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- W4281735269 abstract "Abstract Papillary thyroid carcinoma (PTC) is the most common subtype in thyroid cancers. In this study, altered co-expression analysis was performed to identify molecular signatures that could take a role in disease pathogenesis via comparative analysis of correlation of gene expression between different states (i.e: PTC and non-tumor tissues). As a result, putative systems biomarkers in PTC were determined. Moreover, resultant genes were found to have significantly high performance in distinguishing tumor and non-tumor samples and were identified as prognostic genes. Especially, several molecular signatures such as EPHA3, LYVE1, and TACR2 as receptors, TFCP2L1, MEOX2, and ZFPM2 as transcription factors (TFs), AKR1C2, AOX1, GALNT7 QPCT, GALE, and RPS6KA5 as enzymes came into prominence. The presented genes here will be a crucial resource for new prognostic and therapeutic strategies for PTC." @default.
- W4281735269 created "2022-06-13" @default.
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- W4281735269 date "2022-06-06" @default.
- W4281735269 modified "2023-10-16" @default.
- W4281735269 title "Bioinformatics prediction and analysis of co-altered genes as prognostic targets for papillary thyroid carcinoma" @default.
- W4281735269 doi "https://doi.org/10.21203/rs.3.rs-1697373/v1" @default.
- W4281735269 hasPublicationYear "2022" @default.
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