FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281715523> ?p ?o ?g. }

• W4281715523 endingPage "1084" @default.
• W4281715523 startingPage "1077" @default.
• W4281715523 abstract "Precision medicine refers to treatments that are targeted to an individual's unique characteristics. Precision medicine for neurodevelopmental disorders (such as cerebral palsy, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, Tourette syndrome, and autism spectrum disorder) in children has predominantly focused on advances in genomic sequencing technologies to increase our ability to identify single gene mutations, diagnose a multitude of rare neurodevelopmental disorders, and gain insights into pathogenesis. Although targeting specific gene variants with high penetrance will help some children with rare disease, this approach will not help most children with neurodevelopmental disorders. A 'pathway' driven approach targeting the cumulative influence of psychosocial, epigenetic, or cellular factors is likely to be more effective. To optimize the therapeutic potential of precision medicine, we present a biopsychosocial integrated framework to examine the 'gene-environment neuroscience interaction'. Such an approach would be supported through harnessing the power of big data, transdiagnostic assessment, impact and implementation evaluation, and a bench-to-bedside scientific discovery agenda with ongoing clinician and patient engagement. WHAT THIS PAPER ADDS: Precision medicine has predominantly focused on genetic risk factors. The impact of environmental risk factors, particularly inflammatory, metabolic, and psychosocial risks, is understudied. A holistic biopsychosocial model of neurodevelopmental disorder causal pathways is presented. The model will provide precision medicine across the full spectrum of neurodevelopmental disorders." @default.
• W4281715523 created "2022-06-13" @default.
• W4281715523 creator A5001739615 @default.
• W4281715523 creator A5018878408 @default.
• W4281715523 creator A5023485346 @default.
• W4281715523 creator A5023877721 @default.
• W4281715523 creator A5030059210 @default.
• W4281715523 creator A5055131103 @default.
• W4281715523 creator A5056193115 @default.
• W4281715523 creator A5062747031 @default.
• W4281715523 creator A5064242384 @default.
• W4281715523 creator A5085556623 @default.
• W4281715523 date "2022-06-06" @default.
• W4281715523 modified "2023-10-17" @default.
• W4281715523 title "Delivering paediatric precision medicine: Genomic and environmental considerations along the causal pathway of childhood neurodevelopmental disorders" @default.
• W4281715523 cites W1933950922 @default.
• W4281715523 cites W1944223970 @default.
• W4281715523 cites W1976980527 @default.
• W4281715523 cites W2050336499 @default.
• W4281715523 cites W2059028608 @default.
• W4281715523 cites W2100407705 @default.
• W4281715523 cites W2128782957 @default.
• W4281715523 cites W2371597434 @default.
• W4281715523 cites W2416060637 @default.
• W4281715523 cites W2515897135 @default.
• W4281715523 cites W2769247819 @default.
• W4281715523 cites W2775091641 @default.
• W4281715523 cites W2889500216 @default.
• W4281715523 cites W2890723424 @default.
• W4281715523 cites W2891594781 @default.
• W4281715523 cites W2921481306 @default.
• W4281715523 cites W2938665791 @default.
• W4281715523 cites W2976851556 @default.
• W4281715523 cites W2984989497 @default.
• W4281715523 cites W2991851654 @default.
• W4281715523 cites W3012319565 @default.
• W4281715523 cites W3033056129 @default.
• W4281715523 cites W3087820214 @default.
• W4281715523 cites W3090838011 @default.
• W4281715523 cites W3123281643 @default.
• W4281715523 cites W3129866927 @default.
• W4281715523 cites W3136154278 @default.
• W4281715523 cites W3183683175 @default.
• W4281715523 cites W3187226810 @default.
• W4281715523 cites W3216629691 @default.
• W4281715523 cites W4281715523 @default.
• W4281715523 doi "https://doi.org/10.1111/dmcn.15289" @default.
• W4281715523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35661141" @default.
• W4281715523 hasPublicationYear "2022" @default.
• W4281715523 type Work @default.
• W4281715523 citedByCount "4" @default.
• W4281715523 countsByYear W42817155232022 @default.
• W4281715523 countsByYear W42817155232023 @default.
• W4281715523 crossrefType "journal-article" @default.
• W4281715523 hasAuthorship W4281715523A5001739615 @default.
• W4281715523 hasAuthorship W4281715523A5018878408 @default.
• W4281715523 hasAuthorship W4281715523A5023485346 @default.
• W4281715523 hasAuthorship W4281715523A5023877721 @default.
• W4281715523 hasAuthorship W4281715523A5030059210 @default.
• W4281715523 hasAuthorship W4281715523A5055131103 @default.
• W4281715523 hasAuthorship W4281715523A5056193115 @default.
• W4281715523 hasAuthorship W4281715523A5062747031 @default.
• W4281715523 hasAuthorship W4281715523A5064242384 @default.
• W4281715523 hasAuthorship W4281715523A5085556623 @default.
• W4281715523 hasBestOaLocation W42817155232 @default.
• W4281715523 hasConcept C118552586 @default.
• W4281715523 hasConcept C137886200 @default.
• W4281715523 hasConcept C142724271 @default.
• W4281715523 hasConcept C150966472 @default.
• W4281715523 hasConcept C15744967 @default.
• W4281715523 hasConcept C163763905 @default.
• W4281715523 hasConcept C169760540 @default.
• W4281715523 hasConcept C205778803 @default.
• W4281715523 hasConcept C2778538070 @default.
• W4281715523 hasConcept C2779388368 @default.
• W4281715523 hasConcept C32220436 @default.
• W4281715523 hasConcept C60644358 @default.
• W4281715523 hasConcept C71924100 @default.
• W4281715523 hasConcept C86803240 @default.
• W4281715523 hasConceptScore W4281715523C118552586 @default.
• W4281715523 hasConceptScore W4281715523C137886200 @default.
• W4281715523 hasConceptScore W4281715523C142724271 @default.
• W4281715523 hasConceptScore W4281715523C150966472 @default.
• W4281715523 hasConceptScore W4281715523C15744967 @default.
• W4281715523 hasConceptScore W4281715523C163763905 @default.
• W4281715523 hasConceptScore W4281715523C169760540 @default.
• W4281715523 hasConceptScore W4281715523C205778803 @default.
• W4281715523 hasConceptScore W4281715523C2778538070 @default.
• W4281715523 hasConceptScore W4281715523C2779388368 @default.
• W4281715523 hasConceptScore W4281715523C32220436 @default.
• W4281715523 hasConceptScore W4281715523C60644358 @default.
• W4281715523 hasConceptScore W4281715523C71924100 @default.
• W4281715523 hasConceptScore W4281715523C86803240 @default.
• W4281715523 hasFunder F4320321105 @default.
• W4281715523 hasFunder F4320323274 @default.
• W4281715523 hasFunder F4320334705 @default.
• W4281715523 hasIssue "9" @default.
• W4281715523 hasLocation W42817155231 @default.

• next