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- W4281712814 endingPage "2735" @default.
- W4281712814 startingPage "2735" @default.
- W4281712814 abstract "Cancer is a leading cause of death worldwide. If left untreated, tumors tend to grow and spread uncontrolled until the patient dies. To support this growth, cancer cells need large amounts of nutrients and growth factors that are supplied and distributed to the tumor tissue by the vascular system. The aberrant tumor vasculature shows deep morphological, molecular, and metabolic differences compared to the blood vessels belonging to the non-malignant tissues (also referred as normal). A better understanding of the metabolic mechanisms driving the differences between normal and tumor vasculature will allow the designing of new drugs with a higher specificity of action and fewer side effects to target tumors and improve a patient's life expectancy. In this review, we aim to summarize the main features of tumor endothelial cells (TECs) and shed light on the critical metabolic pathways that characterize these cells. A better understanding of such mechanisms will help to design innovative therapeutic strategies in healthy and diseased angiogenesis." @default.
- W4281712814 created "2022-06-13" @default.
- W4281712814 creator A5000420799 @default.
- W4281712814 creator A5011103445 @default.
- W4281712814 creator A5048243012 @default.
- W4281712814 date "2022-05-31" @default.
- W4281712814 modified "2023-10-14" @default.
- W4281712814 title "Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells" @default.
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