FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281707023> ?p ?o ?g. }

• W4281707023 abstract "Increased glycolysis in tumor cells is frequently associated with drug resistance. Overexpression of glucose transporter-1 (GLUT1) promotes the Warburg effect and mediates chemoresistance in various cancers. Aberrant GLUT1 expression is considered as an essential early step in the development of endometrial cancer (EC). However, its role in EC glycolysis and chemoresistance and the upstream mechanisms underlying GLUT1 overexpression, remain undefined. Here, we demonstrated that GLUT1 was highly expressed in EC tissues and cell lines and that high GLUT1 expression was associated with poor prognosis in EC patients. Both gain-of-function and loss-of-function studies showed that GLUT1 increased EC cell proliferation, invasion, and glycolysis, while also making them resistant to paclitaxel. The long non-coding RNA TMPO-AS1 was found to be overexpressed in EC tissues and to be negatively associated with EC patient outcomes. RNA-immunoprecipitation and luciferase reporter assays confirmed that TMPO-AS1 elevated GLUT1 expression by directly binding to two critical tumor suppressor microRNAs (miR-140 and miR-143). Downregulation of TMPO-AS1 remarkably reduced EC cell proliferation, invasion, glycolysis, and paclitaxel resistance in EC cells. This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression. Thus, inhibiting TMPO-AS1 and GLUT1 may prove beneficial in overcoming glycolysis-induced paclitaxel resistance in patients with EC." @default.
• W4281707023 created "2022-06-13" @default.
• W4281707023 creator A5007473902 @default.
• W4281707023 creator A5013947994 @default.
• W4281707023 creator A5015909928 @default.
• W4281707023 creator A5026930111 @default.
• W4281707023 creator A5036752654 @default.
• W4281707023 creator A5059132370 @default.
• W4281707023 creator A5065485631 @default.
• W4281707023 creator A5083402329 @default.
• W4281707023 creator A5088284621 @default.
• W4281707023 date "2022-05-27" @default.
• W4281707023 modified "2023-09-26" @default.
• W4281707023 title "Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143" @default.
• W4281707023 cites W1176505728 @default.
• W4281707023 cites W1988092897 @default.
• W4281707023 cites W1993981670 @default.
• W4281707023 cites W2001537985 @default.
• W4281707023 cites W2021605685 @default.
• W4281707023 cites W2022101765 @default.
• W4281707023 cites W2037679360 @default.
• W4281707023 cites W2045133184 @default.
• W4281707023 cites W2066402608 @default.
• W4281707023 cites W2077435498 @default.
• W4281707023 cites W2080392221 @default.
• W4281707023 cites W2097375979 @default.
• W4281707023 cites W2116391873 @default.
• W4281707023 cites W2117692326 @default.
• W4281707023 cites W2129824771 @default.
• W4281707023 cites W2131247490 @default.
• W4281707023 cites W2134786121 @default.
• W4281707023 cites W2136575012 @default.
• W4281707023 cites W2137303371 @default.
• W4281707023 cites W2162868196 @default.
• W4281707023 cites W2170605129 @default.
• W4281707023 cites W2590374425 @default.
• W4281707023 cites W2590661425 @default.
• W4281707023 cites W2607721315 @default.
• W4281707023 cites W2753912669 @default.
• W4281707023 cites W2756438203 @default.
• W4281707023 cites W2799650544 @default.
• W4281707023 cites W2804218443 @default.
• W4281707023 cites W2883162731 @default.
• W4281707023 cites W2886324201 @default.
• W4281707023 cites W2889113684 @default.
• W4281707023 cites W2896124747 @default.
• W4281707023 cites W2907710771 @default.
• W4281707023 cites W2914376850 @default.
• W4281707023 cites W2917837889 @default.
• W4281707023 cites W2949072231 @default.
• W4281707023 cites W2959167276 @default.
• W4281707023 cites W2965722658 @default.
• W4281707023 cites W2972717944 @default.
• W4281707023 cites W2977130126 @default.
• W4281707023 cites W2979135307 @default.
• W4281707023 cites W2981009510 @default.
• W4281707023 cites W3003147351 @default.
• W4281707023 cites W3005804022 @default.
• W4281707023 cites W3033507040 @default.
• W4281707023 cites W3045177196 @default.
• W4281707023 cites W3048391824 @default.
• W4281707023 cites W3092400842 @default.
• W4281707023 cites W3129583292 @default.
• W4281707023 cites W3158686013 @default.
• W4281707023 cites W3175638837 @default.
• W4281707023 doi "https://doi.org/10.3389/fonc.2022.912935" @default.
• W4281707023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35712514" @default.
• W4281707023 hasPublicationYear "2022" @default.
• W4281707023 type Work @default.
• W4281707023 citedByCount "4" @default.
• W4281707023 countsByYear W42817070232022 @default.
• W4281707023 countsByYear W42817070232023 @default.
• W4281707023 crossrefType "journal-article" @default.
• W4281707023 hasAuthorship W4281707023A5007473902 @default.
• W4281707023 hasAuthorship W4281707023A5013947994 @default.
• W4281707023 hasAuthorship W4281707023A5015909928 @default.
• W4281707023 hasAuthorship W4281707023A5026930111 @default.
• W4281707023 hasAuthorship W4281707023A5036752654 @default.
• W4281707023 hasAuthorship W4281707023A5059132370 @default.
• W4281707023 hasAuthorship W4281707023A5065485631 @default.
• W4281707023 hasAuthorship W4281707023A5083402329 @default.
• W4281707023 hasAuthorship W4281707023A5088284621 @default.
• W4281707023 hasBestOaLocation W42817070231 @default.
• W4281707023 hasConcept C104317684 @default.
• W4281707023 hasConcept C121608353 @default.
• W4281707023 hasConcept C127561419 @default.
• W4281707023 hasConcept C134018914 @default.
• W4281707023 hasConcept C145059251 @default.
• W4281707023 hasConcept C161573976 @default.
• W4281707023 hasConcept C185592680 @default.
• W4281707023 hasConcept C20251656 @default.
• W4281707023 hasConcept C2777088508 @default.
• W4281707023 hasConcept C2777292972 @default.
• W4281707023 hasConcept C2777952866 @default.
• W4281707023 hasConcept C2779306644 @default.
• W4281707023 hasConcept C502942594 @default.
• W4281707023 hasConcept C54355233 @default.
• W4281707023 hasConcept C55493867 @default.
• W4281707023 hasConcept C62112901 @default.
• W4281707023 hasConcept C62231903 @default.

• next