Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281673499> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4281673499 endingPage "e21506" @default.
- W4281673499 startingPage "e21506" @default.
- W4281673499 abstract "e21506 Background: Malignant melanoma (MM) of mucosal membranes (excluding anus and head and neck) is a rare but aggressive disease with poor outcome. There is little information available on the mechanism of development, risk factors and management of this tumor, mainly due to the low number of cases. Methods: We performed a literature review on MMM (between 1970-2020) with a focus on nonsurgical management and outcome. Results: We identified 9-papers discussing 1500-MM cases. Formerly, for the management of MMM, Dacarbazine, Interferon b, DAV-Feron, Carboplatin, Imatinib, and Paclitaxel were administered. More recently, novel immunotherapeutic and chemotherapeutic medications such as Immune Checkpoint Inhibitors (ICPI) and anti-VEGF agents have been administered in these patients. In 502 patients of metastatic MMM, adding ipilimumab to dacarbazine increased OS from 9.1-to-11.2 months with one year survival increasing from 36.3%-to-47.3 %. For nivolumab & ipilimumab combination therapy in 361 patients with MMM and CMM, MPSF in nivolumab monotherapy was 3-months and 6.2-months (for MMM and CMM, respectively); but in nivo-ipili combination, MPFS was 5.9-months and 11.7-months (for MMM and CMM, respectively). A benefit of bevacizumab addition to platinum-based chemotherapy in patients showing advanced disease on ICPI is unknown; however, combination-therapy may be reasonable if no access to ICPI or autoimmune diseases. Conclusions: MMM patients could benefit from combination of nivolumab to ipilimumab more than monotherapy with either medication alone.[Table: see text]" @default.
- W4281673499 created "2022-06-13" @default.
- W4281673499 creator A5016862869 @default.
- W4281673499 creator A5041138991 @default.
- W4281673499 creator A5042229968 @default.
- W4281673499 creator A5052579493 @default.
- W4281673499 creator A5062656170 @default.
- W4281673499 creator A5067432054 @default.
- W4281673499 creator A5081434117 @default.
- W4281673499 creator A5088098797 @default.
- W4281673499 date "2022-06-01" @default.
- W4281673499 modified "2023-09-26" @default.
- W4281673499 title "Literature on target therapy of malignant melanoma." @default.
- W4281673499 doi "https://doi.org/10.1200/jco.2022.40.16_suppl.e21506" @default.
- W4281673499 hasPublicationYear "2022" @default.
- W4281673499 type Work @default.
- W4281673499 citedByCount "0" @default.
- W4281673499 crossrefType "journal-article" @default.
- W4281673499 hasAuthorship W4281673499A5016862869 @default.
- W4281673499 hasAuthorship W4281673499A5041138991 @default.
- W4281673499 hasAuthorship W4281673499A5042229968 @default.
- W4281673499 hasAuthorship W4281673499A5052579493 @default.
- W4281673499 hasAuthorship W4281673499A5062656170 @default.
- W4281673499 hasAuthorship W4281673499A5067432054 @default.
- W4281673499 hasAuthorship W4281673499A5081434117 @default.
- W4281673499 hasAuthorship W4281673499A5088098797 @default.
- W4281673499 hasConcept C121608353 @default.
- W4281673499 hasConcept C126322002 @default.
- W4281673499 hasConcept C141071460 @default.
- W4281673499 hasConcept C143998085 @default.
- W4281673499 hasConcept C197934379 @default.
- W4281673499 hasConcept C2776694085 @default.
- W4281673499 hasConcept C2776999253 @default.
- W4281673499 hasConcept C2777054765 @default.
- W4281673499 hasConcept C2777658100 @default.
- W4281673499 hasConcept C2777701055 @default.
- W4281673499 hasConcept C2777802072 @default.
- W4281673499 hasConcept C2778239845 @default.
- W4281673499 hasConcept C2780030458 @default.
- W4281673499 hasConcept C2780964509 @default.
- W4281673499 hasConcept C2781186586 @default.
- W4281673499 hasConcept C2781433595 @default.
- W4281673499 hasConcept C2781451048 @default.
- W4281673499 hasConcept C502942594 @default.
- W4281673499 hasConcept C71924100 @default.
- W4281673499 hasConceptScore W4281673499C121608353 @default.
- W4281673499 hasConceptScore W4281673499C126322002 @default.
- W4281673499 hasConceptScore W4281673499C141071460 @default.
- W4281673499 hasConceptScore W4281673499C143998085 @default.
- W4281673499 hasConceptScore W4281673499C197934379 @default.
- W4281673499 hasConceptScore W4281673499C2776694085 @default.
- W4281673499 hasConceptScore W4281673499C2776999253 @default.
- W4281673499 hasConceptScore W4281673499C2777054765 @default.
- W4281673499 hasConceptScore W4281673499C2777658100 @default.
- W4281673499 hasConceptScore W4281673499C2777701055 @default.
- W4281673499 hasConceptScore W4281673499C2777802072 @default.
- W4281673499 hasConceptScore W4281673499C2778239845 @default.
- W4281673499 hasConceptScore W4281673499C2780030458 @default.
- W4281673499 hasConceptScore W4281673499C2780964509 @default.
- W4281673499 hasConceptScore W4281673499C2781186586 @default.
- W4281673499 hasConceptScore W4281673499C2781433595 @default.
- W4281673499 hasConceptScore W4281673499C2781451048 @default.
- W4281673499 hasConceptScore W4281673499C502942594 @default.
- W4281673499 hasConceptScore W4281673499C71924100 @default.
- W4281673499 hasIssue "16_suppl" @default.
- W4281673499 hasLocation W42816734991 @default.
- W4281673499 hasOpenAccess W4281673499 @default.
- W4281673499 hasPrimaryLocation W42816734991 @default.
- W4281673499 hasRelatedWork W2773756552 @default.
- W4281673499 hasRelatedWork W2936603379 @default.
- W4281673499 hasRelatedWork W2947988614 @default.
- W4281673499 hasRelatedWork W2969738919 @default.
- W4281673499 hasRelatedWork W3013144293 @default.
- W4281673499 hasRelatedWork W3035446385 @default.
- W4281673499 hasRelatedWork W4220795664 @default.
- W4281673499 hasRelatedWork W4281673499 @default.
- W4281673499 hasRelatedWork W4283021427 @default.
- W4281673499 hasRelatedWork W4323667931 @default.
- W4281673499 hasVolume "40" @default.
- W4281673499 isParatext "false" @default.
- W4281673499 isRetracted "false" @default.
- W4281673499 workType "article" @default.