Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281743018> ?p ?o ?g. }
- W4281743018 endingPage "102132" @default.
- W4281743018 startingPage "102132" @default.
- W4281743018 abstract "Tau aggregation underlies neurodegenerative tauopathies, and transcellular propagation of tau assemblies of unique structure, i.e., strains, may underlie the diversity of these disorders. Polyanions have been reported to induce tau aggregation in vitro, but the precise trigger to convert tau from an inert to a seed-competent form in disease states is unknown. RNA triggers tau fibril formation in vitro and has been observed to associate with neurofibrillary tangles in human brain. Here, we have tested whether RNA exerts sequence-specific effects on tau assembly and strain formation. We found that three RNA homopolymers, polyA, polyU, and polyC, all bound tau, but only polyA RNA triggered seed and fibril formation. In addition, polyA:tau seeds and fibrils were sensitive to RNase. We also observed that the origin of the RNA influenced the ability of tau to adopt a structure that would form stable strains. Human RNA potently induced tau seed formation and created tau conformations that preferentially formed stable strains in a HEK293T cell model, whereas RNA from other sources, or heparin, produced strains that were not stably maintained in cultured cells. Finally, we found that soluble, but not insoluble seeds from Alzheimer's disease brain were also sensitive to RNase. We conclude that human RNA specifically induces formation of stable tau strains and may trigger the formation of dominant pathological assemblies that propagate in Alzheimer's disease and possibly other tauopathies." @default.
- W4281743018 created "2022-06-13" @default.
- W4281743018 creator A5013978422 @default.
- W4281743018 creator A5024767343 @default.
- W4281743018 creator A5025605315 @default.
- W4281743018 creator A5055558604 @default.
- W4281743018 creator A5066343613 @default.
- W4281743018 creator A5076273713 @default.
- W4281743018 date "2022-08-01" @default.
- W4281743018 modified "2023-09-26" @default.
- W4281743018 title "RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds" @default.
- W4281743018 cites W1177858961 @default.
- W4281743018 cites W1491450727 @default.
- W4281743018 cites W1966312717 @default.
- W4281743018 cites W1967285029 @default.
- W4281743018 cites W1975700794 @default.
- W4281743018 cites W1978278862 @default.
- W4281743018 cites W1987549963 @default.
- W4281743018 cites W1989208474 @default.
- W4281743018 cites W1994282166 @default.
- W4281743018 cites W1995737263 @default.
- W4281743018 cites W1997973599 @default.
- W4281743018 cites W2005483591 @default.
- W4281743018 cites W2006051211 @default.
- W4281743018 cites W2007636536 @default.
- W4281743018 cites W2010498006 @default.
- W4281743018 cites W2029543048 @default.
- W4281743018 cites W2034289842 @default.
- W4281743018 cites W2036008741 @default.
- W4281743018 cites W2040351396 @default.
- W4281743018 cites W2041655987 @default.
- W4281743018 cites W2053097655 @default.
- W4281743018 cites W2057033418 @default.
- W4281743018 cites W2057682957 @default.
- W4281743018 cites W2067540111 @default.
- W4281743018 cites W2075426349 @default.
- W4281743018 cites W2076847487 @default.
- W4281743018 cites W2078666749 @default.
- W4281743018 cites W2081966615 @default.
- W4281743018 cites W2087140195 @default.
- W4281743018 cites W2096321704 @default.
- W4281743018 cites W2099340107 @default.
- W4281743018 cites W2114185596 @default.
- W4281743018 cites W2118607691 @default.
- W4281743018 cites W2143216632 @default.
- W4281743018 cites W2153896793 @default.
- W4281743018 cites W2166315184 @default.
- W4281743018 cites W2176134948 @default.
- W4281743018 cites W2207904128 @default.
- W4281743018 cites W2287813183 @default.
- W4281743018 cites W2345763852 @default.
- W4281743018 cites W2529144260 @default.
- W4281743018 cites W2545421204 @default.
- W4281743018 cites W2608970480 @default.
- W4281743018 cites W2768176302 @default.
- W4281743018 cites W2803477192 @default.
- W4281743018 cites W2809298270 @default.
- W4281743018 cites W2872898993 @default.
- W4281743018 cites W2887193453 @default.
- W4281743018 cites W2895694428 @default.
- W4281743018 cites W2901138939 @default.
- W4281743018 cites W2905087948 @default.
- W4281743018 cites W2912165492 @default.
- W4281743018 cites W2914428966 @default.
- W4281743018 cites W2945882822 @default.
- W4281743018 cites W2949999790 @default.
- W4281743018 cites W2950027753 @default.
- W4281743018 cites W3012619974 @default.
- W4281743018 cites W3016184482 @default.
- W4281743018 cites W3025392446 @default.
- W4281743018 cites W3091374564 @default.
- W4281743018 cites W3102160053 @default.
- W4281743018 cites W3154112996 @default.
- W4281743018 cites W3165482231 @default.
- W4281743018 cites W3173324977 @default.
- W4281743018 cites W3174707083 @default.
- W4281743018 cites W3194761285 @default.
- W4281743018 cites W3198858130 @default.
- W4281743018 cites W4225544513 @default.
- W4281743018 cites W4362221370 @default.
- W4281743018 cites W47608607 @default.
- W4281743018 doi "https://doi.org/10.1016/j.jbc.2022.102132" @default.
- W4281743018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35700826" @default.
- W4281743018 hasPublicationYear "2022" @default.
- W4281743018 type Work @default.
- W4281743018 citedByCount "9" @default.
- W4281743018 countsByYear W42817430182022 @default.
- W4281743018 countsByYear W42817430182023 @default.
- W4281743018 crossrefType "journal-article" @default.
- W4281743018 hasAuthorship W4281743018A5013978422 @default.
- W4281743018 hasAuthorship W4281743018A5024767343 @default.
- W4281743018 hasAuthorship W4281743018A5025605315 @default.
- W4281743018 hasAuthorship W4281743018A5055558604 @default.
- W4281743018 hasAuthorship W4281743018A5066343613 @default.
- W4281743018 hasAuthorship W4281743018A5076273713 @default.
- W4281743018 hasBestOaLocation W42817430181 @default.
- W4281743018 hasConcept C104317684 @default.
- W4281743018 hasConcept C10879258 @default.