FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281690213> ?p ?o ?g. }

• W4281690213 endingPage "718" @default.
• W4281690213 startingPage "718" @default.
• W4281690213 abstract "Background and aim: Ever since the discovery of tumor-associated immune cells, there has been growing interest in the understanding of the mechanisms underlying the crosstalk between these cells and tumor cells. A seed and soil approach has been recently introduced to describe the glioblastoma (GBM) landscape: tumor microenvironments act as fertile soil and interact with the seed (glial and stem cells compartment). In the following article, we provide a systematic review of the current evidence pertaining to the characterization of glioma-associated macrophages and microglia (GAMs) and microglia and macrophage cells in the glioma tumor microenvironment (TME). Methods: An online literature search was launched on PubMed Medline and Scopus using the following research string: ((Glioma associated macrophages OR GAM OR Microglia) AND (glioblastoma tumor microenvironment OR TME)). The last search for articles pertinent to the topic was conducted in February 2022. Results: The search of the literature yielded a total of 349 results. A total of 235 studies were found to be relevant to our research question and were assessed for eligibility. Upon a full-text review, 58 articles were included in the review. The reviewed papers were further divided into three categories based on their focus: (1) Microglia maintenance of immunological homeostasis and protection against autoimmunity; (2) Microglia crosstalk with dedifferentiated and stem-like glioblastoma cells; (3) Microglia migratory behavior and its activation pattern. Conclusions: Aggressive growth, inevitable recurrence, and scarce response to immunotherapies are driving the necessity to focus on the GBM TME from a different perspective to possibly disentangle its role as a fertile 'soil' for tumor progression and identify within it feasible therapeutic targets. Against this background, our systematic review confirmed microglia to play a paramount role in promoting GBM progression and relapse after treatments. The correct and extensive understanding of microglia-glioma crosstalk could help in understanding the physiopathology of this complex disease, possibly opening scenarios for improvement of treatments." @default.
• W4281690213 created "2022-06-13" @default.
• W4281690213 creator A5001973740 @default.
• W4281690213 creator A5016519754 @default.
• W4281690213 creator A5022486866 @default.
• W4281690213 creator A5029381127 @default.
• W4281690213 creator A5042445499 @default.
• W4281690213 creator A5079396583 @default.
• W4281690213 date "2022-05-31" @default.
• W4281690213 modified "2023-10-05" @default.
• W4281690213 title "Glioma-Associated Microglia Characterization in the Glioblastoma Microenvironment through a ‘Seed-and Soil’ Approach: A Systematic Review" @default.
• W4281690213 cites W1526121022 @default.
• W4281690213 cites W1530763983 @default.
• W4281690213 cites W1596721271 @default.
• W4281690213 cites W1791497256 @default.
• W4281690213 cites W1815157104 @default.
• W4281690213 cites W1850978620 @default.
• W4281690213 cites W1858380481 @default.
• W4281690213 cites W1911385032 @default.
• W4281690213 cites W1960665172 @default.
• W4281690213 cites W1967462192 @default.
• W4281690213 cites W1970667811 @default.
• W4281690213 cites W1973226767 @default.
• W4281690213 cites W1980485314 @default.
• W4281690213 cites W2032249604 @default.
• W4281690213 cites W2044184535 @default.
• W4281690213 cites W2050007032 @default.
• W4281690213 cites W2051003757 @default.
• W4281690213 cites W2067134374 @default.
• W4281690213 cites W2077636669 @default.
• W4281690213 cites W2093005409 @default.
• W4281690213 cites W2124836944 @default.
• W4281690213 cites W2128083415 @default.
• W4281690213 cites W2142340543 @default.
• W4281690213 cites W2169011598 @default.
• W4281690213 cites W2192314619 @default.
• W4281690213 cites W2287464593 @default.
• W4281690213 cites W2428936938 @default.
• W4281690213 cites W2511897228 @default.
• W4281690213 cites W2547097019 @default.
• W4281690213 cites W2571044792 @default.
• W4281690213 cites W2594844632 @default.
• W4281690213 cites W2598034962 @default.
• W4281690213 cites W2604996547 @default.
• W4281690213 cites W2618874742 @default.
• W4281690213 cites W2619855900 @default.
• W4281690213 cites W2736056364 @default.
• W4281690213 cites W2740090202 @default.
• W4281690213 cites W2743205823 @default.
• W4281690213 cites W2748703947 @default.
• W4281690213 cites W2765248112 @default.
• W4281690213 cites W2767839033 @default.
• W4281690213 cites W2790003308 @default.
• W4281690213 cites W2790467395 @default.
• W4281690213 cites W2793168602 @default.
• W4281690213 cites W2800993426 @default.
• W4281690213 cites W2802252907 @default.
• W4281690213 cites W2804930677 @default.
• W4281690213 cites W2806121532 @default.
• W4281690213 cites W2810219671 @default.
• W4281690213 cites W2888701389 @default.
• W4281690213 cites W2890896123 @default.
• W4281690213 cites W2899509963 @default.
• W4281690213 cites W2902634143 @default.
• W4281690213 cites W2904556927 @default.
• W4281690213 cites W2917960773 @default.
• W4281690213 cites W2922585042 @default.
• W4281690213 cites W2934484757 @default.
• W4281690213 cites W2940050172 @default.
• W4281690213 cites W2946861939 @default.
• W4281690213 cites W2947006916 @default.
• W4281690213 cites W2949306754 @default.
• W4281690213 cites W2951880440 @default.
• W4281690213 cites W2979524748 @default.
• W4281690213 cites W2982160786 @default.
• W4281690213 cites W2992965996 @default.
• W4281690213 cites W2995682532 @default.
• W4281690213 cites W3005312626 @default.
• W4281690213 cites W3005843792 @default.
• W4281690213 cites W3005916578 @default.
• W4281690213 cites W3006133653 @default.
• W4281690213 cites W3022149235 @default.
• W4281690213 cites W3030339055 @default.
• W4281690213 cites W3030448313 @default.
• W4281690213 cites W3036950360 @default.
• W4281690213 cites W3092866843 @default.
• W4281690213 cites W3095068999 @default.
• W4281690213 cites W3099876323 @default.
• W4281690213 cites W3102283691 @default.
• W4281690213 cites W3110998507 @default.
• W4281690213 cites W3117948387 @default.
• W4281690213 cites W3120298769 @default.
• W4281690213 cites W3126978684 @default.
• W4281690213 cites W3127244735 @default.
• W4281690213 cites W3132004441 @default.
• W4281690213 cites W3133473208 @default.
• W4281690213 cites W3135277089 @default.
• W4281690213 cites W3155006664 @default.

• next