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• W4281753998 abstract "Abstract Background Allergy to dogs affects around 10% of the population in developed countries. Immune therapy of allergic patients with dog allergen extracts has shown limited therapeutic benefit. Methods We established a mouse model of dog allergy by repeatedly administering dog dander and epithelium extracts via the intranasal route. We also assessed the efficacy of a recombinant multimeric protein containing Can f 1, f 2, f 4 and f 6 in preventing inflammatory responses to dog extracts. Results Repeated inhalation of dog extracts induced infiltration of the airways by T H 2 cells, eosinophils and goblet cells, reminiscent of the house dust mite (HDM) model of asthma. Dog extracts also induced robust airway hyperresponsiveness and promoted T H 17 cell responses, which was associated with a high neutrophilic infiltration of the airways. scRNA‐Seq analysis of T helper cells in the airways pinpointed a unique gene signature for T H 17 cells. Analysis of T‐cell receptors depicted a high frequency of clones that were shared between T H 17, T H 2 and suppressive Treg cells, indicative of a common differentiation trajectory for these subsets. Importantly, sublingual administration of multimeric Can f 1‐2‐4‐6 protein prior to sensitization reduced airway hyperresponsiveness and type 2‐mediated inflammation in this model. Conclusion Dog allergen extracts induce robust T H 2 and T H 17 cell‐mediated responses in mice. Recombinant Can f 1‐2‐4‐6 can induce tolerance to complex dog allergen extracts." @default.
• W4281753998 created "2022-06-13" @default.
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• W4281753998 date "2022-06-20" @default.
• W4281753998 modified "2023-10-18" @default.
• W4281753998 title "Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous <scp> T _H 2 </scp> and <scp> T _H 17 </scp> cell responses" @default.
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• W4281753998 doi "https://doi.org/10.1111/all.15399" @default.
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