FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281738209> ?p ?o ?g. }

• W4281738209 abstract "Although levofloxacin has been used for the last 25 years, there are limited pharmacokinetic data to guide levofloxacin dosing in adult patients. This study aimed to develop a population pharmacokinetic model of levofloxacin for adult hospitalized patients and define dosing regimens that attain pharmacokinetic/pharmacodynamic target associated with maximum effectiveness. Blood samples were drawn from 26 patients during one dosing interval. Population pharmacokinetic modelling and dosign simulations were performed using Pmetrics®. Pathogen minimum inhibition concentration (MIC) distribution data from the European Committee on Antimicrobial Susceptibility Testing database was used to analyse fractional target attainment (FTA). A two-compartment model adequately described the data. The final model included estimated glomerular filtration rate (eGFR) to describe clearance. The population estimate for clearance was 1.12 L/h, while the volume of distribution in the central compartment and peripheral compartments were 27.6 L and 28.2 L, respectively. Our simulation demonstrated that an area under free concentration-time curve to MIC ≥ 80 was hardly achieved for pathogens with MIC ≥ 1 mg/L. Low FTA against Pseudomonas aeruginosa and Streptococcus pneumoniae were observed for patients with higher eGFR (≥ 80 mL/min/1.73m2). A daily levofloxacin dose of 1000 mg is suggested to maximise the likelihood of efficacy for adult patients." @default.
• W4281738209 created "2022-06-13" @default.
• W4281738209 creator A5005119582 @default.
• W4281738209 creator A5023205278 @default.
• W4281738209 creator A5023993805 @default.
• W4281738209 creator A5036244788 @default.
• W4281738209 creator A5043218702 @default.
• W4281738209 creator A5046828437 @default.
• W4281738209 creator A5071820901 @default.
• W4281738209 creator A5073546855 @default.
• W4281738209 creator A5084952424 @default.
• W4281738209 date "2022-05-27" @default.
• W4281738209 modified "2023-10-15" @default.
• W4281738209 title "Population pharmacokinetics and dose optimization of intravenous levofloxacin in hospitalized adult patients" @default.
• W4281738209 cites W1459641852 @default.
• W4281738209 cites W1562498729 @default.
• W4281738209 cites W1732153887 @default.
• W4281738209 cites W1921056904 @default.
• W4281738209 cites W1983411303 @default.
• W4281738209 cites W2015821083 @default.
• W4281738209 cites W2021298363 @default.
• W4281738209 cites W2029235612 @default.
• W4281738209 cites W2070617816 @default.
• W4281738209 cites W2090528602 @default.
• W4281738209 cites W2096657485 @default.
• W4281738209 cites W2098462629 @default.
• W4281738209 cites W2099125976 @default.
• W4281738209 cites W2118138801 @default.
• W4281738209 cites W2122563473 @default.
• W4281738209 cites W2155965977 @default.
• W4281738209 cites W2196730119 @default.
• W4281738209 cites W2333696289 @default.
• W4281738209 cites W2470144076 @default.
• W4281738209 cites W2473016454 @default.
• W4281738209 cites W2561358501 @default.
• W4281738209 cites W2607031541 @default.
• W4281738209 cites W2615010047 @default.
• W4281738209 cites W2889562406 @default.
• W4281738209 cites W2912511769 @default.
• W4281738209 cites W2977322360 @default.
• W4281738209 cites W3022327571 @default.
• W4281738209 doi "https://doi.org/10.1038/s41598-022-12627-1" @default.
• W4281738209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35624222" @default.
• W4281738209 hasPublicationYear "2022" @default.
• W4281738209 type Work @default.
• W4281738209 citedByCount "2" @default.
• W4281738209 countsByYear W42817382092022 @default.
• W4281738209 countsByYear W42817382092023 @default.
• W4281738209 crossrefType "journal-article" @default.
• W4281738209 hasAuthorship W4281738209A5005119582 @default.
• W4281738209 hasAuthorship W4281738209A5023205278 @default.
• W4281738209 hasAuthorship W4281738209A5023993805 @default.
• W4281738209 hasAuthorship W4281738209A5036244788 @default.
• W4281738209 hasAuthorship W4281738209A5043218702 @default.
• W4281738209 hasAuthorship W4281738209A5046828437 @default.
• W4281738209 hasAuthorship W4281738209A5071820901 @default.
• W4281738209 hasAuthorship W4281738209A5073546855 @default.
• W4281738209 hasAuthorship W4281738209A5084952424 @default.
• W4281738209 hasBestOaLocation W42817382091 @default.
• W4281738209 hasConcept C111113717 @default.
• W4281738209 hasConcept C112705442 @default.
• W4281738209 hasConcept C126322002 @default.
• W4281738209 hasConcept C139254425 @default.
• W4281738209 hasConcept C176947019 @default.
• W4281738209 hasConcept C2777288759 @default.
• W4281738209 hasConcept C2781253189 @default.
• W4281738209 hasConcept C2781276175 @default.
• W4281738209 hasConcept C2908647359 @default.
• W4281738209 hasConcept C4937899 @default.
• W4281738209 hasConcept C501593827 @default.
• W4281738209 hasConcept C71924100 @default.
• W4281738209 hasConcept C86803240 @default.
• W4281738209 hasConcept C89423630 @default.
• W4281738209 hasConcept C98274493 @default.
• W4281738209 hasConcept C99454951 @default.
• W4281738209 hasConceptScore W4281738209C111113717 @default.
• W4281738209 hasConceptScore W4281738209C112705442 @default.
• W4281738209 hasConceptScore W4281738209C126322002 @default.
• W4281738209 hasConceptScore W4281738209C139254425 @default.
• W4281738209 hasConceptScore W4281738209C176947019 @default.
• W4281738209 hasConceptScore W4281738209C2777288759 @default.
• W4281738209 hasConceptScore W4281738209C2781253189 @default.
• W4281738209 hasConceptScore W4281738209C2781276175 @default.
• W4281738209 hasConceptScore W4281738209C2908647359 @default.
• W4281738209 hasConceptScore W4281738209C4937899 @default.
• W4281738209 hasConceptScore W4281738209C501593827 @default.
• W4281738209 hasConceptScore W4281738209C71924100 @default.
• W4281738209 hasConceptScore W4281738209C86803240 @default.
• W4281738209 hasConceptScore W4281738209C89423630 @default.
• W4281738209 hasConceptScore W4281738209C98274493 @default.
• W4281738209 hasConceptScore W4281738209C99454951 @default.
• W4281738209 hasIssue "1" @default.
• W4281738209 hasLocation W42817382091 @default.
• W4281738209 hasLocation W42817382092 @default.
• W4281738209 hasLocation W42817382093 @default.
• W4281738209 hasLocation W42817382094 @default.
• W4281738209 hasLocation W42817382095 @default.
• W4281738209 hasOpenAccess W4281738209 @default.
• W4281738209 hasPrimaryLocation W42817382091 @default.
• W4281738209 hasRelatedWork W1966718042 @default.

• next