Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281696128> ?p ?o ?g. }
- W4281696128 endingPage "8230" @default.
- W4281696128 startingPage "8221" @default.
- W4281696128 abstract "The penetration of organophosphate triesters (tri-OPEs) and diesters (di-OPEs) across the blood-brain barrier and their influencing factors remain unclear in humans. In this study, 21 tri-OPEs and 8 di-OPEs were measured in 288 paired serum and cerebrospinal fluid (CSF) samples collected in Jinan, China. Six tri-OPEs were frequently detected in both serum and CSF, with median concentrations ranging from 0.062 to 1.62 and 0.042-1.11 ng/mL, respectively. Their penetration efficiencies across the blood-CSF barrier (BCSFB) (RCSF/serum, CCSF/Cserum) were calculated at 0.667-2.80, and these efficiencies first increased and then decreased with their log Kow values. The reduced penetration efficiencies of triphenyl phosphate (TPHP) and 2-ethylhexyl diphenyl phosphate (EHDPP) may be attributed to their strong binding affinities for human serum albumin and p-glycoprotein due to their high hydrophobicity and aryl structure, as indicated by molecular docking. This suggests that active efflux transport may be involved in the penetration of TPHP and EHDPP in addition to passive diffusion similar to the other four tri-OPEs. Di-OPEs were found in few serum samples and even fewer CSF samples, indicating their limited BCSFB permeability. This may be due to their high polarity, low hydrophobicity, and ionic state in blood. This study has important implications for understanding the neurotoxicity of tri-OPEs and di-OPEs and the underlying mechanisms." @default.
- W4281696128 created "2022-06-13" @default.
- W4281696128 creator A5000385063 @default.
- W4281696128 creator A5021187018 @default.
- W4281696128 creator A5029171095 @default.
- W4281696128 creator A5050146220 @default.
- W4281696128 creator A5055615065 @default.
- W4281696128 date "2022-06-06" @default.
- W4281696128 modified "2023-10-14" @default.
- W4281696128 title "Penetration of Organophosphate Triesters and Diesters across the Blood–Cerebrospinal Fluid Barrier: Efficiencies, Impact Factors, and Mechanisms" @default.
- W4281696128 cites W1755645706 @default.
- W4281696128 cites W1969178306 @default.
- W4281696128 cites W1970016764 @default.
- W4281696128 cites W1972155984 @default.
- W4281696128 cites W1972401540 @default.
- W4281696128 cites W1973544766 @default.
- W4281696128 cites W1976280302 @default.
- W4281696128 cites W1980509775 @default.
- W4281696128 cites W1982489957 @default.
- W4281696128 cites W1998411920 @default.
- W4281696128 cites W2010452206 @default.
- W4281696128 cites W2013280216 @default.
- W4281696128 cites W2013714261 @default.
- W4281696128 cites W2030640565 @default.
- W4281696128 cites W2038699706 @default.
- W4281696128 cites W2052827499 @default.
- W4281696128 cites W2063492175 @default.
- W4281696128 cites W2068801152 @default.
- W4281696128 cites W2092167866 @default.
- W4281696128 cites W2128527026 @default.
- W4281696128 cites W2134967712 @default.
- W4281696128 cites W2211303178 @default.
- W4281696128 cites W2303390650 @default.
- W4281696128 cites W2324375397 @default.
- W4281696128 cites W2428539330 @default.
- W4281696128 cites W2471894478 @default.
- W4281696128 cites W2495327119 @default.
- W4281696128 cites W2514980738 @default.
- W4281696128 cites W2550980411 @default.
- W4281696128 cites W2555740579 @default.
- W4281696128 cites W2587747711 @default.
- W4281696128 cites W2594263910 @default.
- W4281696128 cites W2752819853 @default.
- W4281696128 cites W2755099980 @default.
- W4281696128 cites W2770580856 @default.
- W4281696128 cites W2781541645 @default.
- W4281696128 cites W2789686364 @default.
- W4281696128 cites W2791171052 @default.
- W4281696128 cites W2803940135 @default.
- W4281696128 cites W2884814715 @default.
- W4281696128 cites W2886660841 @default.
- W4281696128 cites W2888154174 @default.
- W4281696128 cites W2891885491 @default.
- W4281696128 cites W2893583353 @default.
- W4281696128 cites W2896531292 @default.
- W4281696128 cites W2898521203 @default.
- W4281696128 cites W2904456702 @default.
- W4281696128 cites W2909513240 @default.
- W4281696128 cites W2912682170 @default.
- W4281696128 cites W2914293025 @default.
- W4281696128 cites W2923395739 @default.
- W4281696128 cites W2936670974 @default.
- W4281696128 cites W2937886643 @default.
- W4281696128 cites W2965456113 @default.
- W4281696128 cites W2974575127 @default.
- W4281696128 cites W2976021733 @default.
- W4281696128 cites W2990080759 @default.
- W4281696128 cites W2990193948 @default.
- W4281696128 cites W2995837488 @default.
- W4281696128 cites W3010892062 @default.
- W4281696128 cites W3013784088 @default.
- W4281696128 cites W3015422576 @default.
- W4281696128 cites W3016437102 @default.
- W4281696128 cites W3021371728 @default.
- W4281696128 cites W3022523421 @default.
- W4281696128 cites W3040498589 @default.
- W4281696128 cites W3103094267 @default.
- W4281696128 cites W3110273846 @default.
- W4281696128 cites W3118604262 @default.
- W4281696128 cites W3128557726 @default.
- W4281696128 cites W3137482036 @default.
- W4281696128 cites W3155147229 @default.
- W4281696128 cites W3172423215 @default.
- W4281696128 cites W3173240284 @default.
- W4281696128 cites W3181602361 @default.
- W4281696128 cites W3188922434 @default.
- W4281696128 cites W3201087499 @default.
- W4281696128 cites W3204945049 @default.
- W4281696128 cites W4200280861 @default.
- W4281696128 cites W4200328701 @default.
- W4281696128 doi "https://doi.org/10.1021/acs.est.2c01850" @default.
- W4281696128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35658413" @default.
- W4281696128 hasPublicationYear "2022" @default.
- W4281696128 type Work @default.
- W4281696128 citedByCount "11" @default.
- W4281696128 countsByYear W42816961282023 @default.
- W4281696128 crossrefType "journal-article" @default.
- W4281696128 hasAuthorship W4281696128A5000385063 @default.