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• W4281711496 abstract "Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide. However, the presence of the blood-labyrinth barrier (BLB) on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability, which restricts the entry of most drug compounds from the bloodstream into the inner ear tissue. Here, we report the finding of a novel receptor, low-density lipoprotein receptor-related protein 1 (LRP1), that is expressed on the BLB, as a potential target for shuttling therapeutics across this barrier. As a proof-of-concept, we developed an LRP1-binding peptide, IETP2, and covalently conjugated a series of model small-molecule compounds to it, including potential drugs and imaging agents. All compounds were successfully delivered into the inner ear and inner ear lymph, indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the BLB. The discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders." @default.
• W4281711496 created "2022-06-13" @default.
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• W4281711496 date "2022-06-10" @default.
• W4281711496 modified "2023-09-26" @default.
• W4281711496 title "LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)" @default.
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• W4281711496 doi "https://doi.org/10.1038/s41392-022-00995-z" @default.
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