FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281713938> ?p ?o ?g. }

• W4281713938 abstract "Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disorder caused by abnormal extracellular matrix deposition, which results in increasing dyspnea and loss of pulmonary function. Pirfenidone (PFD) has antifibrotic properties that have been approved by the US FDA for the treatment of IPF. Pirfenidone is currently delivered orally, which has drawbacks like reduced bioavailability in the presence of food, gastrointestinal (dyspepsia and anorexia), and dermatological (photosensitivity) side-effects, large amount of dose, and elimination half-life of 2.4 h. This study aimed was to prepare inhalable powders containing PFD-loaded chitosan nanoparticles for sustained delivery of the drug to the lung. Result The quasi-solvent diffusion method was used with optimized 100 mg PFD and 100 mg chitosan (CS). An in-vitro drug release research found that increasing the amount of chitosan reduced the rate of drug release from nanoparticles. Entrapment of PFD into chitosan nanoparticles decreased with the increased concentration of stabilizer concentration. All batches produced nanoparticles with a spherical morphology confirmed by SEM and sizes ranging from 239.3 ± 1.8 to 928.7 ± 4.6 nm. The optimized nanoparticles exhibited a mean particle size of 467.33 ± 7.8 nm with a polydispersity index of 0.127 ± 0.022, zeta potential of + 34.8 ± 1.6 mV, % entrapment efficiency (39.45 ± 4.63%), % drug release after 12 h (94.78 ± 2.88%), and in-vitro deposition (81.49%). Results showed that the obtained powders had different aerosolization properties. The particle size of nanoparticles reduced, and the process yield, extra-fine particle fraction, geometric standard diameter, and fine particle fraction increased significantly. Stability study showed, there are no aggregation observed and stable for six month study. Conclusion Prepared pirfenidone-loaded chitosan nanoparticles can be result of 6 months of stability studies that give details that there was no significant aggregation of PFD-loaded CS NPs and the spherical shape particle with smooth surface as per SEM studies. Hence, PFD-loaded CS NPs can be a suitable alternative to the currently available therapy. Graphical abstract" @default.
• W4281713938 created "2022-06-13" @default.
• W4281713938 creator A5018052910 @default.
• W4281713938 creator A5062787035 @default.
• W4281713938 date "2022-06-03" @default.
• W4281713938 modified "2023-09-30" @default.
• W4281713938 title "Preparation and evaluation of pirfenidone loaded chitosan nanoparticles pulmonary delivery for idiopathic pulmonary fibrosis" @default.
• W4281713938 cites W1971645600 @default.
• W4281713938 cites W1977002306 @default.
• W4281713938 cites W1993559550 @default.
• W4281713938 cites W1998274991 @default.
• W4281713938 cites W2015192101 @default.
• W4281713938 cites W2024948107 @default.
• W4281713938 cites W2026969625 @default.
• W4281713938 cites W2040661857 @default.
• W4281713938 cites W2042006898 @default.
• W4281713938 cites W2044486914 @default.
• W4281713938 cites W2046501504 @default.
• W4281713938 cites W2065167977 @default.
• W4281713938 cites W2075187717 @default.
• W4281713938 cites W2079745748 @default.
• W4281713938 cites W2100059970 @default.
• W4281713938 cites W2130100308 @default.
• W4281713938 cites W2157869208 @default.
• W4281713938 cites W2213430347 @default.
• W4281713938 cites W2330282224 @default.
• W4281713938 cites W2550523848 @default.
• W4281713938 cites W2552601893 @default.
• W4281713938 cites W2599075603 @default.
• W4281713938 cites W2601160133 @default.
• W4281713938 cites W2740434506 @default.
• W4281713938 cites W2792569575 @default.
• W4281713938 cites W2795056256 @default.
• W4281713938 cites W2885862567 @default.
• W4281713938 cites W2946252275 @default.
• W4281713938 cites W2948621389 @default.
• W4281713938 cites W2955019060 @default.
• W4281713938 cites W2979578978 @default.
• W4281713938 cites W2979916718 @default.
• W4281713938 cites W2988066064 @default.
• W4281713938 cites W3010294138 @default.
• W4281713938 cites W3023820431 @default.
• W4281713938 cites W3024787030 @default.
• W4281713938 cites W3088343001 @default.
• W4281713938 cites W3125148818 @default.
• W4281713938 cites W3130038318 @default.
• W4281713938 cites W3197634468 @default.
• W4281713938 cites W4296612182 @default.
• W4281713938 doi "https://doi.org/10.1186/s43094-022-00419-3" @default.
• W4281713938 hasPublicationYear "2022" @default.
• W4281713938 type Work @default.
• W4281713938 citedByCount "1" @default.
• W4281713938 countsByYear W42817139382023 @default.
• W4281713938 crossrefType "journal-article" @default.
• W4281713938 hasAuthorship W4281713938A5018052910 @default.
• W4281713938 hasAuthorship W4281713938A5062787035 @default.
• W4281713938 hasBestOaLocation W42817139381 @default.
• W4281713938 hasConcept C11432220 @default.
• W4281713938 hasConcept C126322002 @default.
• W4281713938 hasConcept C147789679 @default.
• W4281713938 hasConcept C155672457 @default.
• W4281713938 hasConcept C171250308 @default.
• W4281713938 hasConcept C178790620 @default.
• W4281713938 hasConcept C181389837 @default.
• W4281713938 hasConcept C185592680 @default.
• W4281713938 hasConcept C187530423 @default.
• W4281713938 hasConcept C188027245 @default.
• W4281713938 hasConcept C192562407 @default.
• W4281713938 hasConcept C2776954882 @default.
• W4281713938 hasConcept C2777714996 @default.
• W4281713938 hasConcept C2778341716 @default.
• W4281713938 hasConcept C2779732960 @default.
• W4281713938 hasConcept C2779832356 @default.
• W4281713938 hasConcept C42219234 @default.
• W4281713938 hasConcept C71924100 @default.
• W4281713938 hasConcept C82085835 @default.
• W4281713938 hasConcept C98274493 @default.
• W4281713938 hasConceptScore W4281713938C11432220 @default.
• W4281713938 hasConceptScore W4281713938C126322002 @default.
• W4281713938 hasConceptScore W4281713938C147789679 @default.
• W4281713938 hasConceptScore W4281713938C155672457 @default.
• W4281713938 hasConceptScore W4281713938C171250308 @default.
• W4281713938 hasConceptScore W4281713938C178790620 @default.
• W4281713938 hasConceptScore W4281713938C181389837 @default.
• W4281713938 hasConceptScore W4281713938C185592680 @default.
• W4281713938 hasConceptScore W4281713938C187530423 @default.
• W4281713938 hasConceptScore W4281713938C188027245 @default.
• W4281713938 hasConceptScore W4281713938C192562407 @default.
• W4281713938 hasConceptScore W4281713938C2776954882 @default.
• W4281713938 hasConceptScore W4281713938C2777714996 @default.
• W4281713938 hasConceptScore W4281713938C2778341716 @default.
• W4281713938 hasConceptScore W4281713938C2779732960 @default.
• W4281713938 hasConceptScore W4281713938C2779832356 @default.
• W4281713938 hasConceptScore W4281713938C42219234 @default.
• W4281713938 hasConceptScore W4281713938C71924100 @default.
• W4281713938 hasConceptScore W4281713938C82085835 @default.
• W4281713938 hasConceptScore W4281713938C98274493 @default.
• W4281713938 hasIssue "1" @default.
• W4281713938 hasLocation W42817139381 @default.
• W4281713938 hasOpenAccess W4281713938 @default.

• next