FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281738208> ?p ?o ?g. }

• W4281738208 endingPage "101649" @default.
• W4281738208 startingPage "101649" @default.
• W4281738208 abstract "Currently, no pharmacotherapy is routinely used for obstructive sleep apnea (OSA). Recently, combined noradrenergic plus antimuscarinic agents have been evaluated for the treatment of OSA in several trials. This systematic review and meta-analysis following PRISMA guidelines investigated the efficacy and safety of this combination drug regimen for the treatment of OSA. Seven databases were systematically screened for randomized controlled trials (RCTs) studying combined noradrenergic plus antimuscarinic agents for OSA to April 2022. Nine RCTs were identified for systematic review and five for meta-analysis. There were significant differences between OSA patients taking noradrenergic plus antimuscarinic agents and placebo with respect to sleep apnea-hypopnea index [mean difference (MD) −11.27 events/h, 95%CI (−21.69, −0.84) events/h; P = 0.03]; nadir oxygen saturation [MD 5.06%, 95% CI (2.57, 7.55)%; P < 0.0001], and arousal index [MD -8.17 events/h, 95% CI (−15.01, −1.33) events/h; P = 0.02] but not sleep efficiency. Our systematic review revealed that drug therapy modestly improved loop gain and upper airway collapsibility but decreased arousal threshold. A combination of noradrenergic and antimuscarinic agents administered orally before bedtime on one night significantly reduced OSA severity and improved OSA upper airway function. The long-term efficacy and safety of drug combinations in OSA patients now require further study." @default.
• W4281738208 created "2022-06-13" @default.
• W4281738208 creator A5012858137 @default.
• W4281738208 creator A5016523976 @default.
• W4281738208 creator A5037636921 @default.
• W4281738208 creator A5074708643 @default.
• W4281738208 creator A5083141797 @default.
• W4281738208 date "2022-08-01" @default.
• W4281738208 modified "2023-10-15" @default.
• W4281738208 title "Combined noradrenergic plus antimuscarinic agents for obstructive sleep apnea - A systematic review and meta-analysis of randomized controlled trials" @default.
• W4281738208 cites W1596635370 @default.
• W4281738208 cites W1965987914 @default.
• W4281738208 cites W2007788870 @default.
• W4281738208 cites W2014272362 @default.
• W4281738208 cites W2023663028 @default.
• W4281738208 cites W2042592767 @default.
• W4281738208 cites W2046019168 @default.
• W4281738208 cites W2049813113 @default.
• W4281738208 cites W2061907861 @default.
• W4281738208 cites W2103147133 @default.
• W4281738208 cites W2103886737 @default.
• W4281738208 cites W2148687419 @default.
• W4281738208 cites W2172233351 @default.
• W4281738208 cites W2331044984 @default.
• W4281738208 cites W2471195096 @default.
• W4281738208 cites W2509258559 @default.
• W4281738208 cites W2576440140 @default.
• W4281738208 cites W2592857683 @default.
• W4281738208 cites W2618399899 @default.
• W4281738208 cites W2801441055 @default.
• W4281738208 cites W2801923522 @default.
• W4281738208 cites W2900097455 @default.
• W4281738208 cites W2907548584 @default.
• W4281738208 cites W2936513876 @default.
• W4281738208 cites W2988012158 @default.
• W4281738208 cites W3003238214 @default.
• W4281738208 cites W3004160311 @default.
• W4281738208 cites W3015537361 @default.
• W4281738208 cites W3123254561 @default.
• W4281738208 cites W3135993931 @default.
• W4281738208 cites W3136850302 @default.
• W4281738208 cites W3174498277 @default.
• W4281738208 cites W3174792967 @default.
• W4281738208 cites W3200404873 @default.
• W4281738208 cites W3203264360 @default.
• W4281738208 cites W3205385609 @default.
• W4281738208 cites W4294215472 @default.
• W4281738208 doi "https://doi.org/10.1016/j.smrv.2022.101649" @default.
• W4281738208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35709641" @default.
• W4281738208 hasPublicationYear "2022" @default.
• W4281738208 type Work @default.
• W4281738208 citedByCount "6" @default.
• W4281738208 countsByYear W42817382082022 @default.
• W4281738208 countsByYear W42817382082023 @default.
• W4281738208 crossrefType "journal-article" @default.
• W4281738208 hasAuthorship W4281738208A5012858137 @default.
• W4281738208 hasAuthorship W4281738208A5016523976 @default.
• W4281738208 hasAuthorship W4281738208A5037636921 @default.
• W4281738208 hasAuthorship W4281738208A5074708643 @default.
• W4281738208 hasAuthorship W4281738208A5083141797 @default.
• W4281738208 hasBestOaLocation W42817382081 @default.
• W4281738208 hasConcept C126322002 @default.
• W4281738208 hasConcept C142724271 @default.
• W4281738208 hasConcept C168563851 @default.
• W4281738208 hasConcept C204787440 @default.
• W4281738208 hasConcept C27081682 @default.
• W4281738208 hasConcept C2776006263 @default.
• W4281738208 hasConcept C2776377968 @default.
• W4281738208 hasConcept C2777935920 @default.
• W4281738208 hasConcept C2778205975 @default.
• W4281738208 hasConcept C2779547634 @default.
• W4281738208 hasConcept C2781326671 @default.
• W4281738208 hasConcept C42219234 @default.
• W4281738208 hasConcept C71924100 @default.
• W4281738208 hasConcept C95190672 @default.
• W4281738208 hasConceptScore W4281738208C126322002 @default.
• W4281738208 hasConceptScore W4281738208C142724271 @default.
• W4281738208 hasConceptScore W4281738208C168563851 @default.
• W4281738208 hasConceptScore W4281738208C204787440 @default.
• W4281738208 hasConceptScore W4281738208C27081682 @default.
• W4281738208 hasConceptScore W4281738208C2776006263 @default.
• W4281738208 hasConceptScore W4281738208C2776377968 @default.
• W4281738208 hasConceptScore W4281738208C2777935920 @default.
• W4281738208 hasConceptScore W4281738208C2778205975 @default.
• W4281738208 hasConceptScore W4281738208C2779547634 @default.
• W4281738208 hasConceptScore W4281738208C2781326671 @default.
• W4281738208 hasConceptScore W4281738208C42219234 @default.
• W4281738208 hasConceptScore W4281738208C71924100 @default.
• W4281738208 hasConceptScore W4281738208C95190672 @default.
• W4281738208 hasFunder F4320321001 @default.
• W4281738208 hasLocation W42817382081 @default.
• W4281738208 hasLocation W42817382082 @default.
• W4281738208 hasOpenAccess W4281738208 @default.
• W4281738208 hasPrimaryLocation W42817382081 @default.
• W4281738208 hasRelatedWork W1998887778 @default.
• W4281738208 hasRelatedWork W2015198114 @default.
• W4281738208 hasRelatedWork W2075847911 @default.
• W4281738208 hasRelatedWork W2113982368 @default.

• next