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- W4281692005 abstract "Enterococcus faecalis (E. faecalis) is an opportunistic multidrug-resistant (MDR) pathogen found in the guts of humans and farmed animals. Due to the occurrence of (MDR) strain there is an urgent need to look for an alternative treatment approach. E. faecalis is a Gram-positive bacterium, which is among the most prevalent multidrug resistant hospital pathogens. Its ability to develop quorum sensing (QS) mediated biofilm formation further exacerbates the pathogenicity and triggers lifethreatening infections. Therefore, developing a suitable remedy for curing E. faecalis mediated enterococcal infections is an arduous task. Several putative virulence factors and proteins are involved in the development of biofilms in E. faecalis. Such proteins often play important roles in virulence, disease, and colonization by pathogens. The elucidation of the structure-function relationship of such protein drug targets and the interacting compounds could provide an attractive paradigm towards developing structure-based drugs against E. faecalis. This review provides a comprehensive overview of the current status, enigmas that warrant further studies, and the prospects toward alleviating the antibiotic resistance in E. faecalis. Specifically, the role of biofilm and quorum sensing (QS) in the emergence of MDR strains had been elaborated along with the importance of the protein drug targets involved in both the processes." @default.
- W4281692005 created "2022-06-13" @default.
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- W4281692005 date "2022-04-01" @default.
- W4281692005 modified "2023-09-26" @default.
- W4281692005 title "Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis" @default.
- W4281692005 cites W1488210495 @default.
- W4281692005 cites W1598317050 @default.
- W4281692005 cites W1945796226 @default.
- W4281692005 cites W1963626859 @default.
- W4281692005 cites W1964202468 @default.
- W4281692005 cites W1967023708 @default.
- W4281692005 cites W1968252808 @default.
- W4281692005 cites W1968463338 @default.
- W4281692005 cites W1971724498 @default.
- W4281692005 cites W1977069647 @default.
- W4281692005 cites W1980660341 @default.
- W4281692005 cites W1987400078 @default.
- W4281692005 cites W1989224306 @default.
- W4281692005 cites W1989797392 @default.
- W4281692005 cites W1991924027 @default.
- W4281692005 cites W1994426944 @default.
- W4281692005 cites W1996624451 @default.
- W4281692005 cites W1997086033 @default.
- W4281692005 cites W1997520863 @default.
- W4281692005 cites W2000387332 @default.
- W4281692005 cites W2000993970 @default.
- W4281692005 cites W2006805047 @default.
- W4281692005 cites W2012772141 @default.
- W4281692005 cites W2014219943 @default.
- W4281692005 cites W2016935145 @default.
- W4281692005 cites W2019325003 @default.
- W4281692005 cites W2027375167 @default.
- W4281692005 cites W2027831845 @default.
- W4281692005 cites W2033607922 @default.
- W4281692005 cites W2036755724 @default.
- W4281692005 cites W2046454404 @default.
- W4281692005 cites W2049681983 @default.
- W4281692005 cites W2050049838 @default.
- W4281692005 cites W2050213935 @default.
- W4281692005 cites W2052567202 @default.
- W4281692005 cites W2053769493 @default.
- W4281692005 cites W2056892325 @default.
- W4281692005 cites W2057453880 @default.
- W4281692005 cites W2061878956 @default.
- W4281692005 cites W2061972317 @default.
- W4281692005 cites W2067348974 @default.
- W4281692005 cites W2067835715 @default.
- W4281692005 cites W2070300719 @default.
- W4281692005 cites W2071982043 @default.
- W4281692005 cites W2072409597 @default.
- W4281692005 cites W2073233593 @default.
- W4281692005 cites W2081439047 @default.
- W4281692005 cites W2084266616 @default.
- W4281692005 cites W2084622748 @default.
- W4281692005 cites W2084947014 @default.
- W4281692005 cites W2088726933 @default.
- W4281692005 cites W2099403356 @default.
- W4281692005 cites W2100414911 @default.
- W4281692005 cites W2101757691 @default.
- W4281692005 cites W2104768590 @default.
- W4281692005 cites W2105766306 @default.
- W4281692005 cites W2107978429 @default.
- W4281692005 cites W2112886497 @default.
- W4281692005 cites W2115542273 @default.
- W4281692005 cites W2119507371 @default.
- W4281692005 cites W2123386797 @default.
- W4281692005 cites W2123958668 @default.
- W4281692005 cites W2126828161 @default.
- W4281692005 cites W2126922170 @default.
- W4281692005 cites W2127347791 @default.
- W4281692005 cites W2127732228 @default.
- W4281692005 cites W2131229428 @default.
- W4281692005 cites W2132159355 @default.
- W4281692005 cites W2135327236 @default.
- W4281692005 cites W2136484902 @default.
- W4281692005 cites W2136723682 @default.
- W4281692005 cites W2137576925 @default.
- W4281692005 cites W2138670572 @default.
- W4281692005 cites W2139549796 @default.
- W4281692005 cites W2140405224 @default.
- W4281692005 cites W2144440398 @default.
- W4281692005 cites W2151649467 @default.
- W4281692005 cites W2153038669 @default.
- W4281692005 cites W2155552706 @default.
- W4281692005 cites W2155855168 @default.
- W4281692005 cites W2157641883 @default.
- W4281692005 cites W2157705749 @default.
- W4281692005 cites W2159485287 @default.