FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281738302> ?p ?o ?g. }

• W4281738302 abstract "Abstract The advancement of microgravity simulators is helping many researchers better understanding the impact of the mechanically unloaded space environment on cellular function and disfunction. However, performing microgravity experiments on Earth, using simulators such as the Random Positioning Machine, introduces some unique practical challenges, including air bubble formation and leakage of growth medium from tissue culture flask and plates, all of which limit research progress. Here, we developed an easy-to-use hybrid biological platform designed with the precision of 3D printing technologies combined with PDMS microfluidic fabrication processes to facilitate reliable and reproducible microgravity cellular experiments. The system has been characterized for applications in the contest of brain cancer research by exposing glioblastoma and endothelial cells to 24 h of simulated microgravity condition to investigate the triggered mechanosensing pathways involved in cellular adaptation to the new environment. The platform demonstrated compatibility with different biological assays, i.e., proliferation, viability, morphology, protein expression and imaging of molecular structures, showing advantages over the conventional usage of culture flask. Our results indicated that both cell types are susceptible when the gravitational vector is disrupted, confirming the impact that microgravity has on both cancer and healthy cells functionality. In particular, we observed deactivation of Yap-1 molecule in glioblastoma cells and the remodeling of VE-Cadherin junctional protein in endothelial cells. The study provides support for the application of the proposed biological platform for advancing space mechanobiology research, also highlighting perspectives and strategies for developing next generation of brain cancer molecular therapies, including targeted drug delivery strategies." @default.
• W4281738302 created "2022-06-13" @default.
• W4281738302 creator A5007328609 @default.
• W4281738302 creator A5007731204 @default.
• W4281738302 creator A5020951795 @default.
• W4281738302 creator A5032199054 @default.
• W4281738302 creator A5035726422 @default.
• W4281738302 creator A5040308377 @default.
• W4281738302 creator A5070609220 @default.
• W4281738302 date "2022-06-03" @default.
• W4281738302 modified "2023-09-30" @default.
• W4281738302 title "Testing 3D printed biological platform for advancing simulated microgravity and space mechanobiology research" @default.
• W4281738302 cites W1568395597 @default.
• W4281738302 cites W1593844282 @default.
• W4281738302 cites W1973853894 @default.
• W4281738302 cites W1980059877 @default.
• W4281738302 cites W1982370874 @default.
• W4281738302 cites W1986189363 @default.
• W4281738302 cites W1986868649 @default.
• W4281738302 cites W1993429855 @default.
• W4281738302 cites W2001742339 @default.
• W4281738302 cites W2032658227 @default.
• W4281738302 cites W2040593473 @default.
• W4281738302 cites W2049136921 @default.
• W4281738302 cites W2049532810 @default.
• W4281738302 cites W2059971022 @default.
• W4281738302 cites W2062409563 @default.
• W4281738302 cites W2079566559 @default.
• W4281738302 cites W2081382498 @default.
• W4281738302 cites W2087153492 @default.
• W4281738302 cites W2102661335 @default.
• W4281738302 cites W2103224183 @default.
• W4281738302 cites W2110778204 @default.
• W4281738302 cites W2112635797 @default.
• W4281738302 cites W2121636548 @default.
• W4281738302 cites W2127675271 @default.
• W4281738302 cites W2134873228 @default.
• W4281738302 cites W2149087782 @default.
• W4281738302 cites W2149162919 @default.
• W4281738302 cites W2158678196 @default.
• W4281738302 cites W2160373069 @default.
• W4281738302 cites W2174517496 @default.
• W4281738302 cites W2290063375 @default.
• W4281738302 cites W2324443299 @default.
• W4281738302 cites W2332615956 @default.
• W4281738302 cites W2416414475 @default.
• W4281738302 cites W2426003472 @default.
• W4281738302 cites W2495536684 @default.
• W4281738302 cites W2515781937 @default.
• W4281738302 cites W2516386574 @default.
• W4281738302 cites W2520953378 @default.
• W4281738302 cites W2563463703 @default.
• W4281738302 cites W2606271937 @default.
• W4281738302 cites W2614669617 @default.
• W4281738302 cites W2741378408 @default.
• W4281738302 cites W2742440932 @default.
• W4281738302 cites W2765228196 @default.
• W4281738302 cites W2768414327 @default.
• W4281738302 cites W2773841619 @default.
• W4281738302 cites W2806013815 @default.
• W4281738302 cites W2885081622 @default.
• W4281738302 cites W2900664177 @default.
• W4281738302 cites W2921139978 @default.
• W4281738302 cites W2946199561 @default.
• W4281738302 cites W2954979301 @default.
• W4281738302 cites W2991279836 @default.
• W4281738302 cites W3008258085 @default.
• W4281738302 cites W3011083933 @default.
• W4281738302 cites W3022626511 @default.
• W4281738302 cites W3114753755 @default.
• W4281738302 cites W3120161468 @default.
• W4281738302 cites W3126999737 @default.
• W4281738302 cites W3127702166 @default.
• W4281738302 cites W3188182783 @default.
• W4281738302 cites W4206161075 @default.
• W4281738302 doi "https://doi.org/10.1038/s41526-022-00207-6" @default.
• W4281738302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35662260" @default.
• W4281738302 hasPublicationYear "2022" @default.
• W4281738302 type Work @default.
• W4281738302 citedByCount "3" @default.
• W4281738302 countsByYear W42817383022022 @default.
• W4281738302 countsByYear W42817383022023 @default.
• W4281738302 crossrefType "journal-article" @default.
• W4281738302 hasAuthorship W4281738302A5007328609 @default.
• W4281738302 hasAuthorship W4281738302A5007731204 @default.
• W4281738302 hasAuthorship W4281738302A5020951795 @default.
• W4281738302 hasAuthorship W4281738302A5032199054 @default.
• W4281738302 hasAuthorship W4281738302A5035726422 @default.
• W4281738302 hasAuthorship W4281738302A5040308377 @default.
• W4281738302 hasAuthorship W4281738302A5070609220 @default.
• W4281738302 hasBestOaLocation W42817383021 @default.
• W4281738302 hasConcept C127413603 @default.
• W4281738302 hasConcept C136229726 @default.
• W4281738302 hasConcept C165932988 @default.
• W4281738302 hasConcept C171250308 @default.
• W4281738302 hasConcept C192562407 @default.
• W4281738302 hasConcept C2779820397 @default.
• W4281738302 hasConcept C2780171871 @default.
• W4281738302 hasConcept C41008148 @default.
• W4281738302 hasConcept C49892992 @default.

• next