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- W4281673471 abstract "Autism spectrum disorder (ASD) is acknowledged as a highly heterogeneous, behaviorally defined neurodevelopmental disorder with multiple etiologies. In addition to its high heritability, we have come to recognize a role for maternal immune system dysregulation as a prominent risk factor for the development of ASD in the child. Examples of these risk factors include altered cytokine/chemokine activity and the presence of autoantibodies in mothers that are reactive to proteins in the developing brain. In addition to large clinical studies, the development of pre-clinical models enables the ability to evaluate the cellular and molecular underpinnings of immune-related pathology. For example, the novel animal models of maternal autoantibody-related (MAR) ASD described herein will serve as a preclinical platform for the future testing of targeted therapeutics for one 'type' of ASD. Identification of the cellular targets will advance precision medicine efforts toward tailored therapeutics and prevention. This minireview highlights emerging evidence for the role of maternal immune dysregulation as a potential biomarker, as well as a pathologically relevant mechanism for the development of ASD in offspring. Further, we will discuss the current limitations of these models as well as potential avenues for future research." @default.
- W4281673471 created "2022-06-13" @default.
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- W4281673471 date "2022-06-02" @default.
- W4281673471 modified "2023-10-14" @default.
- W4281673471 title "Maternal Immune Dysregulation and Autism–Understanding the Role of Cytokines, Chemokines and Autoantibodies" @default.
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- W4281673471 cites W1966773673 @default.
- W4281673471 cites W1972632898 @default.
- W4281673471 cites W1973976214 @default.
- W4281673471 cites W1997691550 @default.
- W4281673471 cites W2004265420 @default.
- W4281673471 cites W2006918320 @default.
- W4281673471 cites W2011447218 @default.
- W4281673471 cites W2012691489 @default.
- W4281673471 cites W2017762661 @default.
- W4281673471 cites W2018685944 @default.
- W4281673471 cites W2022438517 @default.
- W4281673471 cites W2025015805 @default.
- W4281673471 cites W2025052824 @default.
- W4281673471 cites W2029583275 @default.
- W4281673471 cites W2035339084 @default.
- W4281673471 cites W2041380219 @default.
- W4281673471 cites W2046642756 @default.
- W4281673471 cites W2054335925 @default.
- W4281673471 cites W2055596672 @default.
- W4281673471 cites W2061466372 @default.
- W4281673471 cites W2061706174 @default.
- W4281673471 cites W2064176741 @default.
- W4281673471 cites W2064877692 @default.
- W4281673471 cites W2069258818 @default.
- W4281673471 cites W2071843728 @default.
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- W4281673471 cites W2143217444 @default.
- W4281673471 cites W2145656477 @default.
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- W4281673471 cites W2154188802 @default.
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- W4281673471 cites W2164091580 @default.
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- W4281673471 cites W2231387359 @default.
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- W4281673471 cites W2504711446 @default.
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- W4281673471 doi "https://doi.org/10.3389/fpsyt.2022.834910" @default.
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