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- W4281670932 abstract "In chemical synapses undergoing high frequency stimulation, vesicle components can be retrieved from the plasma membrane via a clathrin-independent process called activity-dependent bulk endocytosis (ADBE). Alix (ALG-2-interacting protein X/PDCD6IP) is an adaptor protein binding to ESCRT and endophilin-A proteins which is required for clathrin-independent endocytosis in fibroblasts. Alix is expressed in neurons and concentrates at synapses during epileptic seizures. Here, we used cultured neurons to show that Alix is recruited to presynapses where it interacts with and concentrates endophilin-A during conditions triggering ADBE. Using Alix knockout (ko) neurons, we showed that this recruitment, which requires interaction with the calcium-binding protein ALG-2, is necessary for ADBE. We also found that presynaptic compartments of Alix ko hippocampi display subtle morphological defects compatible with flawed synaptic activity and plasticity detected electrophysiologically. Furthermore, mice lacking Alix in the forebrain undergo less seizures during kainate-induced status epilepticus and reduced propagation of the epileptiform activity. These results thus show that impairment of ADBE due to the lack of neuronal Alix leads to abnormal synaptic recovery during physiological or pathological repeated stimulations." @default.
- W4281670932 created "2022-06-13" @default.
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- W4281670932 date "2022-06-03" @default.
- W4281670932 modified "2023-10-06" @default.
- W4281670932 title "Alix is required for activity-dependent bulk endocytosis at brain synapses" @default.
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- W4281670932 cites W1967238741 @default.
- W4281670932 cites W1982745353 @default.
- W4281670932 cites W1987398739 @default.
- W4281670932 cites W1995775196 @default.
- W4281670932 cites W1999679029 @default.
- W4281670932 cites W2005718392 @default.
- W4281670932 cites W2006955217 @default.
- W4281670932 cites W2009023024 @default.
- W4281670932 cites W2010905290 @default.
- W4281670932 cites W2015690593 @default.
- W4281670932 cites W2019869168 @default.
- W4281670932 cites W2020665983 @default.
- W4281670932 cites W2028222629 @default.
- W4281670932 cites W2030054100 @default.
- W4281670932 cites W2033021180 @default.
- W4281670932 cites W2037947871 @default.
- W4281670932 cites W2042124706 @default.
- W4281670932 cites W2043242731 @default.
- W4281670932 cites W2053957762 @default.
- W4281670932 cites W2057675465 @default.
- W4281670932 cites W2058426397 @default.
- W4281670932 cites W2058568944 @default.
- W4281670932 cites W2058873141 @default.
- W4281670932 cites W2062829534 @default.
- W4281670932 cites W2063116040 @default.
- W4281670932 cites W2067013656 @default.
- W4281670932 cites W2071877471 @default.
- W4281670932 cites W2080058891 @default.
- W4281670932 cites W2080281567 @default.
- W4281670932 cites W2081070804 @default.
- W4281670932 cites W2084831913 @default.
- W4281670932 cites W2091484145 @default.
- W4281670932 cites W2100782247 @default.
- W4281670932 cites W2103946141 @default.
- W4281670932 cites W2106628227 @default.
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- W4281670932 cites W2119215402 @default.
- W4281670932 cites W2123788299 @default.
- W4281670932 cites W2125752525 @default.
- W4281670932 cites W2135461141 @default.
- W4281670932 cites W2135719485 @default.
- W4281670932 cites W2144107809 @default.
- W4281670932 cites W2147191089 @default.
- W4281670932 cites W2162423225 @default.
- W4281670932 cites W2167511682 @default.
- W4281670932 cites W2296069419 @default.
- W4281670932 cites W2412560414 @default.
- W4281670932 cites W2472225832 @default.
- W4281670932 cites W2509350040 @default.
- W4281670932 cites W2512606991 @default.
- W4281670932 cites W2557155892 @default.
- W4281670932 cites W2590662729 @default.
- W4281670932 cites W2601644732 @default.
- W4281670932 cites W2746656491 @default.
- W4281670932 cites W2767430428 @default.
- W4281670932 cites W2805496163 @default.
- W4281670932 cites W2806837850 @default.
- W4281670932 cites W2809799315 @default.
- W4281670932 cites W2895980273 @default.
- W4281670932 cites W2897255388 @default.
- W4281670932 cites W2973906384 @default.
- W4281670932 cites W2999624787 @default.
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- W4281670932 doi "https://doi.org/10.1371/journal.pbio.3001659" @default.
- W4281670932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35658004" @default.
- W4281670932 hasPublicationYear "2022" @default.
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