FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281710020> ?p ?o ?g. }

• W4281710020 endingPage "113507" @default.
• W4281710020 startingPage "113507" @default.
• W4281710020 abstract "Exposure to fine particulate matter (PM2.5) is a prominent risk factor for cardiovascular aging in older adults and causes mild syndromes or other comorbidities in otherwise healthy older adults. Accordingly, a precise tool for PM2.5 exposure risk stratification is urgently needed. We aimed to address this need by comparing the performances of seven types of epigenetic age and chronological age to classify the effects of short-term PM2.5 exposure on blood pressure (BP), a typical clinical surrogate marker of cardiovascular aging. We conducted a panel study of the Chinese healthy adults aged 60–69 years through five monthly visits. Personal PM2.5 exposures were measured using wearable monitoring devices for three consecutive days, and DNA methylation was determined by the Illumina MethylationEPIC BeadChip using blood samples collected at each visit. Systolic BP, diastolic BP, mean arterial pressure and pulse pressure were measured by the electronic BP monitor. Linear mixed models with interaction terms between PM2.5 and different ages were used to assess their potential usefulness for stratification. DNAmPhenoAge, Skin & blood clock, DNAmGrimAge acceleration, and DunedinPoAm had significant modifying effects on the relationship between PM2.5 and BP. For instance, a 10-μg/m3 increase in the 72-h moving mean PM2.5 was significantly associated with 0.30% (95% CI: 0.10%, 0.51%) and −0.07% (95% CI: -0.32%, 0.18%) increases in systolic BP at higher and lower DNAmPhenoAge acceleration, respectively. Joint models further revealed that using a combination of epigenetic ages could more precisely stratify the effect of PM2.5 on BP. Our research indicates that epigenetic age may be a useful tool for evaluating the effect of short-term PM2.5 exposure on cardiovascular aging status." @default.
• W4281710020 created "2022-06-13" @default.
• W4281710020 creator A5002226367 @default.
• W4281710020 creator A5018955823 @default.
• W4281710020 creator A5047622041 @default.
• W4281710020 creator A5047625768 @default.
• W4281710020 creator A5063253432 @default.
• W4281710020 creator A5077185942 @default.
• W4281710020 creator A5078555011 @default.
• W4281710020 creator A5078962385 @default.
• W4281710020 date "2022-09-01" @default.
• W4281710020 modified "2023-10-16" @default.
• W4281710020 title "Epigenetic age stratifies the risk of blood pressure elevation related to short-term PM2.5 exposure in older adults" @default.
• W4281710020 cites W1917765704 @default.
• W4281710020 cites W1965951551 @default.
• W4281710020 cites W1974047233 @default.
• W4281710020 cites W2076093688 @default.
• W4281710020 cites W2121091193 @default.
• W4281710020 cites W2142194547 @default.
• W4281710020 cites W2169556367 @default.
• W4281710020 cites W2290343632 @default.
• W4281710020 cites W2416801689 @default.
• W4281710020 cites W2433197407 @default.
• W4281710020 cites W2529317472 @default.
• W4281710020 cites W2576832795 @default.
• W4281710020 cites W2592092784 @default.
• W4281710020 cites W2599190942 @default.
• W4281710020 cites W2612960000 @default.
• W4281710020 cites W2616483624 @default.
• W4281710020 cites W2775582148 @default.
• W4281710020 cites W2782561013 @default.
• W4281710020 cites W2784032956 @default.
• W4281710020 cites W2796559433 @default.
• W4281710020 cites W2803629855 @default.
• W4281710020 cites W2883262856 @default.
• W4281710020 cites W2885176254 @default.
• W4281710020 cites W2910005632 @default.
• W4281710020 cites W2912654909 @default.
• W4281710020 cites W2940776377 @default.
• W4281710020 cites W2949100461 @default.
• W4281710020 cites W2957796404 @default.
• W4281710020 cites W2966285784 @default.
• W4281710020 cites W2969382515 @default.
• W4281710020 cites W2971576504 @default.
• W4281710020 cites W2978124137 @default.
• W4281710020 cites W2978829449 @default.
• W4281710020 cites W2988993561 @default.
• W4281710020 cites W2990428470 @default.
• W4281710020 cites W2996871391 @default.
• W4281710020 cites W3000459089 @default.
• W4281710020 cites W3009276531 @default.
• W4281710020 cites W3014518127 @default.
• W4281710020 cites W3022131036 @default.
• W4281710020 cites W3022712724 @default.
• W4281710020 cites W3034057516 @default.
• W4281710020 cites W3042973453 @default.
• W4281710020 cites W3046908609 @default.
• W4281710020 cites W3086754494 @default.
• W4281710020 cites W3110984120 @default.
• W4281710020 cites W3112987067 @default.
• W4281710020 doi "https://doi.org/10.1016/j.envres.2022.113507" @default.
• W4281710020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35636465" @default.
• W4281710020 hasPublicationYear "2022" @default.
• W4281710020 type Work @default.
• W4281710020 citedByCount "3" @default.
• W4281710020 countsByYear W42817100202022 @default.
• W4281710020 crossrefType "journal-article" @default.
• W4281710020 hasAuthorship W4281710020A5002226367 @default.
• W4281710020 hasAuthorship W4281710020A5018955823 @default.
• W4281710020 hasAuthorship W4281710020A5047622041 @default.
• W4281710020 hasAuthorship W4281710020A5047625768 @default.
• W4281710020 hasAuthorship W4281710020A5063253432 @default.
• W4281710020 hasAuthorship W4281710020A5077185942 @default.
• W4281710020 hasAuthorship W4281710020A5078555011 @default.
• W4281710020 hasAuthorship W4281710020A5078962385 @default.
• W4281710020 hasConcept C104317684 @default.
• W4281710020 hasConcept C126322002 @default.
• W4281710020 hasConcept C144024400 @default.
• W4281710020 hasConcept C149923435 @default.
• W4281710020 hasConcept C164705383 @default.
• W4281710020 hasConcept C41091548 @default.
• W4281710020 hasConcept C54355233 @default.
• W4281710020 hasConcept C57900726 @default.
• W4281710020 hasConcept C71924100 @default.
• W4281710020 hasConcept C84393581 @default.
• W4281710020 hasConcept C86803240 @default.
• W4281710020 hasConceptScore W4281710020C104317684 @default.
• W4281710020 hasConceptScore W4281710020C126322002 @default.
• W4281710020 hasConceptScore W4281710020C144024400 @default.
• W4281710020 hasConceptScore W4281710020C149923435 @default.
• W4281710020 hasConceptScore W4281710020C164705383 @default.
• W4281710020 hasConceptScore W4281710020C41091548 @default.
• W4281710020 hasConceptScore W4281710020C54355233 @default.
• W4281710020 hasConceptScore W4281710020C57900726 @default.
• W4281710020 hasConceptScore W4281710020C71924100 @default.
• W4281710020 hasConceptScore W4281710020C84393581 @default.
• W4281710020 hasConceptScore W4281710020C86803240 @default.
• W4281710020 hasLocation W42817100201 @default.

• next