Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281678741> ?p ?o ?g. }
- W4281678741 endingPage "108902" @default.
- W4281678741 startingPage "108902" @default.
- W4281678741 abstract "TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous efforts to discover neuroprotective therapeutics for this serious disease, no beneficial outcomes in human clinical trials have been reported to date. Traumatic brain injury (TBI) can occur as a result of any type of trauma, from a simple hit to the head to a penetrating injury to the brain. TBI causes delayed secondary damage events as a result of neurochemical, metabolic, and cellular alterations that account for many of the neurological impairments reported following TBI. We focus on the ability of soluble and cellular inflammatory mediators to promote repair and regeneration versus secondary injury and neurodegeneration in our discussion, which is structured around the kinetics of the immune response to TBI - from immediate triggers through chronic neuroinflammation. Neuroinflammation is caused by traumatic brain injury and can aggravate the progression of tissue deterioration. Immune cells respond acutely to signals from injured cells, develop neuroinflammation, and eventually cause pathology. So neuroinflammation and the immune system could be a target for TBI treatment. However, there are various approaches to the treatment of TBI. This review will provide the literature-based modulation of receptors, ion channels, transporters, and enzymes to attenuate traumatic brain injury." @default.
- W4281678741 created "2022-06-13" @default.
- W4281678741 creator A5016919399 @default.
- W4281678741 creator A5034630023 @default.
- W4281678741 creator A5041907138 @default.
- W4281678741 creator A5050935065 @default.
- W4281678741 date "2022-07-01" @default.
- W4281678741 modified "2023-10-17" @default.
- W4281678741 title "Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches" @default.
- W4281678741 cites W118450234 @default.
- W4281678741 cites W1565819969 @default.
- W4281678741 cites W1573025925 @default.
- W4281678741 cites W1599691548 @default.
- W4281678741 cites W1737200068 @default.
- W4281678741 cites W1772477634 @default.
- W4281678741 cites W1881066497 @default.
- W4281678741 cites W1960466925 @default.
- W4281678741 cites W1973362842 @default.
- W4281678741 cites W1986061017 @default.
- W4281678741 cites W1993917927 @default.
- W4281678741 cites W1994501322 @default.
- W4281678741 cites W2011398156 @default.
- W4281678741 cites W2012541226 @default.
- W4281678741 cites W2019485775 @default.
- W4281678741 cites W2023947841 @default.
- W4281678741 cites W2028448521 @default.
- W4281678741 cites W2036093656 @default.
- W4281678741 cites W2053479959 @default.
- W4281678741 cites W2069893872 @default.
- W4281678741 cites W2070620348 @default.
- W4281678741 cites W2080051897 @default.
- W4281678741 cites W2083004303 @default.
- W4281678741 cites W2085192229 @default.
- W4281678741 cites W2108388278 @default.
- W4281678741 cites W2124439764 @default.
- W4281678741 cites W2128211963 @default.
- W4281678741 cites W2130198578 @default.
- W4281678741 cites W2146037555 @default.
- W4281678741 cites W2146336916 @default.
- W4281678741 cites W2152125093 @default.
- W4281678741 cites W2155989856 @default.
- W4281678741 cites W2205277778 @default.
- W4281678741 cites W2274542647 @default.
- W4281678741 cites W2341136898 @default.
- W4281678741 cites W2413525939 @default.
- W4281678741 cites W2475265111 @default.
- W4281678741 cites W2499640845 @default.
- W4281678741 cites W2508399553 @default.
- W4281678741 cites W2524968585 @default.
- W4281678741 cites W2530559779 @default.
- W4281678741 cites W2547689139 @default.
- W4281678741 cites W2728496947 @default.
- W4281678741 cites W2736269304 @default.
- W4281678741 cites W2737077719 @default.
- W4281678741 cites W2737952451 @default.
- W4281678741 cites W2738410425 @default.
- W4281678741 cites W2745316227 @default.
- W4281678741 cites W2754281752 @default.
- W4281678741 cites W2754554955 @default.
- W4281678741 cites W2761635843 @default.
- W4281678741 cites W2770345329 @default.
- W4281678741 cites W2775366010 @default.
- W4281678741 cites W2789105966 @default.
- W4281678741 cites W2790832821 @default.
- W4281678741 cites W2792862972 @default.
- W4281678741 cites W2802295301 @default.
- W4281678741 cites W2804273600 @default.
- W4281678741 cites W2805886629 @default.
- W4281678741 cites W2807705689 @default.
- W4281678741 cites W2811102541 @default.
- W4281678741 cites W2843091980 @default.
- W4281678741 cites W2884393110 @default.
- W4281678741 cites W2884424144 @default.
- W4281678741 cites W2885748943 @default.
- W4281678741 cites W2888742576 @default.
- W4281678741 cites W2891053092 @default.
- W4281678741 cites W2891999707 @default.
- W4281678741 cites W2893346879 @default.
- W4281678741 cites W2904362105 @default.
- W4281678741 cites W2904498275 @default.
- W4281678741 cites W2905396705 @default.
- W4281678741 cites W2908394481 @default.
- W4281678741 cites W2909395324 @default.
- W4281678741 cites W2913950304 @default.
- W4281678741 cites W2914762501 @default.
- W4281678741 cites W2929439854 @default.
- W4281678741 cites W2943972072 @default.
- W4281678741 cites W2945862226 @default.
- W4281678741 cites W2961425819 @default.
- W4281678741 cites W2963708423 @default.
- W4281678741 cites W2968768229 @default.
- W4281678741 cites W2972010540 @default.
- W4281678741 cites W2975011559 @default.
- W4281678741 cites W2976681202 @default.
- W4281678741 cites W2981644812 @default.
- W4281678741 cites W2989800764 @default.
- W4281678741 cites W2990118693 @default.
- W4281678741 cites W2990649000 @default.