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- W4281752600 abstract "How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem and discriminate between normal and malignant epithelial cells. We identify spatial biomarkers of tumors and their surrounding stroma that reinforce the heterogeneity of each tissue type. Combining pseudotime, RNA velocity–PAGA, cellular entropy, and regulon analysis in stromal cells reveals a cancer-specific rewiring of fibroblasts, where STAT1, TGF-β, and inflammatory signals induce a noncanonical WNT5A program that maintains the stromal inflammatory state. Cell-cell communication modeling suggests that tumors respond to the sudden burst of fibroblast-specific inflammatory signaling pathways by producing heat shock proteins, whose expression we validated in situ. Last, dose-dependent treatment with an HSP70 inhibitor suppresses in vitro vismodegib-resistant BCC cell growth, Hedgehog signaling, and in vivo tumor growth in a BCC mouse model, validating HSP70’s essential role in tumor growth and reinforcing the critical nature of tumor microenvironment cross-talk in BCC progression." @default.
- W4281752600 created "2022-06-13" @default.
- W4281752600 creator A5028749336 @default.
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- W4281752600 creator A5091529238 @default.
- W4281752600 date "2022-06-10" @default.
- W4281752600 modified "2023-09-30" @default.
- W4281752600 title "Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment" @default.
- W4281752600 cites W1833106472 @default.
- W4281752600 cites W1963863438 @default.
- W4281752600 cites W1970915933 @default.
- W4281752600 cites W1984883254 @default.
- W4281752600 cites W1986357982 @default.
- W4281752600 cites W1991546537 @default.
- W4281752600 cites W2019667717 @default.
- W4281752600 cites W2038527313 @default.
- W4281752600 cites W2068886994 @default.
- W4281752600 cites W2070050178 @default.
- W4281752600 cites W2071994905 @default.
- W4281752600 cites W2090499267 @default.
- W4281752600 cites W2091098473 @default.
- W4281752600 cites W2098425296 @default.
- W4281752600 cites W2098659547 @default.
- W4281752600 cites W2102212449 @default.
- W4281752600 cites W2105393937 @default.
- W4281752600 cites W2108444995 @default.
- W4281752600 cites W2108862219 @default.
- W4281752600 cites W2121998739 @default.
- W4281752600 cites W2127438438 @default.
- W4281752600 cites W2130410032 @default.
- W4281752600 cites W2135553161 @default.
- W4281752600 cites W2139465513 @default.
- W4281752600 cites W2141233707 @default.
- W4281752600 cites W2146749615 @default.
- W4281752600 cites W2146994504 @default.
- W4281752600 cites W2167279371 @default.
- W4281752600 cites W2168591146 @default.
- W4281752600 cites W2179438025 @default.
- W4281752600 cites W2273101790 @default.
- W4281752600 cites W2293178613 @default.
- W4281752600 cites W2332292689 @default.
- W4281752600 cites W2345356016 @default.
- W4281752600 cites W2473407440 @default.
- W4281752600 cites W2517068497 @default.
- W4281752600 cites W2553776432 @default.
- W4281752600 cites W2606156013 @default.
- W4281752600 cites W2614019591 @default.
- W4281752600 cites W2616922646 @default.
- W4281752600 cites W2747877289 @default.
- W4281752600 cites W2760955409 @default.
- W4281752600 cites W2766689134 @default.
- W4281752600 cites W2775613661 @default.
- W4281752600 cites W2785713700 @default.
- W4281752600 cites W2786577426 @default.
- W4281752600 cites W2787477673 @default.
- W4281752600 cites W2791155359 @default.
- W4281752600 cites W2791420379 @default.
- W4281752600 cites W2792238344 @default.
- W4281752600 cites W2793370606 @default.
- W4281752600 cites W2796269683 @default.
- W4281752600 cites W2804410820 @default.
- W4281752600 cites W2817838603 @default.
- W4281752600 cites W2895563925 @default.
- W4281752600 cites W2895619213 @default.
- W4281752600 cites W2906871145 @default.
- W4281752600 cites W2911253006 @default.
- W4281752600 cites W2912245252 @default.
- W4281752600 cites W2945067244 @default.
- W4281752600 cites W2948469692 @default.
- W4281752600 cites W2949177718 @default.
- W4281752600 cites W2966465234 @default.
- W4281752600 cites W2970127552 @default.
- W4281752600 cites W2982495007 @default.
- W4281752600 cites W2982642439 @default.
- W4281752600 cites W2984472267 @default.
- W4281752600 cites W2991331813 @default.
- W4281752600 cites W2996190907 @default.
- W4281752600 cites W2996238888 @default.
- W4281752600 cites W2997280954 @default.
- W4281752600 cites W2997834390 @default.
- W4281752600 cites W3002417351 @default.
- W4281752600 cites W3003058300 @default.
- W4281752600 cites W3004330030 @default.
- W4281752600 cites W3036206386 @default.
- W4281752600 cites W3036371598 @default.
- W4281752600 cites W3047141442 @default.
- W4281752600 cites W3081219157 @default.
- W4281752600 cites W3091793771 @default.
- W4281752600 cites W3092493138 @default.