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- W4281757475 abstract "Squamous cell carcinoma of larynx is one of the most common malignant neoplasms of the head and neck. Carcinoma of the larynx represents 2.2% of all cancers in men and 0.4% in women, with predilection of old aged men of more than 50 years rather than women. Smoking is the main risk factor. Alcohol, nutritional factors and virus as Human papillomavirus (HPV) play a role in the pathogenesis of laryngeal carcinoma. Programmed death-ligand (PDL1) is the new introduced marker that be considered as treatment target nowadays in addition to its prognostic application. Aims of study: This study was designed to assess the predictive the role of PDL1 in laryngeal squamous cell carcinoma in comparison with other prognostic markers (P53 and Ki-67).Results: The current study revealed that PDL1 expression was reported in about 20 % of laryngeal squamous cell carcinoma and 10% in premalignant, while it was negative in benign laryngeal lesions. Others markers; P53 protein was shown to be positive in around 42.5 percent of laryngeal squamous cell carcinomas, 40 percent of premalignant laryngeal lesions, and about 12 percent of benign laryngeal lesions." @default.
- W4281757475 created "2022-06-13" @default.
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- W4281757475 date "2022-06-07" @default.
- W4281757475 modified "2023-09-27" @default.
- W4281757475 title "Immunohistochemical expression of PDL1 in laryngeal carcinoma in relation to P53 and ki67 proliferative index" @default.
- W4281757475 doi "https://doi.org/10.53730/ijhs.v6ns2.8516" @default.
- W4281757475 hasPublicationYear "2022" @default.
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