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- W4281679521 abstract "Pancreatic ductal adenocarcinoma (PDAC) represents 90% of all pancreatic cancer cases and shows a high mortality rate among all solid tumors. PDAC is often associated with poor prognosis, due to the late diagnosis that leads to metastasis development, and limited efficacy of available treatments. The tumor microenvironment (TME) represents a reliable source of novel targets for therapy, and even if many of the biological interactions among stromal, immune, and cancer cells that populate the TME have been studied, much more needs to be clarified. The great limitation in the efficacy of current standard chemoterapy is due to both the dense fibrotic inaccessible TME barrier surrounding cancer cells and the immunological evolution from a tumor-suppressor to an immunosuppressive environment. Nevertheless, combinatorial therapies may prove more effective at overcoming resistance mechanisms and achieving tumor cell killing. To achieve this result, a deeper understanding of the pathological mechanisms driving tumor progression and immune escape is required in order to design rationale-based therapeutic strategies. This review aims to summarize the present knowledge about cellular interactions in the TME, with much attention on immunosuppressive functioning and a specific focus on extracellular matrix (ECM) contribution." @default.
- W4281679521 created "2022-06-13" @default.
- W4281679521 creator A5008175617 @default.
- W4281679521 creator A5052556733 @default.
- W4281679521 creator A5085417054 @default.
- W4281679521 creator A5090981936 @default.
- W4281679521 date "2022-05-31" @default.
- W4281679521 modified "2023-10-01" @default.
- W4281679521 title "Understanding Tricky Cellular and Molecular Interactions in Pancreatic Tumor Microenvironment: New Food for Thought" @default.
- W4281679521 cites W1497770306 @default.
- W4281679521 cites W1497915798 @default.
- W4281679521 cites W1562210554 @default.
- W4281679521 cites W1580678794 @default.
- W4281679521 cites W1601995899 @default.
- W4281679521 cites W1759816220 @default.
- W4281679521 cites W1843613114 @default.
- W4281679521 cites W1843651808 @default.
- W4281679521 cites W1849978153 @default.
- W4281679521 cites W1914229765 @default.
- W4281679521 cites W1931508686 @default.
- W4281679521 cites W1946441967 @default.
- W4281679521 cites W1960435484 @default.
- W4281679521 cites W1964704923 @default.
- W4281679521 cites W1971298987 @default.
- W4281679521 cites W1971578941 @default.
- W4281679521 cites W1975426777 @default.
- W4281679521 cites W1977544680 @default.
- W4281679521 cites W1985182657 @default.
- W4281679521 cites W1986608185 @default.
- W4281679521 cites W1986986419 @default.
- W4281679521 cites W1987313243 @default.
- W4281679521 cites W1988013635 @default.
- W4281679521 cites W1989732890 @default.
- W4281679521 cites W1992923049 @default.
- W4281679521 cites W1997929924 @default.
- W4281679521 cites W1998915656 @default.
- W4281679521 cites W2002157461 @default.
- W4281679521 cites W2008658155 @default.
- W4281679521 cites W2008792836 @default.
- W4281679521 cites W2012532871 @default.
- W4281679521 cites W2013093033 @default.
- W4281679521 cites W2021044881 @default.
- W4281679521 cites W2028417270 @default.
- W4281679521 cites W2035818114 @default.
- W4281679521 cites W2044363258 @default.
- W4281679521 cites W2044570560 @default.
- W4281679521 cites W2044682579 @default.
- W4281679521 cites W2046664795 @default.
- W4281679521 cites W2048273322 @default.
- W4281679521 cites W2050698267 @default.
- W4281679521 cites W2051420025 @default.
- W4281679521 cites W2053902262 @default.
- W4281679521 cites W2054472394 @default.
- W4281679521 cites W2056063027 @default.
- W4281679521 cites W2056620799 @default.
- W4281679521 cites W2057594180 @default.
- W4281679521 cites W2058364319 @default.
- W4281679521 cites W2061123122 @default.
- W4281679521 cites W2064777995 @default.
- W4281679521 cites W2066254965 @default.
- W4281679521 cites W2069089843 @default.
- W4281679521 cites W2070026322 @default.
- W4281679521 cites W2071462987 @default.
- W4281679521 cites W2073776582 @default.
- W4281679521 cites W2083495092 @default.
- W4281679521 cites W2086834665 @default.
- W4281679521 cites W2088110734 @default.
- W4281679521 cites W2088609559 @default.
- W4281679521 cites W2092215629 @default.
- W4281679521 cites W2093813223 @default.
- W4281679521 cites W2099092516 @default.
- W4281679521 cites W2100519108 @default.
- W4281679521 cites W2101653483 @default.
- W4281679521 cites W2103746815 @default.
- W4281679521 cites W2107416007 @default.
- W4281679521 cites W2107417920 @default.
- W4281679521 cites W2108775189 @default.
- W4281679521 cites W2109593516 @default.
- W4281679521 cites W2111184201 @default.
- W4281679521 cites W2113589723 @default.
- W4281679521 cites W2118991367 @default.
- W4281679521 cites W2121635719 @default.
- W4281679521 cites W2123149440 @default.
- W4281679521 cites W2124427232 @default.
- W4281679521 cites W2124907948 @default.
- W4281679521 cites W2125987139 @default.
- W4281679521 cites W2130011407 @default.
- W4281679521 cites W2130819559 @default.
- W4281679521 cites W2133321215 @default.
- W4281679521 cites W2143593234 @default.
- W4281679521 cites W2150048477 @default.
- W4281679521 cites W2151253787 @default.
- W4281679521 cites W2151685079 @default.
- W4281679521 cites W2152677909 @default.
- W4281679521 cites W2154790710 @default.
- W4281679521 cites W2155026493 @default.
- W4281679521 cites W2155081123 @default.
- W4281679521 cites W2155268463 @default.
- W4281679521 cites W2161884651 @default.
- W4281679521 cites W2162956874 @default.