FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281710228> ?p ?o ?g. }

• W4281710228 endingPage "135256" @default.
• W4281710228 startingPage "135256" @default.
• W4281710228 abstract "Contamination of drinking water by carcinogen arsenic (As) is of worldwide concern as its exposure poses potential threat to human health. As such, it is important to understand the mechanisms associated with As-induced toxicity to humans. The Nrf2/Keap1 signal pathway is one of the most important defense mechanisms in cells to counter oxidative stress; however, limited information is available regarding its role in countering As-induced stress in model animal mouse. In this study, we assessed the responses of Nrf2/keap1 pathway in mice after chronic exposure to As at environmentally-relevant concentrations of 10-200 μg L-1 for 30 days via drinking water. Our results indicate that chronic As exposure had limited effect on mouse growth. However, As induced oxidative stress to mice as indicated by increased content of malondialdehyde (MDA; 52-90%), an index of lipid peroxidation. Further, arsenic exposure reduced the activity of superoxide dismutase (SOD; 14-18%), an indication of reduced anti-oxidative activity. Besides, arsenic exposure increased MnSOD mRNA transcription by 25-66%, and decreased the mRNA transcriptions of Cu/ZnSOD by 72-83% and metallothionein by 16-75%, a cysteine-rich protein involved in metal detoxification. To counter arsenic toxicity, the expression of transcription factor for Nrf2 and Keap1 was increased by 2.8-8.9 and 0.2-8.1 fold in mice. To effectively reduce As-induced oxidative stress, the Nrf2/Keap1 transcription factor upregulated several downstream anti-oxidative genes, including heme oxygenase-1 (0.9-2.5 fold), glutamate-cysteine ligase catalytic subunit (0.6-1.7 fold), and NADH quinone dehydrogenase 1 (2.1-4.8 fold). This study shows the importance of Nrf2/Keap1 signaling pathway and associated anti-oxidative enzymes in countering As-toxicity in mice, possibly having implication for human health." @default.
• W4281710228 created "2022-06-13" @default.
• W4281710228 creator A5001496905 @default.
• W4281710228 creator A5042293342 @default.
• W4281710228 creator A5087673120 @default.
• W4281710228 creator A5089755858 @default.
• W4281710228 date "2022-09-01" @default.
• W4281710228 modified "2023-10-03" @default.
• W4281710228 title "Nrf2/Keap1 pathway in countering arsenic-induced oxidative stress in mice after chronic exposure at environmentally-relevant concentrations" @default.
• W4281710228 cites W1166372783 @default.
• W4281710228 cites W1965891907 @default.
• W4281710228 cites W2007587878 @default.
• W4281710228 cites W2017816877 @default.
• W4281710228 cites W2023524211 @default.
• W4281710228 cites W2034355917 @default.
• W4281710228 cites W2037434205 @default.
• W4281710228 cites W2044194141 @default.
• W4281710228 cites W2046101078 @default.
• W4281710228 cites W2065945101 @default.
• W4281710228 cites W2081506009 @default.
• W4281710228 cites W2104109524 @default.
• W4281710228 cites W2136294249 @default.
• W4281710228 cites W2147090174 @default.
• W4281710228 cites W2161220011 @default.
• W4281710228 cites W2556758547 @default.
• W4281710228 cites W2743751242 @default.
• W4281710228 cites W2794139372 @default.
• W4281710228 cites W2805103431 @default.
• W4281710228 cites W2885837548 @default.
• W4281710228 cites W2912618603 @default.
• W4281710228 cites W2913636593 @default.
• W4281710228 cites W2949659667 @default.
• W4281710228 cites W2965095281 @default.
• W4281710228 cites W2969924053 @default.
• W4281710228 cites W3008407393 @default.
• W4281710228 cites W3015784228 @default.
• W4281710228 cites W3028066085 @default.
• W4281710228 cites W3041230423 @default.
• W4281710228 cites W3041300427 @default.
• W4281710228 cites W3070311419 @default.
• W4281710228 cites W3157461172 @default.
• W4281710228 cites W3169719498 @default.
• W4281710228 cites W3187405076 @default.
• W4281710228 cites W3206136667 @default.
• W4281710228 cites W3216459586 @default.
• W4281710228 doi "https://doi.org/10.1016/j.chemosphere.2022.135256" @default.
• W4281710228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35679981" @default.
• W4281710228 hasPublicationYear "2022" @default.
• W4281710228 type Work @default.
• W4281710228 citedByCount "9" @default.
• W4281710228 countsByYear W42817102282022 @default.
• W4281710228 countsByYear W42817102282023 @default.
• W4281710228 crossrefType "journal-article" @default.
• W4281710228 hasAuthorship W4281710228A5001496905 @default.
• W4281710228 hasAuthorship W4281710228A5042293342 @default.
• W4281710228 hasAuthorship W4281710228A5087673120 @default.
• W4281710228 hasAuthorship W4281710228A5089755858 @default.
• W4281710228 hasConcept C104317684 @default.
• W4281710228 hasConcept C172507514 @default.
• W4281710228 hasConcept C178790620 @default.
• W4281710228 hasConcept C181199279 @default.
• W4281710228 hasConcept C185592680 @default.
• W4281710228 hasConcept C20719415 @default.
• W4281710228 hasConcept C2775838275 @default.
• W4281710228 hasConcept C2776151105 @default.
• W4281710228 hasConcept C2776217839 @default.
• W4281710228 hasConcept C2776529522 @default.
• W4281710228 hasConcept C2778401633 @default.
• W4281710228 hasConcept C2778979269 @default.
• W4281710228 hasConcept C2779219270 @default.
• W4281710228 hasConcept C2779730776 @default.
• W4281710228 hasConcept C2780829032 @default.
• W4281710228 hasConcept C29730261 @default.
• W4281710228 hasConcept C502230775 @default.
• W4281710228 hasConcept C55493867 @default.
• W4281710228 hasConcept C86339819 @default.
• W4281710228 hasConceptScore W4281710228C104317684 @default.
• W4281710228 hasConceptScore W4281710228C172507514 @default.
• W4281710228 hasConceptScore W4281710228C178790620 @default.
• W4281710228 hasConceptScore W4281710228C181199279 @default.
• W4281710228 hasConceptScore W4281710228C185592680 @default.
• W4281710228 hasConceptScore W4281710228C20719415 @default.
• W4281710228 hasConceptScore W4281710228C2775838275 @default.
• W4281710228 hasConceptScore W4281710228C2776151105 @default.
• W4281710228 hasConceptScore W4281710228C2776217839 @default.
• W4281710228 hasConceptScore W4281710228C2776529522 @default.
• W4281710228 hasConceptScore W4281710228C2778401633 @default.
• W4281710228 hasConceptScore W4281710228C2778979269 @default.
• W4281710228 hasConceptScore W4281710228C2779219270 @default.
• W4281710228 hasConceptScore W4281710228C2779730776 @default.
• W4281710228 hasConceptScore W4281710228C2780829032 @default.
• W4281710228 hasConceptScore W4281710228C29730261 @default.
• W4281710228 hasConceptScore W4281710228C502230775 @default.
• W4281710228 hasConceptScore W4281710228C55493867 @default.
• W4281710228 hasConceptScore W4281710228C86339819 @default.
• W4281710228 hasFunder F4320321001 @default.
• W4281710228 hasFunder F4320335787 @default.
• W4281710228 hasLocation W42817102281 @default.

• next