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- W4281695553 endingPage "111442" @default.
- W4281695553 startingPage "111442" @default.
- W4281695553 abstract "Flavonoids possess an impressive therapeutic potential, thereby imparting them a nutraceutical character. As it becomes increasingly common to consume foods associated with healing properties, it is imperative to understand the associations of different foods with different classes of nutraceutic compounds, and their mechanisms of therapeutic action. At the same time, it is important to address the limitations thereof so that plausible future directions may be drawn. This review summarizes the food associations of flavonoids, and discusses the mechanisms responsible for imparting them their nutraceutic properties, detailing the nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway, inhibition of inflammatory signaling pathways such as toll-like receptor (TLR), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), cyclooxygenase 2 (COX-2) and lipoxygenase-2 (LOX-2) mediators. Further on, the review explains the mechanism of flavonoids metabolism, reasons for low bioavailability and thereafter recapitulates the role of technological interventions to overcome the limitations, with a particular focus on nanoformulations that utilize the synergy between flavonoids and biocompatible materials used as nanocarriers, as reported in works spanning over a decade. It is the Generally Recognized as Safe (GRAS) classified carriers that will become the basis for developing functional formulations. It is promisingly noteworthy that some flavonoid formulations have been commercialized and mentioned therein. Such commercially viable and safe for consumption technological applications pave way for bringing science to the table, and add value to the innate properties of flavonoids." @default.
- W4281695553 created "2022-06-13" @default.
- W4281695553 creator A5013640474 @default.
- W4281695553 creator A5080916492 @default.
- W4281695553 creator A5083558391 @default.
- W4281695553 date "2022-07-01" @default.
- W4281695553 modified "2023-10-12" @default.
- W4281695553 title "Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations" @default.
- W4281695553 cites W1420784649 @default.
- W4281695553 cites W1882722575 @default.
- W4281695553 cites W1914622032 @default.
- W4281695553 cites W1968607632 @default.
- W4281695553 cites W1975495765 @default.
- W4281695553 cites W1979175922 @default.
- W4281695553 cites W1981930609 @default.
- W4281695553 cites W1981998676 @default.
- W4281695553 cites W1984465123 @default.
- W4281695553 cites W1986300508 @default.
- W4281695553 cites W1987018240 @default.
- W4281695553 cites W1996315798 @default.
- W4281695553 cites W2003273638 @default.
- W4281695553 cites W2005782639 @default.
- W4281695553 cites W2005810350 @default.
- W4281695553 cites W2012876663 @default.
- W4281695553 cites W2015043249 @default.
- W4281695553 cites W2021812778 @default.
- W4281695553 cites W2023575910 @default.
- W4281695553 cites W2026243801 @default.
- W4281695553 cites W2028703802 @default.
- W4281695553 cites W2035248522 @default.
- W4281695553 cites W2041100273 @default.
- W4281695553 cites W2042232868 @default.
- W4281695553 cites W2053115631 @default.
- W4281695553 cites W2056970943 @default.
- W4281695553 cites W2057241440 @default.
- W4281695553 cites W2059052125 @default.
- W4281695553 cites W2067670322 @default.
- W4281695553 cites W2068634848 @default.
- W4281695553 cites W2070110861 @default.
- W4281695553 cites W2074064736 @default.
- W4281695553 cites W2080304600 @default.
- W4281695553 cites W2083072576 @default.
- W4281695553 cites W2084342405 @default.
- W4281695553 cites W2087242576 @default.
- W4281695553 cites W2090548281 @default.
- W4281695553 cites W2091132460 @default.
- W4281695553 cites W2093576329 @default.
- W4281695553 cites W2096367415 @default.
- W4281695553 cites W2096741399 @default.
- W4281695553 cites W2103380788 @default.
- W4281695553 cites W2105099990 @default.
- W4281695553 cites W2106357931 @default.
- W4281695553 cites W2113140652 @default.
- W4281695553 cites W2116060738 @default.
- W4281695553 cites W2119661928 @default.
- W4281695553 cites W2122320945 @default.
- W4281695553 cites W2125156265 @default.
- W4281695553 cites W2127479306 @default.
- W4281695553 cites W2132052735 @default.
- W4281695553 cites W2133061356 @default.
- W4281695553 cites W2142973990 @default.
- W4281695553 cites W2150891773 @default.
- W4281695553 cites W2155517596 @default.
- W4281695553 cites W2160340213 @default.
- W4281695553 cites W2163546475 @default.
- W4281695553 cites W2178242722 @default.
- W4281695553 cites W2221097878 @default.
- W4281695553 cites W2266928527 @default.
- W4281695553 cites W2272075833 @default.
- W4281695553 cites W2282670662 @default.
- W4281695553 cites W2286441035 @default.
- W4281695553 cites W2294020897 @default.
- W4281695553 cites W2296554133 @default.
- W4281695553 cites W2315782077 @default.
- W4281695553 cites W2331778217 @default.
- W4281695553 cites W2340801875 @default.
- W4281695553 cites W2431509689 @default.
- W4281695553 cites W2460862632 @default.
- W4281695553 cites W2504001075 @default.
- W4281695553 cites W2560550958 @default.
- W4281695553 cites W2570604634 @default.
- W4281695553 cites W2600420453 @default.
- W4281695553 cites W2685809528 @default.
- W4281695553 cites W2697871094 @default.
- W4281695553 cites W2762490959 @default.
- W4281695553 cites W2765596630 @default.
- W4281695553 cites W2766318757 @default.
- W4281695553 cites W2769756335 @default.
- W4281695553 cites W2771686049 @default.
- W4281695553 cites W2784011054 @default.
- W4281695553 cites W2790561339 @default.
- W4281695553 cites W2790654889 @default.
- W4281695553 cites W2793632245 @default.
- W4281695553 cites W2793665524 @default.
- W4281695553 cites W2803594138 @default.
- W4281695553 cites W2804725278 @default.
- W4281695553 cites W2890580142 @default.
- W4281695553 cites W2891092376 @default.