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- W4281715972 abstract "Stimulation of the body's immune system toward tumor cells is now well recognized as a promising strategy in cancer therapy. Just behind cell therapy and monoclonal antibodies, small molecule-based strategies are receiving growing attention as alternatives to direct immune response against tumor cells. However, the development of small-molecule approaches to modulate the balance between stimulatory immune factors and suppressive factors in a targeted way remains a challenge. Here, we report the cell surface functionalization of LS174T cancer cells with an abiotic hapten to recruit antibodies to the cell surface. Metabolic glycoengineering followed by covalent reaction with the hapten results in antibody recognition of the target cells. Microscopy and flow cytometry studies provide compelling evidence that metabolic glycoengineering and small molecule stimulators can be combined to direct antibody recognition." @default.
- W4281715972 created "2022-06-13" @default.
- W4281715972 creator A5014113644 @default.
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- W4281715972 date "2022-06-20" @default.
- W4281715972 modified "2023-09-27" @default.
- W4281715972 title "Antibody Recognition of Cancer Cells via Glycan Surface Engineering" @default.
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- W4281715972 doi "https://doi.org/10.1002/cbic.202200125" @default.
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