FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281686095> ?p ?o ?g. }

• W4281686095 endingPage "558" @default.
• W4281686095 startingPage "550" @default.
• W4281686095 abstract "Hemorrhagic shock (HS) is the most common cause of potentially preventable death after traumatic injury. Acute liver injury is an important manifestation of HS. Apoptosis plays an important role in liver injury. Farnesoid X receptor (FXR) can alleviate liver injury. This study aimed to examine the effects of ursodeoxycholic acid (UDCA) on hepatocyte apoptosis in HS and its relationship with the FXR pathway.Mice were randomly divided into 4 groups: sham group, HS group, HS + UDCA group, and FXR (-) + HS + UDCA group. There were 6 mice in each group. As to the model of HS, MAP of 40 ± 5 mmHg was maintained for 1 hour. As to UDCA intervention, UDCA (300mg/kg) was given nasally. Real-time RT-PCR and Western blotting were used to detect changes in the expression level of Caspase-3, Bax, LC3Ⅰ, LC3Ⅱ, Bcl-2, and Beclin-1 in the liver. TUNEL assay was used to detect changes in hepatocyte apoptosis.The expression level of Caspase-3 and Bax in the liver decreased significantly after treatment with UDCA under HS conditions. The expression level of LC3Ⅰ, LC3Ⅱ, Bcl-2, and Beclin-1 in the liver increased significantly after treatment with UDCA under HS conditions. TUNEL positive percentage of liver decreased significantly after treatment with UDCA under HS conditions. In the case of FXR (-), the influence of UDCA was inhibited.These results indicated that UDCA could reduce hepatocyte apoptosis during HS through the FXR pathway." @default.
• W4281686095 created "2022-06-13" @default.
• W4281686095 creator A5005256168 @default.
• W4281686095 creator A5006906521 @default.
• W4281686095 creator A5031206416 @default.
• W4281686095 creator A5042212002 @default.
• W4281686095 creator A5073445299 @default.
• W4281686095 date "2023-07-01" @default.
• W4281686095 modified "2023-10-14" @default.
• W4281686095 title "Ursodeoxycholic Acid (UDCA) Reduces Hepatocyte Apoptosis by Inhibiting Farnesoid X Receptor (FXR) in Hemorrhagic Shock (HS)" @default.
• W4281686095 cites W1563840755 @default.
• W4281686095 cites W2008306859 @default.
• W4281686095 cites W2011356417 @default.
• W4281686095 cites W2015193975 @default.
• W4281686095 cites W2050094423 @default.
• W4281686095 cites W2053792853 @default.
• W4281686095 cites W2088202452 @default.
• W4281686095 cites W2130591775 @default.
• W4281686095 cites W2134295452 @default.
• W4281686095 cites W2156514523 @default.
• W4281686095 cites W2520145724 @default.
• W4281686095 cites W2529857084 @default.
• W4281686095 cites W2566932036 @default.
• W4281686095 cites W2580819059 @default.
• W4281686095 cites W2613326943 @default.
• W4281686095 cites W2733836692 @default.
• W4281686095 cites W2738580736 @default.
• W4281686095 cites W2889014966 @default.
• W4281686095 cites W2890657719 @default.
• W4281686095 cites W2896914840 @default.
• W4281686095 cites W2897662939 @default.
• W4281686095 cites W2907794290 @default.
• W4281686095 cites W2915076701 @default.
• W4281686095 cites W2991086812 @default.
• W4281686095 cites W2991382737 @default.
• W4281686095 cites W3018541786 @default.
• W4281686095 cites W3044880627 @default.
• W4281686095 cites W3048116926 @default.
• W4281686095 cites W3092864624 @default.
• W4281686095 doi "https://doi.org/10.2174/1566524022666220525152811" @default.
• W4281686095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35619282" @default.
• W4281686095 hasPublicationYear "2023" @default.
• W4281686095 type Work @default.
• W4281686095 citedByCount "0" @default.
• W4281686095 crossrefType "journal-article" @default.
• W4281686095 hasAuthorship W4281686095A5005256168 @default.
• W4281686095 hasAuthorship W4281686095A5006906521 @default.
• W4281686095 hasAuthorship W4281686095A5031206416 @default.
• W4281686095 hasAuthorship W4281686095A5042212002 @default.
• W4281686095 hasAuthorship W4281686095A5073445299 @default.
• W4281686095 hasConcept C104317684 @default.
• W4281686095 hasConcept C126322002 @default.
• W4281686095 hasConcept C134018914 @default.
• W4281686095 hasConcept C185592680 @default.
• W4281686095 hasConcept C190283241 @default.
• W4281686095 hasConcept C196795494 @default.
• W4281686095 hasConcept C202751555 @default.
• W4281686095 hasConcept C203862802 @default.
• W4281686095 hasConcept C2776200302 @default.
• W4281686095 hasConcept C2776637226 @default.
• W4281686095 hasConcept C2780965833 @default.
• W4281686095 hasConcept C55493867 @default.
• W4281686095 hasConcept C63932345 @default.
• W4281686095 hasConcept C71924100 @default.
• W4281686095 hasConcept C86339819 @default.
• W4281686095 hasConcept C98274493 @default.
• W4281686095 hasConceptScore W4281686095C104317684 @default.
• W4281686095 hasConceptScore W4281686095C126322002 @default.
• W4281686095 hasConceptScore W4281686095C134018914 @default.
• W4281686095 hasConceptScore W4281686095C185592680 @default.
• W4281686095 hasConceptScore W4281686095C190283241 @default.
• W4281686095 hasConceptScore W4281686095C196795494 @default.
• W4281686095 hasConceptScore W4281686095C202751555 @default.
• W4281686095 hasConceptScore W4281686095C203862802 @default.
• W4281686095 hasConceptScore W4281686095C2776200302 @default.
• W4281686095 hasConceptScore W4281686095C2776637226 @default.
• W4281686095 hasConceptScore W4281686095C2780965833 @default.
• W4281686095 hasConceptScore W4281686095C55493867 @default.
• W4281686095 hasConceptScore W4281686095C63932345 @default.
• W4281686095 hasConceptScore W4281686095C71924100 @default.
• W4281686095 hasConceptScore W4281686095C86339819 @default.
• W4281686095 hasConceptScore W4281686095C98274493 @default.
• W4281686095 hasFunder F4320306650 @default.
• W4281686095 hasFunder F4320321001 @default.
• W4281686095 hasFunder F4320322919 @default.
• W4281686095 hasIssue "6" @default.
• W4281686095 hasLocation W42816860951 @default.
• W4281686095 hasLocation W42816860952 @default.
• W4281686095 hasOpenAccess W4281686095 @default.
• W4281686095 hasPrimaryLocation W42816860951 @default.
• W4281686095 hasRelatedWork W2094423915 @default.
• W4281686095 hasRelatedWork W2360970443 @default.
• W4281686095 hasRelatedWork W2364920883 @default.
• W4281686095 hasRelatedWork W2368248350 @default.
• W4281686095 hasRelatedWork W2376666030 @default.
• W4281686095 hasRelatedWork W2377250215 @default.
• W4281686095 hasRelatedWork W2473636829 @default.
• W4281686095 hasRelatedWork W2748952813 @default.

• next