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- W4281733293 abstract "Abstract Background Current guidelines consider T-DM1 the standard 2 nd line therapy for HER2 positive metastatic breast cancer (MBC) patients following trastuzumab (T) + pertuzumab (P) and taxane 1 st line treatment. Despite this, there are no prospective studies supporting this sequence. Methods We performed a meta-analysis using real world data to determine the efficacy of T-DM1 after 1 st line TP in HER2 positive MBC patients. We used a random-effect model to find differences in the rate of 1-year progression free survival (PFS) between TP pre-treated population and the EMILIA phase III pivotal trial. Results Seven studies were eligible. The meta-analysis showed a combined 1-year PFS risk difference for T-DM1 efficacy after TP in 2 nd or more lines of -0.122, with lower and upper limits of -0.253 and 0.010, respectively ( p = 0.07), with low heterogeneity among studies (I 2 0.01%, p = 0.836). Considering the four studies on T-DM1 in 2 nd line setting, 1-year PFS risk was -0.034 (95% CI -0.207 – 0,139; p = 0.701) (I 2 0.01%, p = 0.91). Conclusion Overall, the efficacy of T-DM1 after TP seems to be similar to that previously reported in the EMILIA trial. In the second line setting, data are not mature enough to confirm T-DM1 efficacy in TP pre-treated population." @default.
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- W4281733293 date "2022-06-07" @default.
- W4281733293 modified "2023-10-14" @default.
- W4281733293 title "T-DM1 efficacy in trastuzumab-pertuzumab pre-treated HER2 positive metastatic breast cancer patients: a meta-analysis" @default.
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- W4281733293 doi "https://doi.org/10.1186/s12885-022-09556-7" @default.
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