Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281738580> ?p ?o ?g. }
- W4281738580 abstract "Summary Light touch sensation begins with activation of low-threshold mechanoreceptor (LTMR) endings in the skin and propagation of their signals to the spinal cord and brainstem. We found that the clustered protocadherin gamma ( Pcdhg ) gene locus, which encodes 22 cell-surface homophilic binding proteins, is required in somatosensory neurons for normal behavioral reactivity to a range of tactile stimuli. Developmentally, distinct Pcdhg isoforms mediate LTMR synapse formation through neuron-neuron interactions and peripheral axonal branching through neuron-glia interactions. The Pcdhgc3 isoform mediates homophilic interactions between sensory axons and spinal cord neurons to promote synapse formation in vivo , and is sufficient to induce postsynaptic specializations in vitro . Moreover, loss of Pcdhgs and somatosensory synaptic inputs to the dorsal horn lead to fewer corticospinal synapses onto dorsal horn neurons. These findings reveal essential roles for Pcdhg isoform diversity in somatosensory neuron synapse formation, peripheral axonal branching, and step-wise assembly of central mechanosensory circuitry." @default.
- W4281738580 created "2022-06-13" @default.
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- W4281738580 date "2022-05-25" @default.
- W4281738580 modified "2023-10-17" @default.
- W4281738580 title "γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons" @default.
- W4281738580 cites W133424498 @default.
- W4281738580 cites W1583092199 @default.
- W4281738580 cites W1867481372 @default.
- W4281738580 cites W1919609383 @default.
- W4281738580 cites W1945370105 @default.
- W4281738580 cites W1969742525 @default.
- W4281738580 cites W1971401852 @default.
- W4281738580 cites W1977630276 @default.
- W4281738580 cites W1978271409 @default.
- W4281738580 cites W1978646107 @default.
- W4281738580 cites W1983845889 @default.
- W4281738580 cites W1987429832 @default.
- W4281738580 cites W1988120710 @default.
- W4281738580 cites W1989500792 @default.
- W4281738580 cites W1992442603 @default.
- W4281738580 cites W1995570794 @default.
- W4281738580 cites W1998594996 @default.
- W4281738580 cites W1999712387 @default.
- W4281738580 cites W2012265686 @default.
- W4281738580 cites W2013951425 @default.
- W4281738580 cites W2018793885 @default.
- W4281738580 cites W2020869819 @default.
- W4281738580 cites W2023179463 @default.
- W4281738580 cites W2027545565 @default.
- W4281738580 cites W2028807389 @default.
- W4281738580 cites W2029749895 @default.
- W4281738580 cites W2031627559 @default.
- W4281738580 cites W2033072655 @default.
- W4281738580 cites W2035158250 @default.
- W4281738580 cites W2037497313 @default.
- W4281738580 cites W2038587881 @default.
- W4281738580 cites W2039899111 @default.
- W4281738580 cites W2042920344 @default.
- W4281738580 cites W2047378045 @default.
- W4281738580 cites W2047804311 @default.
- W4281738580 cites W2048516550 @default.
- W4281738580 cites W2050868489 @default.
- W4281738580 cites W2051147717 @default.
- W4281738580 cites W2070372326 @default.
- W4281738580 cites W2070732190 @default.
- W4281738580 cites W2076018286 @default.
- W4281738580 cites W2081237481 @default.
- W4281738580 cites W2082023836 @default.
- W4281738580 cites W2083824794 @default.
- W4281738580 cites W2091069207 @default.
- W4281738580 cites W2094627731 @default.
- W4281738580 cites W2102232105 @default.
- W4281738580 cites W2104580322 @default.
- W4281738580 cites W2107634021 @default.
- W4281738580 cites W2110233724 @default.
- W4281738580 cites W2116733131 @default.
- W4281738580 cites W2117632186 @default.
- W4281738580 cites W2120369399 @default.
- W4281738580 cites W2124790162 @default.
- W4281738580 cites W2126617902 @default.
- W4281738580 cites W2132637814 @default.
- W4281738580 cites W2144161917 @default.
- W4281738580 cites W2145935221 @default.
- W4281738580 cites W2146152985 @default.
- W4281738580 cites W2150192750 @default.
- W4281738580 cites W2150909590 @default.
- W4281738580 cites W2152970852 @default.
- W4281738580 cites W2153968156 @default.
- W4281738580 cites W2155899899 @default.
- W4281738580 cites W2162056974 @default.
- W4281738580 cites W2168153190 @default.
- W4281738580 cites W2168423195 @default.
- W4281738580 cites W2169109050 @default.
- W4281738580 cites W2169456326 @default.
- W4281738580 cites W2179438025 @default.
- W4281738580 cites W2220753543 @default.
- W4281738580 cites W2332229588 @default.
- W4281738580 cites W2345554661 @default.
- W4281738580 cites W2381891294 @default.
- W4281738580 cites W2411027809 @default.
- W4281738580 cites W2415803194 @default.
- W4281738580 cites W2475437687 @default.
- W4281738580 cites W2512007269 @default.
- W4281738580 cites W2512878401 @default.