Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281687039> ?p ?o ?g. }
- W4281687039 abstract "Increasing clinical data on sex-related differences in drug efficacy and toxicity has highlighted the importance of understanding the impact of sex on drug pharmacokinetics and pharmacodynamics. Intrinsic differences between males and females, such as different CYP enzyme activity, drug transporter expression or levels of sex hormones can all contribute to different responses to medications. However, most studies do not include sex-specific investigations, leading to lack of sex-disaggregated pharmacokinetic and pharmacodynamic data. Based available literature, the potential influence of sex on exposure-response relationship has not been fully explored for many drugs used in clinical practice, though population-based pharmacokinetic/pharmacodynamic modelling is well-placed to explore this effect. The aim of this review is to highlight existing knowledge gaps regarding the effect of sex on clinical outcomes, thereby proposing future research direction for the drugs with significant sex differences. Based on evaluated drugs encompassing all therapeutic areas, 25 drugs demonstrated a clinically meaningful sex differences in drug exposure (characterised by ≥ 50% change in drug exposure) and this altered PK was correlated with differential response." @default.
- W4281687039 created "2022-06-13" @default.
- W4281687039 creator A5004690007 @default.
- W4281687039 creator A5021022406 @default.
- W4281687039 creator A5054452155 @default.
- W4281687039 creator A5064652511 @default.
- W4281687039 creator A5067558581 @default.
- W4281687039 date "2022-06-06" @default.
- W4281687039 modified "2023-10-15" @default.
- W4281687039 title "Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy" @default.
- W4281687039 cites W124776337 @default.
- W4281687039 cites W139294603 @default.
- W4281687039 cites W1532130844 @default.
- W4281687039 cites W1543790510 @default.
- W4281687039 cites W1549428774 @default.
- W4281687039 cites W1557131785 @default.
- W4281687039 cites W1892429132 @default.
- W4281687039 cites W1918748466 @default.
- W4281687039 cites W1967105697 @default.
- W4281687039 cites W1976095389 @default.
- W4281687039 cites W1979067391 @default.
- W4281687039 cites W1980076801 @default.
- W4281687039 cites W1981383266 @default.
- W4281687039 cites W1982916373 @default.
- W4281687039 cites W1984682123 @default.
- W4281687039 cites W1984898035 @default.
- W4281687039 cites W1986693537 @default.
- W4281687039 cites W1988098374 @default.
- W4281687039 cites W1988313152 @default.
- W4281687039 cites W2001277626 @default.
- W4281687039 cites W2002699392 @default.
- W4281687039 cites W2004038693 @default.
- W4281687039 cites W2014117711 @default.
- W4281687039 cites W2014207904 @default.
- W4281687039 cites W2016926526 @default.
- W4281687039 cites W2017331060 @default.
- W4281687039 cites W2018283808 @default.
- W4281687039 cites W2020765733 @default.
- W4281687039 cites W2030616474 @default.
- W4281687039 cites W2030973274 @default.
- W4281687039 cites W2034113803 @default.
- W4281687039 cites W2036296711 @default.
- W4281687039 cites W2040016931 @default.
- W4281687039 cites W2057221507 @default.
- W4281687039 cites W2061155379 @default.
- W4281687039 cites W2061914417 @default.
- W4281687039 cites W2062756251 @default.
- W4281687039 cites W2062862789 @default.
- W4281687039 cites W2064883756 @default.
- W4281687039 cites W2066490209 @default.
- W4281687039 cites W2074050257 @default.
- W4281687039 cites W2077898677 @default.
- W4281687039 cites W2080080131 @default.
- W4281687039 cites W2080340920 @default.
- W4281687039 cites W2091289833 @default.
- W4281687039 cites W2102858241 @default.
- W4281687039 cites W2106474407 @default.
- W4281687039 cites W2107751156 @default.
- W4281687039 cites W2111738175 @default.
- W4281687039 cites W2114673951 @default.
- W4281687039 cites W2117521578 @default.
- W4281687039 cites W2120444754 @default.
- W4281687039 cites W2121329960 @default.
- W4281687039 cites W2125938464 @default.
- W4281687039 cites W2126867245 @default.
- W4281687039 cites W2128085120 @default.
- W4281687039 cites W2140455411 @default.
- W4281687039 cites W2151384577 @default.
- W4281687039 cites W2155634239 @default.
- W4281687039 cites W2170385855 @default.
- W4281687039 cites W2211642628 @default.
- W4281687039 cites W22834980 @default.
- W4281687039 cites W2298795674 @default.
- W4281687039 cites W2315147554 @default.
- W4281687039 cites W2345707108 @default.
- W4281687039 cites W2404617970 @default.
- W4281687039 cites W2404767836 @default.
- W4281687039 cites W2416067055 @default.
- W4281687039 cites W2586337928 @default.
- W4281687039 cites W2767172096 @default.
- W4281687039 cites W2769797405 @default.
- W4281687039 cites W2808520288 @default.
- W4281687039 cites W2810081096 @default.
- W4281687039 cites W2836684335 @default.
- W4281687039 cites W2909003059 @default.
- W4281687039 cites W2980659545 @default.
- W4281687039 cites W2982535719 @default.
- W4281687039 cites W2998965924 @default.
- W4281687039 cites W3009358518 @default.
- W4281687039 cites W3022053221 @default.
- W4281687039 cites W3033773215 @default.
- W4281687039 cites W3154498658 @default.
- W4281687039 cites W36067026 @default.
- W4281687039 cites W68475027 @default.
- W4281687039 cites W801104115 @default.
- W4281687039 doi "https://doi.org/10.3389/fphar.2022.874606" @default.
- W4281687039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35734405" @default.
- W4281687039 hasPublicationYear "2022" @default.
- W4281687039 type Work @default.
- W4281687039 citedByCount "2" @default.