Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281750551> ?p ?o ?g. }
- W4281750551 endingPage "59S" @default.
- W4281750551 startingPage "53S" @default.
- W4281750551 abstract "The most frequently studied target of neuroinflammation using PET is 18-kDa translocator protein, but its limitations have spurred the molecular imaging community to find more promising targets. This article reviews the development of PET radioligands for cyclooxygenase (COX) subtypes 1 and 2, enzymes that catalyze the production of inflammatory prostanoids in the periphery and brain. Although both isozymes produce the same precursor compound, prostaglandin H2, they have distinct functions based on their differential cellular localization in the periphery and brain. For example, COX-1 is located primarily in microglia, a resident inflammatory cell in the brain whose role in producing inflammatory cytokines is well documented. In contrast, COX-2 is located primarily in neurons and can be markedly upregulated by inflammatory and excitatory stimuli, but its functions are poorly understood. This article reviews these 2 isozymes as biomarkers of neuroinflammation, as well as the radioligands that have recently been developed to image them in animals and humans. To place this work into context, the properties of COX-1 and COX-2 are compared with 18-kDa translocator protein, with special consideration of their application in Alzheimer disease as a representative neurodegenerative disorder." @default.
- W4281750551 created "2022-06-13" @default.
- W4281750551 creator A5002224231 @default.
- W4281750551 creator A5025613428 @default.
- W4281750551 creator A5028761898 @default.
- W4281750551 creator A5048937067 @default.
- W4281750551 creator A5052949600 @default.
- W4281750551 creator A5055239365 @default.
- W4281750551 creator A5056919069 @default.
- W4281750551 creator A5060844942 @default.
- W4281750551 creator A5079125204 @default.
- W4281750551 creator A5081472959 @default.
- W4281750551 date "2022-06-01" @default.
- W4281750551 modified "2023-09-26" @default.
- W4281750551 title "Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia" @default.
- W4281750551 cites W1518533198 @default.
- W4281750551 cites W1549076190 @default.
- W4281750551 cites W1552707113 @default.
- W4281750551 cites W1967020236 @default.
- W4281750551 cites W1968418992 @default.
- W4281750551 cites W1971443047 @default.
- W4281750551 cites W1977967320 @default.
- W4281750551 cites W1982637771 @default.
- W4281750551 cites W2007325903 @default.
- W4281750551 cites W2008424322 @default.
- W4281750551 cites W2013777179 @default.
- W4281750551 cites W2018905034 @default.
- W4281750551 cites W2026321461 @default.
- W4281750551 cites W2026790885 @default.
- W4281750551 cites W2028770303 @default.
- W4281750551 cites W2031004403 @default.
- W4281750551 cites W2034662727 @default.
- W4281750551 cites W2041448791 @default.
- W4281750551 cites W2050489727 @default.
- W4281750551 cites W2050693842 @default.
- W4281750551 cites W2056384210 @default.
- W4281750551 cites W2066917853 @default.
- W4281750551 cites W2071716296 @default.
- W4281750551 cites W2074732906 @default.
- W4281750551 cites W2087855610 @default.
- W4281750551 cites W2088930618 @default.
- W4281750551 cites W2097585557 @default.
- W4281750551 cites W2099885559 @default.
- W4281750551 cites W2103312948 @default.
- W4281750551 cites W2108925673 @default.
- W4281750551 cites W2119730885 @default.
- W4281750551 cites W2120375220 @default.
- W4281750551 cites W2128680329 @default.
- W4281750551 cites W2146957909 @default.
- W4281750551 cites W2148836759 @default.
- W4281750551 cites W2150336097 @default.
- W4281750551 cites W2159733758 @default.
- W4281750551 cites W2339380182 @default.
- W4281750551 cites W2342502462 @default.
- W4281750551 cites W2343157050 @default.
- W4281750551 cites W2345206543 @default.
- W4281750551 cites W2611032031 @default.
- W4281750551 cites W2619298813 @default.
- W4281750551 cites W2769071992 @default.
- W4281750551 cites W2800703264 @default.
- W4281750551 cites W2804494927 @default.
- W4281750551 cites W2808144744 @default.
- W4281750551 cites W2810109776 @default.
- W4281750551 cites W2898401907 @default.
- W4281750551 cites W2898815529 @default.
- W4281750551 cites W2898872372 @default.
- W4281750551 cites W2907888739 @default.
- W4281750551 cites W2949280410 @default.
- W4281750551 cites W2976818169 @default.
- W4281750551 cites W2996102639 @default.
- W4281750551 cites W3021156198 @default.
- W4281750551 cites W3025691939 @default.
- W4281750551 cites W3093872762 @default.
- W4281750551 cites W3094213593 @default.
- W4281750551 cites W3122671860 @default.
- W4281750551 cites W3191428296 @default.
- W4281750551 cites W4254019069 @default.
- W4281750551 doi "https://doi.org/10.2967/jnumed.121.263199" @default.
- W4281750551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35649646" @default.
- W4281750551 hasPublicationYear "2022" @default.
- W4281750551 type Work @default.
- W4281750551 citedByCount "6" @default.
- W4281750551 countsByYear W42817505512022 @default.
- W4281750551 countsByYear W42817505512023 @default.
- W4281750551 crossrefType "journal-article" @default.
- W4281750551 hasAuthorship W4281750551A5002224231 @default.
- W4281750551 hasAuthorship W4281750551A5025613428 @default.
- W4281750551 hasAuthorship W4281750551A5028761898 @default.
- W4281750551 hasAuthorship W4281750551A5048937067 @default.
- W4281750551 hasAuthorship W4281750551A5052949600 @default.
- W4281750551 hasAuthorship W4281750551A5055239365 @default.
- W4281750551 hasAuthorship W4281750551A5056919069 @default.
- W4281750551 hasAuthorship W4281750551A5060844942 @default.
- W4281750551 hasAuthorship W4281750551A5079125204 @default.
- W4281750551 hasAuthorship W4281750551A5081472959 @default.
- W4281750551 hasBestOaLocation W42817505511 @default.
- W4281750551 hasConcept C119795356 @default.
- W4281750551 hasConcept C142724271 @default.