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- W4281698982 abstract "Diseases of the cardiovascular system keeps the lead among the main causes of invalidity, disability and mortality ofthe population. There is a steady increase in cardiovascular diseases, that is why the identification of new markers, that would allow calculating the risks of complications and associated pathological conditions, is one of the most important tasks of modern fundamental and applied medicine. The paper presents current information on the relationship between the qualitative and quantitative characteristics of mitochondrial DNA with the risk of organ failure. The reasons for the body's immune response to the mitochondrial DNA presence outside the cell are considered. The question of mitochondrial DNAs role in the pathogenesis of cardiovascular pathology and inflammatory processes is highlighted. Contradictory information about the change in the amount of freely circulating mitochondrial DNA during the development of organ failure was revealed. However, all authors agree that the number of mitochondrial DNA copies indicates disorders associated with the provision of vital functions of cells, organs and tissues. The study shows that the level of freely circulating mitochondrial DNA in blood plasma, which is currently used to predict the development of complications and mortality in a number of different diseases, is a promising nonspecific marker of cytolytic processes. A comprehensive study of cytological, biochemical and molecular biological indicators at various (especially at early) stages of organ failure development, as well as during the cardiovascular diseases establishment, will provide new important information about the cellular mechanisms of disease pathogenesis and will form the basis for the development of early diagnostic markers and new therapeutic schemes." @default.
- W4281698982 created "2022-06-13" @default.
- W4281698982 creator A5011290463 @default.
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- W4281698982 creator A5061984320 @default.
- W4281698982 date "2022-06-09" @default.
- W4281698982 modified "2023-09-26" @default.
- W4281698982 title "The role of mitochondrial DNA in the pathogenesis of cardiovascular diseases" @default.
- W4281698982 cites W1737281046 @default.
- W4281698982 cites W1783831484 @default.
- W4281698982 cites W1841582342 @default.
- W4281698982 cites W1921523468 @default.
- W4281698982 cites W1966276039 @default.
- W4281698982 cites W1987936501 @default.
- W4281698982 cites W1990171977 @default.
- W4281698982 cites W1990682984 @default.
- W4281698982 cites W1995588572 @default.
- W4281698982 cites W1998599956 @default.
- W4281698982 cites W2005853038 @default.
- W4281698982 cites W2008060326 @default.
- W4281698982 cites W2029821423 @default.
- W4281698982 cites W2033448006 @default.
- W4281698982 cites W2035461748 @default.
- W4281698982 cites W2042433863 @default.
- W4281698982 cites W2046418603 @default.
- W4281698982 cites W2050711948 @default.
- W4281698982 cites W2053870413 @default.
- W4281698982 cites W2091948085 @default.
- W4281698982 cites W2099610545 @default.
- W4281698982 cites W2112299930 @default.
- W4281698982 cites W2113729748 @default.
- W4281698982 cites W2122013546 @default.
- W4281698982 cites W2134219545 @default.
- W4281698982 cites W2149563173 @default.
- W4281698982 cites W2151775798 @default.
- W4281698982 cites W2187592006 @default.
- W4281698982 cites W2213528571 @default.
- W4281698982 cites W2280727461 @default.
- W4281698982 cites W2304872790 @default.
- W4281698982 cites W2363034775 @default.
- W4281698982 cites W2492891094 @default.
- W4281698982 cites W2521727246 @default.
- W4281698982 cites W2528470914 @default.
- W4281698982 cites W2536431346 @default.
- W4281698982 cites W2567252132 @default.
- W4281698982 cites W2588508001 @default.
- W4281698982 cites W2590525408 @default.
- W4281698982 cites W2591630426 @default.
- W4281698982 cites W2594681615 @default.
- W4281698982 cites W2607492645 @default.
- W4281698982 cites W2617613555 @default.
- W4281698982 cites W2638409322 @default.
- W4281698982 cites W2730107310 @default.
- W4281698982 cites W2736984475 @default.
- W4281698982 cites W2739940592 @default.
- W4281698982 cites W2748542265 @default.
- W4281698982 cites W2763236606 @default.
- W4281698982 cites W2775542957 @default.
- W4281698982 cites W2796765702 @default.
- W4281698982 cites W2883721603 @default.
- W4281698982 cites W2883766388 @default.
- W4281698982 cites W2891777339 @default.
- W4281698982 cites W2895614001 @default.
- W4281698982 cites W2909970879 @default.
- W4281698982 cites W2924420961 @default.
- W4281698982 cites W2943958582 @default.
- W4281698982 cites W2945740783 @default.
- W4281698982 cites W2946806111 @default.
- W4281698982 cites W2966817090 @default.
- W4281698982 cites W2967354508 @default.
- W4281698982 cites W2970782279 @default.
- W4281698982 cites W2973025652 @default.
- W4281698982 cites W2973265448 @default.
- W4281698982 cites W2975831328 @default.
- W4281698982 cites W2981256586 @default.
- W4281698982 cites W2990542525 @default.
- W4281698982 cites W2995218818 @default.
- W4281698982 cites W2996878821 @default.
- W4281698982 cites W3007801010 @default.
- W4281698982 cites W3010809227 @default.
- W4281698982 cites W3011551960 @default.
- W4281698982 cites W3012709102 @default.
- W4281698982 cites W3022929841 @default.
- W4281698982 cites W3031476910 @default.
- W4281698982 cites W3036253915 @default.
- W4281698982 cites W3083997048 @default.
- W4281698982 cites W3086680360 @default.
- W4281698982 cites W3087415224 @default.
- W4281698982 cites W3104345421 @default.
- W4281698982 cites W3113178943 @default.
- W4281698982 cites W3114558611 @default.
- W4281698982 cites W3152967454 @default.
- W4281698982 cites W3217049161 @default.
- W4281698982 cites W4232133836 @default.
- W4281698982 cites W4236925198 @default.
- W4281698982 cites W4237022625 @default.