FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281684920> ?p ?o ?g. }

• W4281684920 abstract "Abstract Cannabis is increasingly consumed by women of childbearing age, and the reproductive and epigenetic effects are unknown. The purpose of this study was to evaluate the potential epigenetic implications of cannabis use on the female ovarian follicle. Whole-genome methylation was assessed in granulosa cells from 14 matched case-control patients. Exposure status was determined by liquid chromatography–mass spectrometry (LC-MS/MS) measurements of five cannabis-derived phytocannabinoids in follicular fluid. DNA methylation was measured using the Illumina TruSeq Methyl Capture EPIC kit. Differential methylation, pathway analysis and correlation analysis were performed. We identified 3679 differentially methylated sites, with two-thirds affecting coding genes. A hotspot region on chromosome 9 was associated with two genomic features, a zinc-finger protein (ZFP37) and a long non-coding RNA (FAM225B). There were 2214 differentially methylated genomic features, 19 of which have been previously implicated in cannabis-related epigenetic modifications in other organ systems. Pathway analysis revealed enrichment in G protein-coupled receptor signaling, cellular transport, immune response and proliferation. Applying strict criteria, we identified 71 differentially methylated regions, none of which were previously annotated in this context. Finally, correlation analysis revealed 16 unique genomic features affected by cannabis use in a concentration-dependent manner. Of these, the histone methyltransferases SMYD3 and ZFP37 were hypomethylated, possibly implicating histone modifications as well. Herein, we provide the first DNA methylation profile of human granulosa cells exposed to cannabis. With cannabis increasingly legalized worldwide, further investigation into the heritability and functional consequences of these effects is critical for clinical consultation and for legalization guidelines." @default.
• W4281684920 created "2022-06-13" @default.
• W4281684920 creator A5005426292 @default.
• W4281684920 creator A5009839081 @default.
• W4281684920 creator A5025141474 @default.
• W4281684920 creator A5030182635 @default.
• W4281684920 creator A5090281895 @default.
• W4281684920 date "2022-06-08" @default.
• W4281684920 modified "2023-09-30" @default.
• W4281684920 title "Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner" @default.
• W4281684920 cites W137813141 @default.
• W4281684920 cites W1864669634 @default.
• W4281684920 cites W1885974381 @default.
• W4281684920 cites W1937253979 @default.
• W4281684920 cites W1971325935 @default.
• W4281684920 cites W1972610599 @default.
• W4281684920 cites W1976685450 @default.
• W4281684920 cites W1979112369 @default.
• W4281684920 cites W1985020940 @default.
• W4281684920 cites W2000482392 @default.
• W4281684920 cites W2009968727 @default.
• W4281684920 cites W2012586603 @default.
• W4281684920 cites W2015278326 @default.
• W4281684920 cites W2016746345 @default.
• W4281684920 cites W2018838463 @default.
• W4281684920 cites W2033105586 @default.
• W4281684920 cites W2059919630 @default.
• W4281684920 cites W2104911613 @default.
• W4281684920 cites W2107018762 @default.
• W4281684920 cites W2123511827 @default.
• W4281684920 cites W2131374955 @default.
• W4281684920 cites W2134078159 @default.
• W4281684920 cites W2150194502 @default.
• W4281684920 cites W2157915489 @default.
• W4281684920 cites W2169456326 @default.
• W4281684920 cites W2179438025 @default.
• W4281684920 cites W2295466917 @default.
• W4281684920 cites W2327847181 @default.
• W4281684920 cites W2402938017 @default.
• W4281684920 cites W2418073150 @default.
• W4281684920 cites W2461327703 @default.
• W4281684920 cites W2533118965 @default.
• W4281684920 cites W2580334864 @default.
• W4281684920 cites W2619558297 @default.
• W4281684920 cites W2761133874 @default.
• W4281684920 cites W2901672307 @default.
• W4281684920 cites W2905162439 @default.
• W4281684920 cites W2907903780 @default.
• W4281684920 cites W2908470212 @default.
• W4281684920 cites W2938430282 @default.
• W4281684920 cites W2941003197 @default.
• W4281684920 cites W2942837101 @default.
• W4281684920 cites W2944545583 @default.
• W4281684920 cites W2949898193 @default.
• W4281684920 cites W2950467275 @default.
• W4281684920 cites W2967966874 @default.
• W4281684920 cites W2992789362 @default.
• W4281684920 cites W2998033404 @default.
• W4281684920 cites W3018202073 @default.
• W4281684920 cites W3021601606 @default.
• W4281684920 cites W3091085596 @default.
• W4281684920 cites W3109293238 @default.
• W4281684920 cites W3129543960 @default.
• W4281684920 cites W3153161093 @default.
• W4281684920 cites W3157709481 @default.
• W4281684920 cites W590734199 @default.
• W4281684920 cites W2624940842 @default.
• W4281684920 doi "https://doi.org/10.1093/molehr/gaac022" @default.
• W4281684920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35674367" @default.
• W4281684920 hasPublicationYear "2022" @default.
• W4281684920 type Work @default.
• W4281684920 citedByCount "3" @default.
• W4281684920 countsByYear W42816849202023 @default.
• W4281684920 crossrefType "journal-article" @default.
• W4281684920 hasAuthorship W4281684920A5005426292 @default.
• W4281684920 hasAuthorship W4281684920A5009839081 @default.
• W4281684920 hasAuthorship W4281684920A5025141474 @default.
• W4281684920 hasAuthorship W4281684920A5030182635 @default.
• W4281684920 hasAuthorship W4281684920A5090281895 @default.
• W4281684920 hasBestOaLocation W42816849201 @default.
• W4281684920 hasConcept C104317684 @default.
• W4281684920 hasConcept C118552586 @default.
• W4281684920 hasConcept C121912465 @default.
• W4281684920 hasConcept C150194340 @default.
• W4281684920 hasConcept C154253233 @default.
• W4281684920 hasConcept C190727270 @default.
• W4281684920 hasConcept C2777056318 @default.
• W4281684920 hasConcept C33288867 @default.
• W4281684920 hasConcept C41091548 @default.
• W4281684920 hasConcept C54355233 @default.
• W4281684920 hasConcept C64927066 @default.
• W4281684920 hasConcept C71924100 @default.
• W4281684920 hasConcept C86803240 @default.
• W4281684920 hasConcept C91965660 @default.
• W4281684920 hasConceptScore W4281684920C104317684 @default.
• W4281684920 hasConceptScore W4281684920C118552586 @default.
• W4281684920 hasConceptScore W4281684920C121912465 @default.
• W4281684920 hasConceptScore W4281684920C150194340 @default.
• W4281684920 hasConceptScore W4281684920C154253233 @default.
• W4281684920 hasConceptScore W4281684920C190727270 @default.

• next