FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281693713> ?p ?o ?g. }

• W4281693713 abstract "Non-alcoholic fatty liver disease (NAFLD) is a broad term encompassing hepatic steatosis and non-alcoholic steatohepatitis (NASH), a form of chronic hepatitis. This may, unfortunately, lead to terminal complications like cirrhosis and hepatocellular carcinoma (HCC). NAFLD is strongly associated with obesity, type 2 diabetes (T2DM), hypertension, and metabolic syndrome. The growing prevalence of NAFLD, its associated conditions, and its complications are alarming. The insulin sensitizer group thiazolidinediones has shown some therapeutic benefits in this condition. This systematic review is intended to focus on the clinical efficacy of this group in patients with NAFLD, employing PubMed, Google Scholar, and the Cochrane Library as databases. We discovered 10 randomized control trials (RCTs; nine involving pioglitazone and one involving rosiglitazone) involving 887 participants. All studies varied in duration from 6 to 24 months. Most of the involved trials had a small number of participants, and the intrinsic quality of the studies was mixed. Pioglitazone consistently improved histological parameters and normalized liver transaminases, although evidence supporting the benefits of other drugs in this class was minimal. Thiazolidinediones, particularly pioglitazone, have proven efficacious in patients with NAFLD/NASH. However, more extensive trials need to be carried out to investigate this drug class's benefits further. Unfortunately, this drug has attendant side effects like weight gain and fractures, limiting its widespread use; hence, careful selection for likely candidates is imperative." @default.
• W4281693713 created "2022-06-13" @default.
• W4281693713 creator A5039094892 @default.
• W4281693713 creator A5060796033 @default.
• W4281693713 date "2022-05-27" @default.
• W4281693713 modified "2023-10-04" @default.
• W4281693713 title "The Role of Thiazolidinediones in the Amelioration of Nonalcoholic Fatty Liver Disease: A Systematic Review" @default.
• W4281693713 cites W1622799587 @default.
• W4281693713 cites W1868946762 @default.
• W4281693713 cites W2006591225 @default.
• W4281693713 cites W2007516026 @default.
• W4281693713 cites W2014025452 @default.
• W4281693713 cites W2019093082 @default.
• W4281693713 cites W2019280401 @default.
• W4281693713 cites W2029811522 @default.
• W4281693713 cites W2038961236 @default.
• W4281693713 cites W2049633956 @default.
• W4281693713 cites W2062812115 @default.
• W4281693713 cites W2067740038 @default.
• W4281693713 cites W2069412892 @default.
• W4281693713 cites W2087829753 @default.
• W4281693713 cites W2097794068 @default.
• W4281693713 cites W2103156933 @default.
• W4281693713 cites W2142844314 @default.
• W4281693713 cites W2156098321 @default.
• W4281693713 cites W2162078466 @default.
• W4281693713 cites W2273038955 @default.
• W4281693713 cites W2316193238 @default.
• W4281693713 cites W2408388024 @default.
• W4281693713 cites W2417747327 @default.
• W4281693713 cites W246286872 @default.
• W4281693713 cites W2470709274 @default.
• W4281693713 cites W2516295949 @default.
• W4281693713 cites W2518856513 @default.
• W4281693713 cites W2537542066 @default.
• W4281693713 cites W2734724639 @default.
• W4281693713 cites W2777780841 @default.
• W4281693713 cites W2913071400 @default.
• W4281693713 cites W2938668766 @default.
• W4281693713 cites W2963543751 @default.
• W4281693713 cites W2995030404 @default.
• W4281693713 cites W3088022974 @default.
• W4281693713 cites W3117083078 @default.
• W4281693713 cites W3138288621 @default.
• W4281693713 cites W4293860580 @default.
• W4281693713 cites W4294215472 @default.
• W4281693713 cites W4376849750 @default.
• W4281693713 doi "https://doi.org/10.7759/cureus.25380" @default.
• W4281693713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35765391" @default.
• W4281693713 hasPublicationYear "2022" @default.
• W4281693713 type Work @default.
• W4281693713 citedByCount "4" @default.
• W4281693713 countsByYear W42816937132023 @default.
• W4281693713 crossrefType "journal-article" @default.
• W4281693713 hasAuthorship W4281693713A5039094892 @default.
• W4281693713 hasAuthorship W4281693713A5060796033 @default.
• W4281693713 hasBestOaLocation W42816937131 @default.
• W4281693713 hasConcept C126322002 @default.
• W4281693713 hasConcept C134018914 @default.
• W4281693713 hasConcept C168563851 @default.
• W4281693713 hasConcept C2776175330 @default.
• W4281693713 hasConcept C2776478404 @default.
• W4281693713 hasConcept C2776954865 @default.
• W4281693713 hasConcept C2777180221 @default.
• W4281693713 hasConcept C2777214474 @default.
• W4281693713 hasConcept C2778019345 @default.
• W4281693713 hasConcept C2778384471 @default.
• W4281693713 hasConcept C2778772119 @default.
• W4281693713 hasConcept C2779134260 @default.
• W4281693713 hasConcept C2779306644 @default.
• W4281693713 hasConcept C2779478299 @default.
• W4281693713 hasConcept C2780152017 @default.
• W4281693713 hasConcept C2780578515 @default.
• W4281693713 hasConcept C511355011 @default.
• W4281693713 hasConcept C535046627 @default.
• W4281693713 hasConcept C555293320 @default.
• W4281693713 hasConcept C71924100 @default.
• W4281693713 hasConcept C90924648 @default.
• W4281693713 hasConceptScore W4281693713C126322002 @default.
• W4281693713 hasConceptScore W4281693713C134018914 @default.
• W4281693713 hasConceptScore W4281693713C168563851 @default.
• W4281693713 hasConceptScore W4281693713C2776175330 @default.
• W4281693713 hasConceptScore W4281693713C2776478404 @default.
• W4281693713 hasConceptScore W4281693713C2776954865 @default.
• W4281693713 hasConceptScore W4281693713C2777180221 @default.
• W4281693713 hasConceptScore W4281693713C2777214474 @default.
• W4281693713 hasConceptScore W4281693713C2778019345 @default.
• W4281693713 hasConceptScore W4281693713C2778384471 @default.
• W4281693713 hasConceptScore W4281693713C2778772119 @default.
• W4281693713 hasConceptScore W4281693713C2779134260 @default.
• W4281693713 hasConceptScore W4281693713C2779306644 @default.
• W4281693713 hasConceptScore W4281693713C2779478299 @default.
• W4281693713 hasConceptScore W4281693713C2780152017 @default.
• W4281693713 hasConceptScore W4281693713C2780578515 @default.
• W4281693713 hasConceptScore W4281693713C511355011 @default.
• W4281693713 hasConceptScore W4281693713C535046627 @default.
• W4281693713 hasConceptScore W4281693713C555293320 @default.
• W4281693713 hasConceptScore W4281693713C71924100 @default.
• W4281693713 hasConceptScore W4281693713C90924648 @default.
• W4281693713 hasLocation W42816937131 @default.

• next