Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281760128> ?p ?o ?g. }
- W4281760128 abstract "Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) structure called perineuronal net (PNN), which can regulate their synaptic input. In this study, we investigated the relationship between PNNs, parvalbumin interneurons, and synaptic distribution on these cells in the adult primary visual cortex (V1) of quadruple knockout mice deficient for the ECM molecules brevican, neurocan, tenascin-C, and tenascin-R. We used super-resolution structured illumination microscopy (SIM) to analyze PNN structure and associated synapses. In addition, we examined parvalbumin and calretinin interneuron populations. We observed a reduction in the number of PNN-enwrapped cells and clear disorganization of the PNN structure in the quadruple knockout V1. This was accompanied by an imbalance of inhibitory and excitatory synapses with a reduction of inhibitory and an increase of excitatory synaptic elements along the PNNs. Furthermore, the number of parvalbumin interneurons was reduced in the quadruple knockout, while calretinin interneurons, which do not wear PNNs, did not display differences in number. Interestingly, we found the transcription factor Otx2 homeoprotein positive cell population also reduced. Otx2 is crucial for parvalbumin interneuron and PNN maturation, and a positive feedback loop between these parameters has been described. Collectively, these data indicate an important role of brevican, neurocan, tenascin-C, and tenascin-R in regulating the interplay between PNNs, inhibitory interneurons, synaptic distribution, and Otx2 in the V1." @default.
- W4281760128 created "2022-06-13" @default.
- W4281760128 creator A5002237314 @default.
- W4281760128 creator A5003309051 @default.
- W4281760128 creator A5026189128 @default.
- W4281760128 creator A5064606841 @default.
- W4281760128 creator A5073070783 @default.
- W4281760128 creator A5086749242 @default.
- W4281760128 date "2022-06-02" @default.
- W4281760128 modified "2023-09-30" @default.
- W4281760128 title "Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2" @default.
- W4281760128 cites W1562783671 @default.
- W4281760128 cites W1572938127 @default.
- W4281760128 cites W1613369435 @default.
- W4281760128 cites W1690718176 @default.
- W4281760128 cites W1797102164 @default.
- W4281760128 cites W1806509508 @default.
- W4281760128 cites W1882017381 @default.
- W4281760128 cites W1883330555 @default.
- W4281760128 cites W1968455009 @default.
- W4281760128 cites W1970127647 @default.
- W4281760128 cites W1971613536 @default.
- W4281760128 cites W1974815300 @default.
- W4281760128 cites W1986126224 @default.
- W4281760128 cites W1988532274 @default.
- W4281760128 cites W1998880226 @default.
- W4281760128 cites W2003726233 @default.
- W4281760128 cites W2011562444 @default.
- W4281760128 cites W2012448906 @default.
- W4281760128 cites W2013529343 @default.
- W4281760128 cites W2021346586 @default.
- W4281760128 cites W2024403928 @default.
- W4281760128 cites W2027174813 @default.
- W4281760128 cites W2030718505 @default.
- W4281760128 cites W2032089725 @default.
- W4281760128 cites W2032464872 @default.
- W4281760128 cites W2033004840 @default.
- W4281760128 cites W2040502575 @default.
- W4281760128 cites W2045295282 @default.
- W4281760128 cites W2053630894 @default.
- W4281760128 cites W2061497228 @default.
- W4281760128 cites W2062106375 @default.
- W4281760128 cites W2064297038 @default.
- W4281760128 cites W2064699827 @default.
- W4281760128 cites W2065547544 @default.
- W4281760128 cites W2065637628 @default.
- W4281760128 cites W2066330985 @default.
- W4281760128 cites W2066523597 @default.
- W4281760128 cites W2072133859 @default.
- W4281760128 cites W2080980905 @default.
- W4281760128 cites W2085339091 @default.
- W4281760128 cites W2086582222 @default.
- W4281760128 cites W2089089729 @default.
- W4281760128 cites W2091187766 @default.
- W4281760128 cites W2092551589 @default.
- W4281760128 cites W2096385890 @default.
- W4281760128 cites W2096472685 @default.
- W4281760128 cites W2097469682 @default.
- W4281760128 cites W2099249565 @default.
- W4281760128 cites W2100171700 @default.
- W4281760128 cites W2100322061 @default.
- W4281760128 cites W2106489369 @default.
- W4281760128 cites W2115914792 @default.
- W4281760128 cites W2119792393 @default.
- W4281760128 cites W2124266106 @default.
- W4281760128 cites W2130512993 @default.
- W4281760128 cites W2131899586 @default.
- W4281760128 cites W2141532154 @default.
- W4281760128 cites W2146369085 @default.
- W4281760128 cites W2150947848 @default.
- W4281760128 cites W2158402600 @default.
- W4281760128 cites W2159022089 @default.
- W4281760128 cites W2160087707 @default.
- W4281760128 cites W2171439331 @default.
- W4281760128 cites W2181714077 @default.
- W4281760128 cites W2341645163 @default.
- W4281760128 cites W2402187732 @default.
- W4281760128 cites W2410908538 @default.
- W4281760128 cites W2420689037 @default.
- W4281760128 cites W2462889082 @default.
- W4281760128 cites W2552797979 @default.
- W4281760128 cites W2588700717 @default.
- W4281760128 cites W2616760772 @default.
- W4281760128 cites W2617330611 @default.
- W4281760128 cites W2618096481 @default.
- W4281760128 cites W2735735043 @default.
- W4281760128 cites W2771874017 @default.
- W4281760128 cites W2792435243 @default.
- W4281760128 cites W2793185007 @default.
- W4281760128 cites W2894865807 @default.
- W4281760128 cites W2904872461 @default.
- W4281760128 cites W2922660066 @default.
- W4281760128 cites W2945129130 @default.
- W4281760128 cites W2948487620 @default.
- W4281760128 cites W2950437522 @default.
- W4281760128 cites W2952526794 @default.
- W4281760128 cites W2955918581 @default.
- W4281760128 cites W2969588759 @default.
- W4281760128 cites W2971531104 @default.
- W4281760128 cites W2975653464 @default.