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- W4281736013 abstract "Abstract Background Obesity is a factor associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in patients with asthma is not fully understood. Methods A total of 193 patients with asthma and 2,159 patients without asthma who visited Saga University Hospital were investigated retrospectively. Obesity was defined as a body mass index (BMI) greater than 25 kg/m 2 . Pulmonary functions including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV 1 ) were compared between patients with asthma and those without asthma, focusing especially on obesity. Results %FVC, FEV 1 , and %FEV 1 , but not FVC were significantly lower in patients with asthma than in those without asthma (p < 0.01, < 0.01, < 0.01, 0.25, respectively). In patients with asthma, FVC, %FVC, FEV 1 , and %FEV 1 were significantly lower in patients with obesity than in those without obesity (all p < 0.01). In addition, BMI was negatively correlated with FEV 1 (r = − 0.21, p = 0.003) and FVC (r = -0.15, p = 0.04). On multivariate analysis in patients with asthma, FVC (β [95% confidence interval] 0.11 [0.01–0.02], p = 0.02) and FEV 1 (0.13 [0.05–0.21], p < 0.01) were still significant between patients with obesity versus patients without obesity. However, those obesity-associated differences were not observed in patients without asthma. Conclusion Obesity reduces pulmonary function including FVC and FEV 1 in patients with asthma but not in those without asthma." @default.
- W4281736013 created "2022-06-13" @default.
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- W4281736013 date "2022-06-06" @default.
- W4281736013 modified "2023-10-16" @default.
- W4281736013 title "Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma" @default.
- W4281736013 doi "https://doi.org/10.21203/rs.3.rs-1657224/v2" @default.
- W4281736013 hasPublicationYear "2022" @default.
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