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- W4281741567 abstract "To date, the treatment option for tachyarrhythmia is classified into drug therapy, catheter ablation, and implantable device therapy. However, the efficacy of the antiarrhythmic drugs is limited. Although the indication of catheter ablation is expanding, several fatal tachyarrhythmias are still refractory to ablation. Implantable cardioverter-defibrillator increases survival, but it is not a curable treatment. Therefore, a novel therapy for tachyarrhythmias refractory to present treatments is desired. Gene therapy is being developed as a promising candidate for this purpose, and basic research and translational research have been accumulated in recent years.This paper reviews the current state of gene therapy for arrhythmias, including susceptible arrhythmias, the route of administration to the heart, and the type of vector to use. We also discuss the latest progress in the technology of gene delivery and genome editing.Gene therapy is one of the most promising technologies for arrhythmia treatment. However, additional technological innovation to achieve safe, localized, homogeneous, and long-lasting gene transfer is required for its clinical application." @default.
- W4281741567 created "2022-06-13" @default.
- W4281741567 creator A5005948118 @default.
- W4281741567 creator A5005987910 @default.
- W4281741567 creator A5064015226 @default.
- W4281741567 date "2022-06-02" @default.
- W4281741567 modified "2023-10-18" @default.
- W4281741567 title "Gene therapy to terminate tachyarrhythmias" @default.
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