 @default.
• W4281667616 cites W1998817605 @default.
• W4281667616 cites W2000036013 @default.
• W4281667616 cites W2000409395 @default.
• W4281667616 cites W2008313230 @default.
• W4281667616 cites W2014271062 @default.
• W4281667616 cites W2019292217 @default.
• W4281667616 cites W2026184385 @default.
• W4281667616 cites W2030882694 @default.
• W4281667616 cites W2035615201 @default.
• W4281667616 cites W2043254322 @default.
• W4281667616 cites W2044290342 @default.
• W4281667616 cites W2047701750 @default.
• W4281667616 cites W2050339595 @default.
• W4281667616 cites W2052193587 @default.
• W4281667616 cites W2055585726 @default.
• W4281667616 cites W2056422699 @default.
• W4281667616 cites W2058862045 @default.
• W4281667616 cites W2059617569 @default.
• W4281667616 cites W2060058159 @default.
• W4281667616 cites W2062110065 @default.
• W4281667616 cites W2063219381 @default.
• W4281667616 cites W2065662140 @default.
• W4281667616 cites W2072764839 @default.
• W4281667616 cites W2074310251 @default.
• W4281667616 cites W2074457869 @default.
• W4281667616 cites W2079931904 @default.
• W4281667616 cites W2086887892 @default.
• W4281667616 cites W2091973278 @default.
• W4281667616 cites W2096108416 @default.
• W4281667616 cites W2102880109 @default.
• W4281667616 cites W2106787323 @default.
• W4281667616 cites W2109653420 @default.
• W4281667616 cites W2126399705 @default.
• W4281667616 cites W2136987307 @default.
• W4281667616 cites W2140688545 @default.
• W4281667616 cites W2143877891 @default.
• W4281667616 cites W2147949348 @default.
• W4281667616 cites W2294798900 @default.
• W4281667616 cites W2299985447 @default.
• W4281667616 cites W2336974981 @default.
• W4281667616 cites W2340190976 @default.
• W4281667616 cites W2418778005 @default.
• W4281667616 cites W2465766276 @default.
• W4281667616 cites W2519209122 @default.
• W4281667616 cites W2525429999 @default.
• W4281667616 cites W2525906202 @default.
• W4281667616 cites W2560593836 @default.
• W4281667616 cites W2584048291 @default.
• W4281667616 cites W2593180135 @default.
• W4281667616 cites W2598450211 @default.
• W4281667616 cites W2604636580 @default.
• W4281667616 cites W2614857817 @default.
• W4281667616 cites W2617951505 @default.
• W4281667616 cites W2626811882 @default.
• W4281667616 cites W2751681739 @default.
• W4281667616 cites W2781133631 @default.
• W4281667616 cites W2803279238 @default.
• W4281667616 cites W2803975872 @default.
• W4281667616 cites W2810535074 @default.
• W4281667616 cites W2880371521 @default.
• W4281667616 cites W2884422482 @default.
• W4281667616 cites W2885844771 @default.
• W4281667616 cites W2887487816 @default.
• W4281667616 cites W2888404374 @default.
• W4281667616 cites W2898211364 @default.
• W4281667616 cites W2901670101 @default.
• W4281667616 cites W2903570689 @default.
• W4281667616 cites W2911188335 @default.
• W4281667616 cites W2916077054 @default.
• W4281667616 cites W2933577127 @default.
• W4281667616 cites W2946876971 @default.
• W4281667616 cites W2946917215 @default.

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