Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281744913> ?p ?o ?g. }
- W4281744913 abstract "Abstract Background Hashimoto's thyroiditis is the most widespread autoimmune illness targeting a specific organ. Redox homeostasis is achieved when the production of Reactive Oxygen Species and their elimination are in balance. Advanced glycation end products (AGEs) are formed when glucose and/or α -oxaloaldehydes react non-enzymatically with the amino groups of lipids, proteins, and DNA. Nowadays, many studies are concerned with AGEs, the polymorphisms of their receptors, and their association with increased risk of HT. However, few studies investigated the role of receptors of advanced glycation end product (RAGE) SNP in Egyptian females. Objective The goals of this investigation were to ascertain whether oxidative stress plasma malondialdehyde (MDA) and total antioxidant capacity (TAC) were associated with HT, in addition, to assess the association of RAGE polymorphisms (− 374 T > A and the − 429 T > C and Gly82Ser) with HT. Subject and methods. Our case–control study has 80 patients enrolled who have newly been diagnosed with HT and 80 age and sex-matched healthy female controls. Each participant underwent a thorough medical history, physical examination, and laboratory investigations, which included Genotyping of RAGE Gly82Ser, − 374 T > A and − 429 T > C using polymerase chain reaction-restriction fragment length polymorphisms (PCR–RFLP). Results Chi-square revealed a significant association regarding the distribution of RAGE (− 374 T < C) genotypes TT and CC between patients and control ( P = 0.04). Non-significant associations regarding the distribution of Gly82Ser genotypes Gly/Gly, Gly/Ser, Ser/Ser were found between patients and control ( P = 0.5), and non-significant associations related to − 429 T > C gene polymorphism were revealed. In addition, patients with HT had higher MDA and lower TCA compared with controls. Conclusion The elevated MDA and decreased TAC as an antioxidant may be one of several risk factors associated with the prevalence of HT in individuals with the − 429 T > C RAGE mutation polymorphism that is associated with an increased risk of HT in Egyptian females." @default.
- W4281744913 created "2022-06-13" @default.
- W4281744913 creator A5056441999 @default.
- W4281744913 creator A5063525621 @default.
- W4281744913 date "2022-05-31" @default.
- W4281744913 modified "2023-09-30" @default.
- W4281744913 title "Receptor of advanced glycation end product (RAGE) polymorphism and oxidative status in Hashimoto’s thyroiditis in Egyptian female patients: case control study" @default.
- W4281744913 cites W1503258737 @default.
- W4281744913 cites W1590457525 @default.
- W4281744913 cites W1896386433 @default.
- W4281744913 cites W1967303459 @default.
- W4281744913 cites W1968619160 @default.
- W4281744913 cites W1973841538 @default.
- W4281744913 cites W1979915044 @default.
- W4281744913 cites W1983937216 @default.
- W4281744913 cites W1994774717 @default.
- W4281744913 cites W1997559842 @default.
- W4281744913 cites W2001573394 @default.
- W4281744913 cites W2003304904 @default.
- W4281744913 cites W2005299533 @default.
- W4281744913 cites W2013339768 @default.
- W4281744913 cites W2037636911 @default.
- W4281744913 cites W2039402104 @default.
- W4281744913 cites W2039576356 @default.
- W4281744913 cites W2049587500 @default.
- W4281744913 cites W2051289988 @default.
- W4281744913 cites W2051379050 @default.
- W4281744913 cites W2070314465 @default.
- W4281744913 cites W2070888838 @default.
- W4281744913 cites W2073603780 @default.
- W4281744913 cites W2088359037 @default.
- W4281744913 cites W2091723265 @default.
- W4281744913 cites W2110465047 @default.
- W4281744913 cites W2117147802 @default.
- W4281744913 cites W2118090983 @default.
- W4281744913 cites W2129660051 @default.
- W4281744913 cites W2143912907 @default.
- W4281744913 cites W2145670359 @default.
- W4281744913 cites W2160479442 @default.
- W4281744913 cites W2163194813 @default.
- W4281744913 cites W2165201727 @default.
- W4281744913 cites W2165797824 @default.
- W4281744913 cites W2257709342 @default.
- W4281744913 cites W2591477525 @default.
- W4281744913 doi "https://doi.org/10.1186/s43042-022-00311-y" @default.
- W4281744913 hasPublicationYear "2022" @default.
- W4281744913 type Work @default.
- W4281744913 citedByCount "0" @default.
- W4281744913 crossrefType "journal-article" @default.
- W4281744913 hasAuthorship W4281744913A5056441999 @default.
- W4281744913 hasAuthorship W4281744913A5063525621 @default.
- W4281744913 hasBestOaLocation W42817449131 @default.
- W4281744913 hasConcept C104317684 @default.
- W4281744913 hasConcept C126322002 @default.
- W4281744913 hasConcept C134018914 @default.
- W4281744913 hasConcept C135763542 @default.
- W4281744913 hasConcept C146304588 @default.
- W4281744913 hasConcept C147990577 @default.
- W4281744913 hasConcept C169760540 @default.
- W4281744913 hasConcept C170493617 @default.
- W4281744913 hasConcept C203014093 @default.
- W4281744913 hasConcept C2776151105 @default.
- W4281744913 hasConcept C2776997535 @default.
- W4281744913 hasConcept C2778401633 @default.
- W4281744913 hasConcept C2778857457 @default.
- W4281744913 hasConcept C55493867 @default.
- W4281744913 hasConcept C71924100 @default.
- W4281744913 hasConcept C86803240 @default.
- W4281744913 hasConceptScore W4281744913C104317684 @default.
- W4281744913 hasConceptScore W4281744913C126322002 @default.
- W4281744913 hasConceptScore W4281744913C134018914 @default.
- W4281744913 hasConceptScore W4281744913C135763542 @default.
- W4281744913 hasConceptScore W4281744913C146304588 @default.
- W4281744913 hasConceptScore W4281744913C147990577 @default.
- W4281744913 hasConceptScore W4281744913C169760540 @default.
- W4281744913 hasConceptScore W4281744913C170493617 @default.
- W4281744913 hasConceptScore W4281744913C203014093 @default.
- W4281744913 hasConceptScore W4281744913C2776151105 @default.
- W4281744913 hasConceptScore W4281744913C2776997535 @default.
- W4281744913 hasConceptScore W4281744913C2778401633 @default.
- W4281744913 hasConceptScore W4281744913C2778857457 @default.
- W4281744913 hasConceptScore W4281744913C55493867 @default.
- W4281744913 hasConceptScore W4281744913C71924100 @default.
- W4281744913 hasConceptScore W4281744913C86803240 @default.
- W4281744913 hasIssue "1" @default.
- W4281744913 hasLocation W42817449131 @default.
- W4281744913 hasOpenAccess W4281744913 @default.
- W4281744913 hasPrimaryLocation W42817449131 @default.
- W4281744913 hasRelatedWork W1995801352 @default.
- W4281744913 hasRelatedWork W2007723032 @default.
- W4281744913 hasRelatedWork W2044505313 @default.
- W4281744913 hasRelatedWork W2053863266 @default.
- W4281744913 hasRelatedWork W2069514570 @default.
- W4281744913 hasRelatedWork W2078213156 @default.
- W4281744913 hasRelatedWork W2111555573 @default.
- W4281744913 hasRelatedWork W2111868412 @default.
- W4281744913 hasRelatedWork W2118332826 @default.
- W4281744913 hasRelatedWork W2598626658 @default.
- W4281744913 hasVolume "23" @default.
- W4281744913 isParatext "false" @default.