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- W4281738307 endingPage "1160" @default.
- W4281738307 startingPage "1160" @default.
- W4281738307 abstract "Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer activity. This study was designed, for the first time, to load Ap into chitosan to improve its hydrophobicity and then it was coated with albumin-folic acid to increase its stability and bioavailability and to target cancer cells. The newly developed encapsulated Ap (Ap-CH-BSA-FANPs) was characterized and tested in vitro. The zeta potential of −17.0 mV was within the recommended range (−30 mV to +30 mV), indicating that encapsulated apigenin would not quickly settle and would be suspended. The in vitro results proved the great anticancer activity of the encapsulated apigenin on HePG-2 cells compared to pure Ap. The treated HePG-2 cells with Ap-CH-BSA-FANPs demonstrated the induction of apoptosis by increasing p53 gene expression, arresting the cell cycle, increasing caspase-9 levels, and decreasing both the MMP9 gene and Bcl-2 protein expression levels. Moreover, the higher antioxidant activity of the encapsulated apigenin treatment was evident through increasing SOD levels and decreasing the CAT concentration. In conclusion, the Ap-CH-BSA-FANPs were easy to produce with low coast, continued drug release, good loading capacity, high solubility in physiological pH, and were more stable than the formerly Ap-loaded liposomes or PLGA. Moreover, Ap-CH-BSA-FANPs may be a promising chemotherapeutic agent in the treatment of HCC." @default.
- W4281738307 created "2022-06-13" @default.
- W4281738307 creator A5003261363 @default.
- W4281738307 creator A5014971889 @default.
- W4281738307 creator A5057413296 @default.
- W4281738307 creator A5071676113 @default.
- W4281738307 date "2022-05-29" @default.
- W4281738307 modified "2023-10-01" @default.
- W4281738307 title "The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53" @default.
- W4281738307 cites W1505393660 @default.
- W4281738307 cites W1970442695 @default.
- W4281738307 cites W1971533349 @default.
- W4281738307 cites W1976129366 @default.
- W4281738307 cites W1979951564 @default.
- W4281738307 cites W1990218909 @default.
- W4281738307 cites W1992588954 @default.
- W4281738307 cites W1992885568 @default.
- W4281738307 cites W1994059078 @default.
- W4281738307 cites W1994682335 @default.
- W4281738307 cites W2003307182 @default.
- W4281738307 cites W2007453791 @default.
- W4281738307 cites W2007833062 @default.
- W4281738307 cites W2008353852 @default.
- W4281738307 cites W2023460940 @default.
- W4281738307 cites W2027216206 @default.
- W4281738307 cites W2036817490 @default.
- W4281738307 cites W2042753075 @default.
- W4281738307 cites W2043106306 @default.
- W4281738307 cites W2045380897 @default.
- W4281738307 cites W2055206436 @default.
- W4281738307 cites W2057193930 @default.
- W4281738307 cites W2073593514 @default.
- W4281738307 cites W2075088335 @default.
- W4281738307 cites W2079475594 @default.
- W4281738307 cites W2081699180 @default.
- W4281738307 cites W2096928036 @default.
- W4281738307 cites W2104014368 @default.
- W4281738307 cites W2116376218 @default.
- W4281738307 cites W2119098656 @default.
- W4281738307 cites W2124176776 @default.
- W4281738307 cites W2132192234 @default.
- W4281738307 cites W2148489388 @default.
- W4281738307 cites W2151277007 @default.
- W4281738307 cites W2169419625 @default.
- W4281738307 cites W2172589846 @default.
- W4281738307 cites W2173735004 @default.
- W4281738307 cites W2248252381 @default.
- W4281738307 cites W2269729332 @default.
- W4281738307 cites W2297295275 @default.
- W4281738307 cites W2325138196 @default.
- W4281738307 cites W2410832741 @default.
- W4281738307 cites W2415945663 @default.
- W4281738307 cites W2524259179 @default.
- W4281738307 cites W2560550958 @default.
- W4281738307 cites W2579307322 @default.
- W4281738307 cites W2581156138 @default.
- W4281738307 cites W2587781025 @default.
- W4281738307 cites W2589805231 @default.
- W4281738307 cites W2594348115 @default.
- W4281738307 cites W2597194099 @default.
- W4281738307 cites W2597228015 @default.
- W4281738307 cites W2605669332 @default.
- W4281738307 cites W2607265228 @default.
- W4281738307 cites W2610013822 @default.
- W4281738307 cites W2731101048 @default.
- W4281738307 cites W2747860587 @default.
- W4281738307 cites W2763410913 @default.
- W4281738307 cites W2765596630 @default.
- W4281738307 cites W2783272794 @default.
- W4281738307 cites W2792945152 @default.
- W4281738307 cites W2802210553 @default.
- W4281738307 cites W2802723445 @default.
- W4281738307 cites W2804374086 @default.
- W4281738307 cites W2808399951 @default.
- W4281738307 cites W2810673358 @default.
- W4281738307 cites W2891522100 @default.
- W4281738307 cites W2902031025 @default.
- W4281738307 cites W2903288214 @default.
- W4281738307 cites W2921026906 @default.
- W4281738307 cites W2937977485 @default.
- W4281738307 cites W2945481870 @default.
- W4281738307 cites W2968131518 @default.
- W4281738307 cites W2980663696 @default.
- W4281738307 cites W2992786191 @default.
- W4281738307 cites W2994829842 @default.
- W4281738307 cites W3006601229 @default.
- W4281738307 cites W3008231138 @default.
- W4281738307 cites W3021396592 @default.
- W4281738307 cites W3028553592 @default.
- W4281738307 cites W3031636899 @default.
- W4281738307 cites W3082220382 @default.
- W4281738307 cites W3090905510 @default.
- W4281738307 cites W3093318878 @default.
- W4281738307 cites W3093979249 @default.
- W4281738307 cites W3096426666 @default.
- W4281738307 cites W3134219978 @default.
- W4281738307 cites W3149491847 @default.
- W4281738307 cites W3153003521 @default.