FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281669076> ?p ?o ?g. }

• W4281669076 endingPage "6392" @default.
• W4281669076 startingPage "6392" @default.
• W4281669076 abstract "DNA damage during early life stages may have a negative effect on embryo development, inducing mortality and malformations that have long-lasting effects during adult life. Therefore, in the current study, we analyzed the effect of DNA damage induced by genotoxicants (camptothecin (CPT) and olaparib) at different stages of embryo development. The survival, DNA fragmentation, transcriptome, and proteome of the endangered sturgeon Acipenser ruthenus were analyzed. Sturgeons are non-model fish species that can provide new insights into the DNA damage response and embryo development. The transcriptomic and proteomic patterns changed significantly after exposure to genotoxicants in a stage-dependent manner. The results of this study indicate a correlation between phenotype formation and changes in transcriptomic and proteomic profiles. CPT and olaparib downregulated oxidative phosphorylation and metabolic pathways, and upregulated pathways involved in nucleotide excision repair, base excision repair, and homologous recombination. We observed the upregulated expression of zona pellucida sperm-binding proteins in all treatment groups, as well as the upregulation of several glycolytic enzymes. The analysis of gene expression revealed several markers of DNA damage response and adaptive stress response, which could be applied in toxicological studies on fish embryos. This study is the first complex analysis of the DNA damage response in endangered sturgeons." @default.
• W4281669076 created "2022-06-13" @default.
• W4281669076 creator A5005295328 @default.
• W4281669076 creator A5017690299 @default.
• W4281669076 creator A5019327785 @default.
• W4281669076 creator A5029848256 @default.
• W4281669076 creator A5030448700 @default.
• W4281669076 creator A5038626702 @default.
• W4281669076 creator A5045754533 @default.
• W4281669076 creator A5051194123 @default.
• W4281669076 date "2022-06-07" @default.
• W4281669076 modified "2023-10-14" @default.
• W4281669076 title "Transcriptome and Proteome Analyses Reveal Stage-Specific DNA Damage Response in Embryos of Sturgeon (Acipenser ruthenus)" @default.
• W4281669076 cites W1572098237 @default.
• W4281669076 cites W1980370917 @default.
• W4281669076 cites W1985778896 @default.
• W4281669076 cites W1987617277 @default.
• W4281669076 cites W1999314545 @default.
• W4281669076 cites W2012099961 @default.
• W4281669076 cites W2039860296 @default.
• W4281669076 cites W2047004530 @default.
• W4281669076 cites W2051298041 @default.
• W4281669076 cites W2054280836 @default.
• W4281669076 cites W2112532025 @default.
• W4281669076 cites W2124799197 @default.
• W4281669076 cites W2129899548 @default.
• W4281669076 cites W2129914522 @default.
• W4281669076 cites W2130730147 @default.
• W4281669076 cites W2131271579 @default.
• W4281669076 cites W2141224543 @default.
• W4281669076 cites W2145335003 @default.
• W4281669076 cites W2147399165 @default.
• W4281669076 cites W2179438025 @default.
• W4281669076 cites W2496919955 @default.
• W4281669076 cites W2572090623 @default.
• W4281669076 cites W2590603178 @default.
• W4281669076 cites W2594694314 @default.
• W4281669076 cites W2754965820 @default.
• W4281669076 cites W2757972128 @default.
• W4281669076 cites W2794848794 @default.
• W4281669076 cites W2795743848 @default.
• W4281669076 cites W2801005106 @default.
• W4281669076 cites W2896229143 @default.
• W4281669076 cites W2941814721 @default.
• W4281669076 cites W2944545583 @default.
• W4281669076 cites W2950219609 @default.
• W4281669076 cites W2980038392 @default.
• W4281669076 cites W2995472912 @default.
• W4281669076 cites W3009356145 @default.
• W4281669076 cites W3013355236 @default.
• W4281669076 cites W3020923482 @default.
• W4281669076 cites W3032789554 @default.
• W4281669076 cites W3041141216 @default.
• W4281669076 cites W3044632739 @default.
• W4281669076 cites W3092161883 @default.
• W4281669076 cites W3094743759 @default.
• W4281669076 cites W3095820775 @default.
• W4281669076 cites W3103690492 @default.
• W4281669076 cites W3105178875 @default.
• W4281669076 cites W3111540887 @default.
• W4281669076 cites W3113530253 @default.
• W4281669076 cites W3116847201 @default.
• W4281669076 cites W3123123300 @default.
• W4281669076 cites W3133901658 @default.
• W4281669076 cites W3137295924 @default.
• W4281669076 cites W3186661044 @default.
• W4281669076 cites W4211051773 @default.
• W4281669076 cites W4236530034 @default.
• W4281669076 doi "https://doi.org/10.3390/ijms23126392" @default.
• W4281669076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35742841" @default.
• W4281669076 hasPublicationYear "2022" @default.
• W4281669076 type Work @default.
• W4281669076 citedByCount "2" @default.
• W4281669076 countsByYear W42816690762023 @default.
• W4281669076 crossrefType "journal-article" @default.
• W4281669076 hasAuthorship W4281669076A5005295328 @default.
• W4281669076 hasAuthorship W4281669076A5017690299 @default.
• W4281669076 hasAuthorship W4281669076A5019327785 @default.
• W4281669076 hasAuthorship W4281669076A5029848256 @default.
• W4281669076 hasAuthorship W4281669076A5030448700 @default.
• W4281669076 hasAuthorship W4281669076A5038626702 @default.
• W4281669076 hasAuthorship W4281669076A5045754533 @default.
• W4281669076 hasAuthorship W4281669076A5051194123 @default.
• W4281669076 hasBestOaLocation W42816690761 @default.
• W4281669076 hasConcept C104317684 @default.
• W4281669076 hasConcept C104397665 @default.
• W4281669076 hasConcept C134935766 @default.
• W4281669076 hasConcept C143425029 @default.
• W4281669076 hasConcept C150194340 @default.
• W4281669076 hasConcept C162317418 @default.
• W4281669076 hasConcept C182979987 @default.
• W4281669076 hasConcept C190283241 @default.
• W4281669076 hasConcept C2779962180 @default.
• W4281669076 hasConcept C31573885 @default.
• W4281669076 hasConcept C43759708 @default.
• W4281669076 hasConcept C54355233 @default.
• W4281669076 hasConcept C552990157 @default.
• W4281669076 hasConcept C82381507 @default.

• next