FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281748943> ?p ?o ?g. }

• W4281748943 endingPage "100258" @default.
• W4281748943 startingPage "100258" @default.
• W4281748943 abstract "Several biochemical markers in blood correlate with the magnitude of brain injury and may be used to predict neurological outcome after cardiac arrest. We present a protocol for the evaluation of prognostic accuracy of brain injury markers after cardiac arrest. The aim is to define the best predictive marker and to establish clinically useful cut-off levels for routine implementation. Prospective international multicenter trial within the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial in collaboration with Roche Diagnostics International AG. Samples were collected 0, 24, 48, and 72 hours after randomisation (serum) and 0 and 48 hours after randomisation (plasma), and pre-analytically processed at each site before storage in a central biobank. Routine markers neuron-specific enolase (NSE) and S100B, and neurofilament light, total-tau and glial fibrillary acidic protein will be batch analysed using novel Elecsys® electrochemiluminescence immunoassays on a Cobas e601 instrument. Statistical analysis will be reported according to the Standards for Reporting Diagnostic accuracy studies (STARD) and will include comparisons for prediction of good versus poor functional outcome at six months post-arrest, by modified Rankin Scale (0–3 vs. 4–6), using logistic regression models and receiver operating characteristics curves, evaluation of mortality at six months according to biomarker levels and establishment of cut-off values for prediction of poor neurological outcome at 95–100% specificities. This prospective trial may establish a standard methodology and clinically appropriate cut-off levels for the optimal biomarker of brain injury which predicts poor neurological outcome after cardiac arrest." @default.
• W4281748943 created "2022-06-13" @default.
• W4281748943 creator A5006125692 @default.
• W4281748943 creator A5008449628 @default.
• W4281748943 creator A5011072535 @default.
• W4281748943 creator A5024824441 @default.
• W4281748943 creator A5025313057 @default.
• W4281748943 creator A5025393792 @default.
• W4281748943 creator A5028378751 @default.
• W4281748943 creator A5028430735 @default.
• W4281748943 creator A5039350794 @default.
• W4281748943 creator A5040516055 @default.
• W4281748943 creator A5042782218 @default.
• W4281748943 creator A5045448108 @default.
• W4281748943 creator A5045492650 @default.
• W4281748943 creator A5047574783 @default.
• W4281748943 creator A5048554491 @default.
• W4281748943 creator A5048814373 @default.
• W4281748943 creator A5050423418 @default.
• W4281748943 creator A5050892378 @default.
• W4281748943 creator A5054340252 @default.
• W4281748943 creator A5059874316 @default.
• W4281748943 creator A5065027400 @default.
• W4281748943 creator A5070361116 @default.
• W4281748943 creator A5070672893 @default.
• W4281748943 creator A5073355726 @default.
• W4281748943 creator A5080061407 @default.
• W4281748943 creator A5082080423 @default.
• W4281748943 creator A5082733354 @default.
• W4281748943 creator A5085317910 @default.
• W4281748943 creator A5091785793 @default.
• W4281748943 date "2022-06-01" @default.
• W4281748943 modified "2023-10-18" @default.
• W4281748943 title "Biomarkers of brain injury after cardiac arrest; a statistical analysis plan from the TTM2 trial biobank investigators" @default.
• W4281748943 cites W1581514961 @default.
• W4281748943 cites W1740216334 @default.
• W4281748943 cites W1916035025 @default.
• W4281748943 cites W2145089983 @default.
• W4281748943 cites W2162445884 @default.
• W4281748943 cites W2171886225 @default.
• W4281748943 cites W2554140915 @default.
• W4281748943 cites W2605190706 @default.
• W4281748943 cites W2626946155 @default.
• W4281748943 cites W2748406060 @default.
• W4281748943 cites W2754855597 @default.
• W4281748943 cites W2762884349 @default.
• W4281748943 cites W2881422919 @default.
• W4281748943 cites W2883751442 @default.
• W4281748943 cites W2899030792 @default.
• W4281748943 cites W2955650283 @default.
• W4281748943 cites W3011768553 @default.
• W4281748943 cites W3027909537 @default.
• W4281748943 cites W3080950432 @default.
• W4281748943 cites W3085509199 @default.
• W4281748943 cites W3171604783 @default.
• W4281748943 cites W3194870832 @default.
• W4281748943 cites W4205504537 @default.
• W4281748943 cites W3087078690 @default.
• W4281748943 doi "https://doi.org/10.1016/j.resplu.2022.100258" @default.
• W4281748943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35677835" @default.
• W4281748943 hasPublicationYear "2022" @default.
• W4281748943 type Work @default.
• W4281748943 citedByCount "1" @default.
• W4281748943 countsByYear W42817489432022 @default.
• W4281748943 crossrefType "journal-article" @default.
• W4281748943 hasAuthorship W4281748943A5006125692 @default.
• W4281748943 hasAuthorship W4281748943A5008449628 @default.
• W4281748943 hasAuthorship W4281748943A5011072535 @default.
• W4281748943 hasAuthorship W4281748943A5024824441 @default.
• W4281748943 hasAuthorship W4281748943A5025313057 @default.
• W4281748943 hasAuthorship W4281748943A5025393792 @default.
• W4281748943 hasAuthorship W4281748943A5028378751 @default.
• W4281748943 hasAuthorship W4281748943A5028430735 @default.
• W4281748943 hasAuthorship W4281748943A5039350794 @default.
• W4281748943 hasAuthorship W4281748943A5040516055 @default.
• W4281748943 hasAuthorship W4281748943A5042782218 @default.
• W4281748943 hasAuthorship W4281748943A5045448108 @default.
• W4281748943 hasAuthorship W4281748943A5045492650 @default.
• W4281748943 hasAuthorship W4281748943A5047574783 @default.
• W4281748943 hasAuthorship W4281748943A5048554491 @default.
• W4281748943 hasAuthorship W4281748943A5048814373 @default.
• W4281748943 hasAuthorship W4281748943A5050423418 @default.
• W4281748943 hasAuthorship W4281748943A5050892378 @default.
• W4281748943 hasAuthorship W4281748943A5054340252 @default.
• W4281748943 hasAuthorship W4281748943A5059874316 @default.
• W4281748943 hasAuthorship W4281748943A5065027400 @default.
• W4281748943 hasAuthorship W4281748943A5070361116 @default.
• W4281748943 hasAuthorship W4281748943A5070672893 @default.
• W4281748943 hasAuthorship W4281748943A5073355726 @default.
• W4281748943 hasAuthorship W4281748943A5080061407 @default.
• W4281748943 hasAuthorship W4281748943A5082080423 @default.
• W4281748943 hasAuthorship W4281748943A5082733354 @default.
• W4281748943 hasAuthorship W4281748943A5085317910 @default.
• W4281748943 hasAuthorship W4281748943A5091785793 @default.
• W4281748943 hasBestOaLocation W42817489431 @default.
• W4281748943 hasConcept C116567970 @default.
• W4281748943 hasConcept C126322002 @default.
• W4281748943 hasConcept C151956035 @default.

• next