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- W4281738265 abstract "Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD subunit structure requires quaternary interactions is unclear. Here, we present crystal structures of a set of bacterial voltage-gated sodium channel (BacNaV) 'pore only' proteins that reveal a surprising collection of non-canonical quaternary arrangements in which the PD tertiary structure is maintained. This context-independent structural robustness, supported by molecular dynamics simulations, indicates that VGIC-PD tertiary structure is independent of quaternary interactions. This fold occurs throughout the VGIC superfamily and in diverse transmembrane and soluble proteins. Strikingly, characterization of PD subunit-binding Fabs indicates that non-canonical quaternary PD conformations can occur in full-length VGICs. Together, our data demonstrate that the VGIC-PD is an autonomously folded unit. This property has implications for VGIC biogenesis, understanding functional states, de novo channel design, and VGIC structural origins." @default.
- W4281738265 created "2022-06-13" @default.
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- W4281738265 date "2022-06-01" @default.
- W4281738265 modified "2023-09-27" @default.
- W4281738265 title "Quaternary structure independent folding of voltage-gated ion channel pore domain subunits" @default.
- W4281738265 cites W1486424025 @default.
- W4281738265 cites W1540419168 @default.
- W4281738265 cites W1598629441 @default.
- W4281738265 cites W1726597626 @default.
- W4281738265 cites W1804471599 @default.
- W4281738265 cites W1838780003 @default.
- W4281738265 cites W1954772973 @default.
- W4281738265 cites W1961177618 @default.
- W4281738265 cites W1966081935 @default.
- W4281738265 cites W1969549030 @default.
- W4281738265 cites W1971251199 @default.
- W4281738265 cites W1976499671 @default.
- W4281738265 cites W1976672416 @default.
- W4281738265 cites W1978189250 @default.
- W4281738265 cites W1983335488 @default.
- W4281738265 cites W1992864587 @default.
- W4281738265 cites W1995017064 @default.
- W4281738265 cites W1999805574 @default.
- W4281738265 cites W2001831786 @default.
- W4281738265 cites W2005574282 @default.
- W4281738265 cites W2011683030 @default.
- W4281738265 cites W2017421343 @default.
- W4281738265 cites W2017522634 @default.
- W4281738265 cites W2019425225 @default.
- W4281738265 cites W2020448043 @default.
- W4281738265 cites W2027711565 @default.
- W4281738265 cites W2030517878 @default.
- W4281738265 cites W2045502034 @default.
- W4281738265 cites W2054058473 @default.
- W4281738265 cites W2055983112 @default.
- W4281738265 cites W2071849521 @default.
- W4281738265 cites W2072220895 @default.
- W4281738265 cites W2101299936 @default.
- W4281738265 cites W2103590593 @default.
- W4281738265 cites W2103945336 @default.
- W4281738265 cites W2104415321 @default.
- W4281738265 cites W2107537025 @default.
- W4281738265 cites W2110808180 @default.
- W4281738265 cites W2122994276 @default.
- W4281738265 cites W2126855756 @default.
- W4281738265 cites W2131019217 @default.
- W4281738265 cites W2131350133 @default.
- W4281738265 cites W2134762386 @default.
- W4281738265 cites W2144081223 @default.
- W4281738265 cites W2144420181 @default.
- W4281738265 cites W2147949826 @default.
- W4281738265 cites W2159211495 @default.
- W4281738265 cites W2160384970 @default.
- W4281738265 cites W2161962584 @default.
- W4281738265 cites W2162314649 @default.
- W4281738265 cites W2162746575 @default.
- W4281738265 cites W2167460294 @default.
- W4281738265 cites W2168174140 @default.
- W4281738265 cites W2180229411 @default.
- W4281738265 cites W2217487925 @default.
- W4281738265 cites W2267132526 @default.
- W4281738265 cites W2278844416 @default.
- W4281738265 cites W2313116527 @default.
- W4281738265 cites W2323104785 @default.
- W4281738265 cites W2332712348 @default.
- W4281738265 cites W2339750916 @default.
- W4281738265 cites W2342569995 @default.
- W4281738265 cites W2404280981 @default.
- W4281738265 cites W2412732575 @default.
- W4281738265 cites W2508657279 @default.
- W4281738265 cites W2530496880 @default.
- W4281738265 cites W2552101241 @default.
- W4281738265 cites W2605647331 @default.
- W4281738265 cites W2607853144 @default.
- W4281738265 cites W2724716579 @default.
- W4281738265 cites W2765322245 @default.
- W4281738265 cites W2769902750 @default.
- W4281738265 cites W2781196872 @default.
- W4281738265 cites W2887354287 @default.
- W4281738265 cites W2916889802 @default.
- W4281738265 cites W2924493367 @default.
- W4281738265 cites W2999250470 @default.
- W4281738265 cites W3042551908 @default.
- W4281738265 cites W3102369606 @default.