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- W4281762685 abstract "Microgel-mediated surface modification has shown great promises for a variety of metallic and non-metallic substrates. Yet, despite its compelling merits, this approach is less implemented on soft hydrogel substrates. Here, using the well-known bioinert agarose hydrogel as an example, we highlight a microgels-on-macrogel strategy that readily confers cytophilicity to the agarose surface toward anchorage-dependent cells. Specifically, we selected glycerol diglycidyl ether to tailor design polyetheramine-bisepoxide-based cationic microgels with more prominent ether alcohol features for enhanced chemical compatibility with agarose. Through a simple drop casting method, concurrent modifications of chemical, morphological and mechanical properties of the surface of agarose gel were then achieved with these microgels bound to the surface in a non-covalent yet robust manner. With the mere introduction of the cationic microgels, not only was the non-adhesive agarose surface effectively transformed to be cytophilic shown by the favorable responses from the in vitro culture of MC3T3-E1 cells, but also was hydrophobic reservoir function integrated conveniently. The demonstration of its feasibility and versatility warrants continued research of this straightforward microgels-on-macrogel strategy, which could be of value particularly for the development of novel biointerfaces." @default.
- W4281762685 created "2022-06-13" @default.
- W4281762685 creator A5026768917 @default.
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- W4281762685 date "2022-10-01" @default.
- W4281762685 modified "2023-10-17" @default.
- W4281762685 title "Microgels-on-macrogel: A simple cytophilic surface makeover of soft agarose substrates" @default.
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- W4281762685 doi "https://doi.org/10.1016/j.jciso.2022.100056" @default.
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